Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats.

Kim MY, Kim EJ, Kim YN, Choi C, Lee BH

Nutrition research and practice28 Oct 2011Cited by 57 (Europe PMC)

PMID22125679PMCIDPMC3221827DOI10.4162/nrp.2011.5.5.421PepBankPUB-22125679

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study19

14 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine increased skin SOD activity compared with control diet.
In plain wordsIn rats, L‑carnosine increased skin SOD activity compared with control diet.
Peptide
L-carnosine
Outcome
IncreaseSkin SOD activity
Study
ratn: not reported in source
Dietary supplementation
Comparator
Control diet
Outcome group
Inflammation markers · Skin and wound
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Skin and liver SOD activities of the ALA and LC groups were higher than those of the CON group (P < 0.05), but serum SOD activity was higher only in the LC group compared to that in the CON group (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine increased liver SOD activity compared with control diet.
In plain wordsIn rats, L‑carnosine increased liver SOD activity compared with control diet.
Peptide
L-carnosine
Outcome
IncreaseLiver SOD activity
Study
ratn: not reported in source
Dietary supplementation
Comparator
Control diet
Outcome group
Inflammation markers · Liver
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Skin and liver SOD activities of the ALA and LC groups were higher than those of the CON group (P < 0.05), but serum SOD activity was higher only in the LC group compared to that in the CON group (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine increased serum SOD activity compared with control diet.
In plain wordsIn rats, L‑carnosine increased serum SOD activity compared with control diet.
Peptide
L-carnosine
Outcome
IncreaseSerum SOD activity
Study
ratn: not reported in source
Dietary supplementation
Comparator
Control diet
Outcome group
Inflammation markers · Whole body
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Skin and liver SOD activities of the ALA and LC groups were higher than those of the CON group (P < 0.05), but serum SOD activity was higher only in the LC group compared to that in the CON group (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine increased liver GSH-Px activity compared with control diet.
In plain wordsIn rats, L‑carnosine increased liver GSH-Px activity compared with control diet.
Peptide
L-carnosine
Outcome
IncreaseLiver GSH-Px activity
Study
ratn: not reported in source
Dietary supplementation
Comparator
Control diet
Outcome group
Inflammation markers · Liver
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Additionally, only liver GSH-Px activity in the LC group was higher than that of the CON and the other groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567904
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine increased liver GSH-Px activity compared with ALA diet.
In plain wordsIn rats, L‑carnosine increased liver GSH-Px activity compared with ALA diet.
Peptide
L-carnosine
Outcome
IncreaseLiver GSH-Px activity
Study
ratn: not reported in source
Dietary supplementation
Comparator
ALA diet
Outcome group
Inflammation markers · Liver
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Additionally, only liver GSH-Px activity in the LC group was higher than that of the CON and the other groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567905
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine increased liver GSH-Px activity compared with ALA plus LC diet.
In plain wordsIn rats, L‑carnosine increased liver GSH-Px activity compared with ALA plus LC diet.
Peptide
L-carnosine
Outcome
IncreaseLiver GSH-Px activity
Study
ratn: not reported in source
Dietary supplementation
Comparator
ALA plus LC diet
Outcome group
Inflammation markers · Liver
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Additionally, only liver GSH-Px activity in the LC group was higher than that of the CON and the other groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567906
07AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine reduced serum MDA compared with control diet.
In plain wordsIn rats, L‑carnosine reduced serum MDA compared with control diet.
Peptide
L-carnosine
Outcome
DecreaseSerum MDA
Study
ratn: not reported in source
Dietary supplementation
Comparator
Control diet
Outcome group
Inflammation markers · Whole body
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Serum and skin MDA levels in the ALA and LC groups were lower than those in the CON group (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567907
08AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine reduced skin MDA compared with control diet.
In plain wordsIn rats, L‑carnosine reduced skin MDA compared with control diet.
Peptide
L-carnosine
Outcome
DecreaseSkin MDA
Study
ratn: not reported in source
Dietary supplementation
Comparator
Control diet
Outcome group
Inflammation markers · Skin and wound
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Serum and skin MDA levels in the ALA and LC groups were lower than those in the CON group (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567908
09AnimalAnimal study (in vivo)Efficacy outcome
In rats, serum triglycerides were higher with L‑carnosine than with ALA.
In plain wordsIn rats, serum triglycerides were higher with L‑carnosine than with ALA.
Peptide
L-carnosine
Outcome
IncreaseSerum triglycerides
Study
ratn: not reported in source
Dietary supplementation
Comparator
ALA diet
Outcome group
Lipids · Metabolic and weight
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Serum TG and TC in the ALA and ALA + LC groups were lower than those in the CON and LC groups (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567909
10AnimalAnimal study (in vivo)Efficacy outcome
In rats, serum total cholesterol was higher with L‑carnosine than with ALA.
In plain wordsIn rats, serum total cholesterol was higher with L‑carnosine than with ALA.
Peptide
L-carnosine
Outcome
IncreaseSerum total cholesterol
Study
ratn: not reported in source
Dietary supplementation
Comparator
ALA diet
Outcome group
Lipids · Metabolic and weight
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
Serum TG and TC in the ALA and ALA + LC groups were lower than those in the CON and LC groups (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567910
11AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine increased HDL-C compared with control diet.
In plain wordsIn rats, L‑carnosine increased HDL cholesterol compared with control diet.
Peptide
L-carnosine
Outcome
IncreaseHDL cholesterol
Study
ratn: not reported in source
Dietary supplementation
Comparator
Control diet
Outcome group
Lipids · Metabolic and weight
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
The HDL-C level in the LC group was higher than that in any other group (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567915
12AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine increased HDL-C compared with ALA diet.
In plain wordsIn rats, L‑carnosine increased HDL cholesterol compared with ALA diet.
Peptide
L-carnosine
Outcome
IncreaseHDL cholesterol
Study
ratn: not reported in source
Dietary supplementation
Comparator
ALA diet
Outcome group
Lipids · Metabolic and weight
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
The HDL-C level in the LC group was higher than that in any other group (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567916
13AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine increased HDL-C compared with ALA plus LC diet.
In plain wordsIn rats, L‑carnosine increased HDL cholesterol compared with ALA plus LC diet.
Peptide
L-carnosine
Outcome
IncreaseHDL cholesterol
Study
ratn: not reported in source
Dietary supplementation
Comparator
ALA plus LC diet
Outcome group
Lipids · Metabolic and weight
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
The HDL-C level in the LC group was higher than that in any other group (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567917
14AnimalAnimal study (in vivo)Efficacy outcome
In rats, L‑carnosine reduced LDL-C compared with control diet.
In plain wordsIn rats, L‑carnosine reduced LDL cholesterol compared with control diet.
Peptide
L-carnosine
Outcome
DecreaseLDL cholesterol
Study
ratn: not reported in source
Dietary supplementation
Comparator
Control diet
Outcome group
Lipids · Metabolic and weight
Studied dose
0.5% L-carnosine in diet · oral · 6 weeksAs given in this study (rat).
Source sentences
Summary
LDL-C level was lower in the ALA + LC and LC groups than that in the CON group (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
Report a problemFND-2212567918

