[Thymus and adaptive changes of bone marrow cell composition in animals of different age].

Labunets IF, Rodnichenko AE, Magdich LV, Butenko GM

Advances in gerontology = Uspekhi gerontologii1 Jan 2011

PMID21957575PepBankPUB-21957575

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In old mice, thymalin administration increased FTS levels.
In plain wordsIn mice, thymalin increased FTS levels in old animals.
Peptide
Thymalin
Outcome
IncreaseFTS level
Study
CBA micen: not reported in source
Old mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
FTS level in old mice increased after administration of thymalin, the rhythm of CD(4+)-cells number in bone marrow and of corticosterone serum content restored.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of thymus removal or administration of thymalin, thymic peptide factor, on number of cells-precursors for colonies of fibroblasts (CFC-F) and for granulocyte-macrophageal colonies (CFC-GM), CD(4+)-cells in bone marrow in CBA mice of different age in some seasons was investigated.
Report a problemFND-2195757501
02AnimalAnimal study (in vivo)Mechanism
In old mice, thymalin restored the rhythm of bone marrow CD(4+) cell numbers.
In plain wordsIn mice, thymalin restored the rhythm of immune cell numbers in bone marrow of old animals.
Peptide
Thymalin
Outcome
Not applicableBone marrow CD(4+) cell rhythm
Study
CBA micen: not reported in source
Old mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
FTS level in old mice increased after administration of thymalin, the rhythm of CD(4+)-cells number in bone marrow and of corticosterone serum content restored.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of thymus removal or administration of thymalin, thymic peptide factor, on number of cells-precursors for colonies of fibroblasts (CFC-F) and for granulocyte-macrophageal colonies (CFC-GM), CD(4+)-cells in bone marrow in CBA mice of different age in some seasons was investigated.
Report a problemFND-2195757502
03AnimalAnimal study (in vivo)Mechanism
In old mice, thymalin restored the rhythm of serum corticosterone content.
In plain wordsIn mice, thymalin restored the rhythm of blood corticosterone levels in old animals.
Peptide
Thymalin
Outcome
Not applicableSerum corticosterone rhythm
Study
CBA micen: not reported in source
Old mice
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
FTS level in old mice increased after administration of thymalin, the rhythm of CD(4+)-cells number in bone marrow and of corticosterone serum content restored.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of thymus removal or administration of thymalin, thymic peptide factor, on number of cells-precursors for colonies of fibroblasts (CFC-F) and for granulocyte-macrophageal colonies (CFC-GM), CD(4+)-cells in bone marrow in CBA mice of different age in some seasons was investigated.
Report a problemFND-2195757503

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

04AnimalEndogenous levelAnimal study (in vivo)Other
In old mice, thymalin administration increased endogenous FTS levels.
In plain wordsIn old mice, thymalin increased natural thymulin levels.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseFTS level after thymalin
Study
mousen: not reported in source
CBA mouse bone marrow
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
FTS level in old mice increased after administration of thymalin,
This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2195757506

Studies that did not test the peptide alone2

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

05AnimalNot a test of Thymalin aloneAnimal study (in vivo)Mechanism
In adult mice, the direction of bone marrow cell responses to thymic activity modulation depended on season.
In plain wordsIn mice, bone marrow cell responses to thymic activity changes depended on season.
Peptide
Thymalin
Outcome
MixedSeasonal bone marrow cell response
Study
CBA micen: not reported in source
Adult mice across seasons
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
It was shown that in adult mice the orientation of influence thymic activity modulation on amount of these types cells is dependent from seasons.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of thymus removal or administration of thymalin, thymic peptide factor, on number of cells-precursors for colonies of fibroblasts (CFC-F) and for granulocyte-macrophageal colonies (CFC-GM), CD(4+)-cells in bone marrow in CBA mice of different age in some seasons was investigated.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-2195757504
06LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueActivity measurement
In old mouse bone marrow cultures, thymic supernatant increased CD4-positive cell abundance.
In plain wordsIn lab tests, thymic supernatant increased CD4-positive cells in old mouse bone marrow.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseCD4-positive cell abundance
Study
mousen: not reported in source
CBA mouse bone marrow
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
in old mice thymic supernatant increased in vitro the amount of CD(4+)-cells.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-2195757505

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 12:50 UTC
Study data updated · source update from Europe PMC
Version 2
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC