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Study · In vitro (cells) · 2011

9 results

Thymosin β4 activates integrin-linked kinase and decreases endothelial progenitor cells apoptosis under serum deprivation.

Zhao Y, Qiu F, Xu S, Yu L, Fu G

Journal of cellular physiology1 Nov 2011Cited by 33 (Europe PMC)

PMID21935929 (opens in a new tab)DOI10.1002/jcp.22624 (opens in a new tab)PepBankPUB-21935929
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human endothelial progenitor cells, Tβ4 caused a concentration-dependent increase in cell viability.

    In plain wordsIn cells, thymosin beta‑4 increased the viability of endothelial progenitor cells in a dose-dependent way.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEPC viability
    Study

    humann: not reported in source

    circulating endothelial progenitor cells under serum deprivation
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Incubation of EPCs with Tβ4 caused a concentration dependent increase in cell viability and proliferation activity.
    1 context sentence
    Summary · context
    Circulating EPCs, isolated from healthy volunteers, were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  2. 02LabIn vitro (cells)Activity measurement

    In human endothelial progenitor cells, Tβ4 caused a concentration-dependent increase in proliferation activity.

    In plain wordsIn cells, thymosin beta‑4 increased the growth of endothelial progenitor cells in a dose-dependent way.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEPC proliferation
    Study

    humann: not reported in source

    circulating endothelial progenitor cells under serum deprivation
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Incubation of EPCs with Tβ4 caused a concentration dependent increase in cell viability and proliferation activity.
    1 context sentence
    Summary · context
    Circulating EPCs, isolated from healthy volunteers, were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  3. 03LabIn vitro (cells)Activity measurement

    In human endothelial progenitor cells under serum deprivation, Tβ4 inhibited apoptosis.

    In plain wordsIn cells, thymosin beta‑4 reduced cell death of endothelial progenitor cells grown without serum.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseEPC apoptosis under serum deprivation
    Study

    humann: not reported in source

    circulating endothelial progenitor cells under serum deprivation
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It also caused an inhibitory effect on EPCs apoptosis, which was abolished by PI3K inhibitors (either LY294002 or Wortmannin) or JNK MAPK inhibitor SP600125.
    1 context sentence
    Summary · context
    Circulating EPCs, isolated from healthy volunteers, were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  4. 04LabIn vitro (cells)Mechanism

    The inhibitory effect of Tβ4 on EPC apoptosis was abolished by PI3K inhibitors (LY294002 or Wortmannin) or the JNK MAPK inhibitor SP600125.

    In plain wordsIn cells, blocking PI3K or JNK MAPK removed the protective effect of thymosin beta‑4 on cell death.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableEffect of PI3K and JNK MAPK inhibitors on the anti-apoptotic effect
    Study

    humann: not reported in source

    circulating endothelial progenitor cells under serum deprivation
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    which was abolished by PI3K inhibitors (either LY294002 or Wortmannin) or JNK MAPK inhibitor SP600125.
    1 context sentence
    Summary · context
    Circulating EPCs, isolated from healthy volunteers, were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  5. 05LabIn vitro (cells)Activity measurement

    In human endothelial progenitor cells, Tβ4 decreased the expression and activity of caspase-3 and caspase-9.

    In plain wordsIn cells, thymosin beta‑4 lowered the levels and activity of caspase-3 and caspase-9, enzymes of cell death.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCaspase-3 and caspase-9 expression and activity
    Study

    humann: not reported in source

    circulating endothelial progenitor cells under serum deprivation
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, the expression and activity of caspase-3 and -9 were decreased by Tβ4
    1 context sentence
    Summary · context
    Circulating EPCs, isolated from healthy volunteers, were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  6. 06LabIn vitro (cells)Mechanism

    In human endothelial progenitor cells, Tβ4 markedly increased the Bcl-2/Bax ratio.

    In plain wordsIn cells, thymosin beta‑4 markedly raised the Bcl-2/Bax ratio.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseBcl-2/Bax ratio
    Study

    humann: not reported in source

    circulating endothelial progenitor cells under serum deprivation
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    which markedly increased the Bcl-2/Bax ratio within EPCs.
    1 context sentence
    Summary · context
    Circulating EPCs, isolated from healthy volunteers, were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  7. 07LabIn vitro (cells)Mechanism

    In human endothelial progenitor cells, Tβ4 was immunoprecipitated with integrin-linked kinase (ILK).

    In plain wordsIn cells, thymosin beta‑4 was found bound to integrin-linked kinase.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableBinding of Tβ4 to integrin-linked kinase
    Study

    humann: not reported in source

    circulating endothelial progenitor cells under serum deprivation
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, Tβ4 was immunoprecipitated with integrin-linked kinase (ILK)
    1 context sentence
    Summary · context
    Circulating EPCs, isolated from healthy volunteers, were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  8. 08LabIn vitro (cells)Mechanism

    In human endothelial progenitor cells, Tβ4 augmented the activity of integrin-linked kinase.

    In plain wordsIn cells, thymosin beta‑4 increased the activity of integrin-linked kinase.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseILK activity
    Study

    humann: not reported in source

    circulating endothelial progenitor cells under serum deprivation
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    accompanied by augmentation of ILK activity.
    1 context sentence
    Summary · context
    Circulating EPCs, isolated from healthy volunteers, were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  9. 09LabIn vitro (cells)Mechanism

    ILK-siRNA transfection abolished the Tβ4-induced activation of ILK-Akt and the ameliorative effect of Tβ4 on apoptosis.

    In plain wordsIn cells, silencing integrin-linked kinase removed the effects of thymosin beta‑4 on Akt activation and cell death.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableEffect of ILK-siRNA on ILK-Akt activation and anti-apoptotic effect
    Study

    humann: not reported in source

    circulating endothelial progenitor cells under serum deprivation
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Transfection of EPCs with ILK-siRNA resulted in abolishment of the activation of ILK-Akt and the ameliorative effect on apoptosis by Tβ4.
    1 context sentence
    Summary · context
    Circulating EPCs, isolated from healthy volunteers, were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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