Studies that did not test the peptide alone5

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

15AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In rats, ALA plus L‑carnosine reduced serum triglycerides compared with control diet.
In plain wordsIn rats, ALA plus L‑carnosine reduced serum triglycerides compared with control diet.
Peptide
L-carnosine
Outcome
DecreaseSerum triglycerides
Study
ratn: not reported in source
Dietary supplementation
Comparator
Control diet
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
Serum TG and TC in the ALA and ALA + LC groups were lower than those in the CON and LC groups (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2212567911
16AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In rats, ALA plus L‑carnosine reduced serum total cholesterol compared with control diet.
In plain wordsIn rats, ALA plus L‑carnosine reduced serum total cholesterol compared with control diet.
Peptide
L-carnosine
Outcome
DecreaseSerum total cholesterol
Study
ratn: not reported in source
Dietary supplementation
Comparator
Control diet
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
Serum TG and TC in the ALA and ALA + LC groups were lower than those in the CON and LC groups (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2212567912
17AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In rats, ALA plus L‑carnosine reduced serum triglycerides compared with L‑carnosine alone.
In plain wordsIn rats, ALA plus L‑carnosine reduced serum triglycerides compared with L‑carnosine alone.
Peptide
L-carnosine
Outcome
DecreaseSerum triglycerides
Study
ratn: not reported in source
Dietary supplementation
Comparator
LC diet
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
Serum TG and TC in the ALA and ALA + LC groups were lower than those in the CON and LC groups (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2212567913
18AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In rats, ALA plus L‑carnosine reduced serum total cholesterol compared with L‑carnosine alone.
In plain wordsIn rats, ALA plus L‑carnosine reduced serum total cholesterol compared with L‑carnosine alone.
Peptide
L-carnosine
Outcome
DecreaseSerum total cholesterol
Study
ratn: not reported in source
Dietary supplementation
Comparator
LC diet
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
Serum TG and TC in the ALA and ALA + LC groups were lower than those in the CON and LC groups (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2212567914
19AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In rats, ALA plus L‑carnosine reduced LDL-C compared with control diet.
In plain wordsIn rats, ALA plus L‑carnosine reduced LDL cholesterol compared with control diet.
Peptide
L-carnosine
Outcome
DecreaseLDL cholesterol
Study
ratn: not reported in source
Dietary supplementation
Comparator
Control diet
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
LDL-C level was lower in the ALA + LC and LC groups than that in the CON group (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks.
Summary · context
Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC).
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2212567919

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Keywords

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