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Study · Not a test of the peptide alone · 2012

3 results

Self-assembled polymersomes conjugated with lactoferrin as novel drug carrier for brain delivery.

Yu Y, Pang Z, Lu W, Yin Q, Gao H, Jiang X

Pharmaceutical research7 Oct 2011Cited by 53 (Europe PMC)

PMID21979908 (opens in a new tab)DOI10.1007/s11095-011-0513-7 (opens in a new tab)PepBankPUB-21979908
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In rats treated with amyloid-β(25-35), S14G-humanin in lactoferrin polymersomes attenuated the expression of Bax-positive cells.

    In plain wordsIn rats, a humanin derivative in a brain-targeting carrier lowered the number of cells that show a cell-death marker.

    Peptide
    Humanin
    Outcome
    DecreaseBax-positive cells in hippocampus
    Study

    ratn: not reported in source

    Rats treated with amyloid-β(25-35), hippocampus
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Immunohistochemistry revealed the SHN-Lf-POS had a protective effect on neurons of rats by attenuating the expression of Bax and caspase-3 positive cells.
    1 context sentence
    Summary · context
    A neuroprotective peptide, S14G-humanin, was incorporated into Lf-POS (SHN-Lf-POS); a protective effect on the hippocampuses of rats treated by Amyloid-β(25-35) was investigated by immunohistochemical analysis.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In rats treated with amyloid-β(25-35), S14G-humanin in lactoferrin polymersomes attenuated the expression of caspase-3-positive cells.

    In plain wordsIn rats, a humanin derivative in a brain-targeting carrier lowered the number of cells that show a cell-death enzyme.

    Peptide
    Humanin
    Outcome
    DecreaseCaspase-3-positive cells in hippocampus
    Study

    ratn: not reported in source

    Rats treated with amyloid-β(25-35), hippocampus
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Immunohistochemistry revealed the SHN-Lf-POS had a protective effect on neurons of rats by attenuating the expression of Bax and caspase-3 positive cells.
    1 context sentence
    Summary · context
    A neuroprotective peptide, S14G-humanin, was incorporated into Lf-POS (SHN-Lf-POS); a protective effect on the hippocampuses of rats treated by Amyloid-β(25-35) was investigated by immunohistochemical analysis.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In rats treated with amyloid-β(25-35), choline acetyltransferase activity was higher with S14G-humanin in lactoferrin polymersomes than in negative controls.

    In plain wordsIn rats, a humanin derivative in a brain-targeting carrier raised the activity of a nerve enzyme compared with negative controls.

    Peptide
    Humanin
    Outcome
    IncreaseCholine acetyltransferase activity
    Study

    ratn: not reported in source

    Rats treated with amyloid-β(25-35), hippocampus
    Comparator
    Negative controls
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Meanwhile, the activity of choline acetyltransferase (ChAT) had been increased compared with negative controls.
    1 context sentence
    Summary · context
    A neuroprotective peptide, S14G-humanin, was incorporated into Lf-POS (SHN-Lf-POS); a protective effect on the hippocampuses of rats treated by Amyloid-β(25-35) was investigated by immunohistochemical analysis.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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