Humanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase.

Zhao ST, Huang XT, Zhang C, Ke Y

Neurochemical research21 Sept 2011Cited by 42 (Europe PMC)

PMID21935731DOI10.1007/s11064-011-0593-0PepBankPUB-21935731

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In cortical neurons exposed to ischemia and reperfusion, humanin pretreatment decreased lactate dehydrogenase release.
In plain wordsIn lab tests on neurons, humanin pretreatment lowered a marker of cell damage after oxygen loss and return.
Peptide
Humanin
Outcome
DecreaseLDH release after ischemia/reperfusion
Study
n: not reported in source
Cortical neurons, ischemia and reperfusion
Comparator
Ischemia/reperfusion without humanin
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of the cells with HN led to a significant decrease in LDH release, MDA formation and the number of karyopyknotic nuclei, and an increase in the number of Calcein-AM-positive living cells and cell viability in neurons treated with I/R.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we found that 4 h ischemia and 24 h reperfusion induced a significant increase in lactate dehydrogenase (LDH) release, malondialdehyde (MDA) formation and the number of karyopyknotic nuclei (4',6-diamidino-2-phenylindole dihydrochloride nuclear dyeing) and a decrease in the num…
Report a problemFND-2193573101
02LabIn vitro (cells)Efficacy outcome
In cortical neurons exposed to ischemia and reperfusion, humanin pretreatment decreased malondialdehyde formation.
In plain wordsIn lab tests on neurons, humanin pretreatment lowered a marker of oxidative damage after oxygen loss and return.
Peptide
Humanin
Outcome
DecreaseMDA formation after ischemia/reperfusion
Study
n: not reported in source
Cortical neurons, ischemia and reperfusion
Comparator
Ischemia/reperfusion without humanin
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of the cells with HN led to a significant decrease in LDH release, MDA formation and the number of karyopyknotic nuclei, and an increase in the number of Calcein-AM-positive living cells and cell viability in neurons treated with I/R.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we found that 4 h ischemia and 24 h reperfusion induced a significant increase in lactate dehydrogenase (LDH) release, malondialdehyde (MDA) formation and the number of karyopyknotic nuclei (4',6-diamidino-2-phenylindole dihydrochloride nuclear dyeing) and a decrease in the num…
Report a problemFND-2193573102
03LabIn vitro (cells)Efficacy outcome
In cortical neurons exposed to ischemia and reperfusion, humanin pretreatment decreased the number of karyopyknotic nuclei.
In plain wordsIn lab tests on neurons, humanin pretreatment reduced the number of shrunken, damaged nuclei after oxygen loss and return.
Peptide
Humanin
Outcome
DecreaseKaryopyknotic nuclei after ischemia/reperfusion
Study
n: not reported in source
Cortical neurons, ischemia and reperfusion
Comparator
Ischemia/reperfusion without humanin
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of the cells with HN led to a significant decrease in LDH release, MDA formation and the number of karyopyknotic nuclei, and an increase in the number of Calcein-AM-positive living cells and cell viability in neurons treated with I/R.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we found that 4 h ischemia and 24 h reperfusion induced a significant increase in lactate dehydrogenase (LDH) release, malondialdehyde (MDA) formation and the number of karyopyknotic nuclei (4',6-diamidino-2-phenylindole dihydrochloride nuclear dyeing) and a decrease in the num…
Report a problemFND-2193573103
04LabIn vitro (cells)Efficacy outcome
In cortical neurons exposed to ischemia and reperfusion, humanin pretreatment increased the number of Calcein-AM-positive living cells.
In plain wordsIn lab tests on neurons, humanin pretreatment kept more living cells after oxygen loss and return.
Peptide
Humanin
Outcome
IncreaseCalcein-AM-positive living cells after ischemia/reperfusion
Study
n: not reported in source
Cortical neurons, ischemia and reperfusion
Comparator
Ischemia/reperfusion without humanin
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of the cells with HN led to a significant decrease in LDH release, MDA formation and the number of karyopyknotic nuclei, and an increase in the number of Calcein-AM-positive living cells and cell viability in neurons treated with I/R.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we found that 4 h ischemia and 24 h reperfusion induced a significant increase in lactate dehydrogenase (LDH) release, malondialdehyde (MDA) formation and the number of karyopyknotic nuclei (4',6-diamidino-2-phenylindole dihydrochloride nuclear dyeing) and a decrease in the num…
Report a problemFND-2193573104
05LabIn vitro (cells)Efficacy outcome
In cortical neurons exposed to ischemia and reperfusion, humanin pretreatment increased cell viability.
In plain wordsIn lab tests on neurons, humanin pretreatment improved cell survival after oxygen loss and return.
Peptide
Humanin
Outcome
IncreaseCell viability after ischemia/reperfusion
Study
n: not reported in source
Cortical neurons, ischemia and reperfusion
Comparator
Ischemia/reperfusion without humanin
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of the cells with HN led to a significant decrease in LDH release, MDA formation and the number of karyopyknotic nuclei, and an increase in the number of Calcein-AM-positive living cells and cell viability in neurons treated with I/R.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we found that 4 h ischemia and 24 h reperfusion induced a significant increase in lactate dehydrogenase (LDH) release, malondialdehyde (MDA) formation and the number of karyopyknotic nuclei (4',6-diamidino-2-phenylindole dihydrochloride nuclear dyeing) and a decrease in the num…
Report a problemFND-2193573105
06LabIn vitro (cells)Mechanism
In cortical neurons exposed to ischemia and reperfusion, humanin pretreatment increased superoxide dismutase activity compared with ischemia and reperfusion alone.
In plain wordsIn lab tests on neurons, humanin pretreatment raised the activity of an antioxidant enzyme compared with oxygen loss alone.
Peptide
Humanin
Outcome
IncreaseSOD activity after ischemia/reperfusion
Study
n: not reported in source
Cortical neurons, ischemia and reperfusion
Comparator
Ischemia/reperfusion without humanin
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
pre-treatment with HN before I/R induced a significant increase in the activity of SOD as compared with the I/R group.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we found that 4 h ischemia and 24 h reperfusion induced a significant increase in lactate dehydrogenase (LDH) release, malondialdehyde (MDA) formation and the number of karyopyknotic nuclei (4',6-diamidino-2-phenylindole dihydrochloride nuclear dyeing) and a decrease in the num…
Report a problemFND-2193573106
07LabIn vitro (cells)Mechanism
In cortical neurons exposed to ischemia and reperfusion, the protective effect of humanin was concentration dependent.
In plain wordsIn lab tests on neurons, the protective effect of humanin was larger at higher concentrations.
Peptide
Humanin
Outcome
Not applicableConcentration dependence of humanin protection
Study
n: not reported in source
Cortical neurons, ischemia and reperfusion
Comparator
Ischemia/reperfusion without humanin
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
that the protective effect of HN on neurons against I/R is concentration-dependent.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we found that 4 h ischemia and 24 h reperfusion induced a significant increase in lactate dehydrogenase (LDH) release, malondialdehyde (MDA) formation and the number of karyopyknotic nuclei (4',6-diamidino-2-phenylindole dihydrochloride nuclear dyeing) and a decrease in the num…
Report a problemFND-2193573107

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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