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Study · Not a test of the peptide alone · 2012

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A novel small Odorranalectin-bearing cubosomes: preparation, brain delivery and pharmacodynamic study on amyloid-β₂₅₋₃₅-treated rats following intranasal administration.

Wu H, Li J, Zhang Q, Yan X, Guo L, Gao X, Qiu M, Jiang X, Lai R, Chen H

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V28 Oct 2011Cited by 60 (Europe PMC)

PMID22061263 (opens in a new tab)DOI10.1016/j.ejpb.2011.10.012 (opens in a new tab)PepBankPUB-22061263
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In rats with an amyloid-induced Alzheimer's disease model, odorranalectin functionalization enhanced the therapeutic effects of S14G-HN-loaded cubosomes.

    In plain wordsIn rats, adding a targeting peptide to carrier particles made a humanin derivative work better in an Alzheimer's model.

    Peptide
    Humanin
    Outcome
    IncreaseTherapeutic effect of S14G-HN-loaded cubosomes with odorranalectin
    Study

    ratn: not reported in source

    Rats with amyloid-β25-35-induced Alzheimer's disease model, intranasal
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    The results suggested that OL functionalization enhanced the therapeutic effects of S14G-HN-loaded cubosomes on AD.
    1 context sentence
    Summary · context
    Besides, Gly14-Humanin (S14G-HN) as a model peptide drug was loaded into cubosomes and evaluated for its pharmacodynamics on Alzheimer's disease (AD) rats following intranasal administration by Morris water maze test and acetylcholinesterase activity determination.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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