Novel mitochondria-targeted antioxidant peptide ameliorates burn-induced apoptosis and endoplasmic reticulum stress in the skeletal muscle of mice.

Lee HY, Kaneki M, Andreas J, Tompkins RG, Martyn JA

Shock (Augusta, Ga.)1 Dec 2011Cited by 37 (Europe PMC)

PMID21937949PMCIDPMC3230221DOI10.1097/shk.0b013e3182366872PepBankPUB-21937949

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In burned mice, SS‑31 peptide prevented the burn-induced increase in caspase 3 activity in skeletal muscle on postburn day 7.
In plain wordsIn mice with burns, SS‑31 prevented the rise in a cell-death enzyme in muscle.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseCaspase 3 activity (postburn day 7)
Study
mousen: not reported in source
Mice with 30% total body surface area burn
Comparator
Burned mice without SS-31
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
5 mg/kg body weight dailyAs given in this study (mouse).
Source sentences
Summary
Treatment with SS-31 peptide prevented burn-induced increases in the caspase 3 activity (P < 0.05)
1 context sentence(design, population, supporting numbers)
Summary · context
Following 30% total body surface area burn or sham burn, mice were injected daily with SS-31 peptide (5 mg/kg body weight), and the rectus abdominis muscles collected on postburn days 1, 3, and 7.
Report a problemFND-2193794901
02AnimalAnimal study (in vivo)Mechanism
In burned mice, SS‑31 peptide prevented the burn-induced increase in apoptosis in skeletal muscle on postburn day 7.
In plain wordsIn mice with burns, SS‑31 prevented the rise in programmed cell death in muscle.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseMuscle apoptosis (postburn day 7)
Study
mousen: not reported in source
Mice with 30% total body surface area burn
Comparator
Burned mice without SS-31
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
5 mg/kg body weight dailyAs given in this study (mouse).
Source sentences
Summary
Treatment with SS-31 peptide prevented burn-induced increases in the caspase 3 activity (P < 0.05) and apoptosis (P < 0.01) on postburn day 7
1 context sentence(design, population, supporting numbers)
Summary · context
Following 30% total body surface area burn or sham burn, mice were injected daily with SS-31 peptide (5 mg/kg body weight), and the rectus abdominis muscles collected on postburn days 1, 3, and 7.
Report a problemFND-2193794902
03AnimalAnimal study (in vivo)Mechanism
In burned mice, SS‑31 peptide prevented the burn-induced increase in phosphatase and tensin homolog expression on postburn days 3 and 7.
In plain wordsIn mice with burns, SS‑31 prevented the rise in a signalling protein (PTEN) in muscle.
Peptide
Elamipretide (SS-31)
Outcome
DecreasePTEN expression (postburn days 3 and 7)
Study
mousen: not reported in source
Mice with 30% total body surface area burn
Comparator
Burned mice without SS-31
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
5 mg/kg body weight dailyAs given in this study (mouse).
Source sentences
Summary
The SS-31 peptide treatment also prevented the increase in the expression levels of phosphatase and tensin homolog on postburn days 3 and 7.
1 context sentence(design, population, supporting numbers)
Summary · context
Following 30% total body surface area burn or sham burn, mice were injected daily with SS-31 peptide (5 mg/kg body weight), and the rectus abdominis muscles collected on postburn days 1, 3, and 7.
Report a problemFND-2193794903
04AnimalAnimal study (in vivo)Mechanism
In burned mice, SS‑31 peptide significantly decreased the burn-induced increase in the endoplasmic reticulum stress marker binding immunoglobulin protein on postburn days 3 and 7.
In plain wordsIn mice with burns, SS‑31 lowered a stress marker in muscle cells.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseBinding immunoglobulin protein (ER stress marker)
Study
mousen: not reported in source
Mice with 30% total body surface area burn
Comparator
Burned mice without SS-31
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
5 mg/kg body weight dailyAs given in this study (mouse).
Source sentences
Summary
Burn injury-induced increases in the levels of two endoplasmic reticulum stress markers, binding immunoglobulin protein and protein disulfide isomerase, were significantly decreased by the SS-31 peptide treatments on postburn day 7 and on day 3 for binding immunoglobulin protein as well (P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Following 30% total body surface area burn or sham burn, mice were injected daily with SS-31 peptide (5 mg/kg body weight), and the rectus abdominis muscles collected on postburn days 1, 3, and 7.
Report a problemFND-2193794904
05AnimalAnimal study (in vivo)Mechanism
In burned mice, SS‑31 peptide significantly decreased the burn-induced increase in the endoplasmic reticulum stress marker protein disulfide isomerase on postburn day 7.
In plain wordsIn mice with burns, SS‑31 lowered a second stress marker in muscle cells.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseProtein disulfide isomerase (ER stress marker)
Study
mousen: not reported in source
Mice with 30% total body surface area burn
Comparator
Burned mice without SS-31
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
5 mg/kg body weight dailyAs given in this study (mouse).
Source sentences
Summary
Burn injury-induced increases in the levels of two endoplasmic reticulum stress markers, binding immunoglobulin protein and protein disulfide isomerase, were significantly decreased by the SS-31 peptide treatments on postburn day 7 and on day 3 for binding immunoglobulin protein as well (P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Following 30% total body surface area burn or sham burn, mice were injected daily with SS-31 peptide (5 mg/kg body weight), and the rectus abdominis muscles collected on postburn days 1, 3, and 7.
Report a problemFND-2193794905
06AnimalAnimal study (in vivo)Mechanism
In burned mice, SS‑31 peptide reduced the expression of oxidized proteins in muscle on postburn day 7.
In plain wordsIn mice with burns, SS‑31 reduced oxidized proteins in muscle.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseOxidized protein expression (postburn day 7)
Study
mousen: not reported in source
Mice with 30% total body surface area burn
Comparator
Burned mice without SS-31
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
5 mg/kg body weight dailyAs given in this study (mouse).
Source sentences
Summary
The effects of SS-31 appear to be, in part, due to its ability to reduce oxidative stress in burned mice, evidenced by reduced expression of oxidized proteins that were clearly evident on postburn day 7.
1 context sentence(design, population, supporting numbers)
Summary · context
Following 30% total body surface area burn or sham burn, mice were injected daily with SS-31 peptide (5 mg/kg body weight), and the rectus abdominis muscles collected on postburn days 1, 3, and 7.
Report a problemFND-2193794906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.