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Study · In vitro (cells) · chicken · 2011

9 results

Effects of kisspeptin-10 on progesterone secretion in cultured chicken ovarian granulosa cells from preovulatory (F1-F3) follicles.

Xiao Y, Ni Y, Huang Y, Wu J, Grossmann R, Zhao R

Peptides8 Sept 2011Cited by 52 (Europe PMC)

PMID21924307 (opens in a new tab)DOI10.1016/j.peptides.2011.09.001 (opens in a new tab)PepBankPUB-21924307
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    Among 10, 100 and 1000 nM, 100 nM kisspeptin‑10 for 24 h increased progesterone secretion by chicken granulosa cells from F1 to F3 follicles.

    In plain wordsIn cells from hen ovary follicles, kisspeptin‑10 at 100 nM raised progesterone release after 24 hours.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseProgesterone secretion at 24 h
    Study

    chickenn: not reported in source

    Cultured granulosa cells from preovulatory (F1-F3) follicles of hens
    Comparator
    Untreated control
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 nM · 24 hAs given in this study (chicken).

    Measurements

    Tested concentration
    10 to 1000 nM
    Kp-10

    Source sentences

    Summary
    Among 10, 100 and 1000 nM concentrations tested, 100 nM Kp-10 treated for 24h significantly increased P(4) secretion in granulosa cells from F(1) to F(3) follicles.
    1 context sentence
    Summary · context
    The effect of kisspeptin-10 (Kp-10) on the secretion of progesterone (P(4)) was investigated in cultured granulosa cells from F(1) to F(3) follicles of hens.
  2. 02LabIn vitro (cells)Efficacy outcome

    After 24 h and 48 h, 100 nM kisspeptin‑10 increased progesterone secretion by chicken granulosa cells compared with control.

    In plain wordsIn cells from hen ovary follicles, kisspeptin‑10 raised progesterone release after 24 and 48 hours compared with untreated cells.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseProgesterone secretion at 24 h and 48 h
    Study

    chickenn: not reported in source

    Cultured granulosa cells from preovulatory (F1-F3) follicles of hens
    Comparator
    Untreated control
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 nM · 24 h and 48 hAs given in this study (chicken).

    Source sentences

    Summary
    After 24h and 48 h of treatment, 100 nM Kp-10 showed a significant increase in P(4) secretion
    2 context sentences
    Summary · context
    (P<0.05).
    Summary · context
    The effect of kisspeptin-10 (Kp-10) on the secretion of progesterone (P(4)) was investigated in cultured granulosa cells from F(1) to F(3) follicles of hens.
  3. 03LabIn vitro (cells)Efficacy outcome

    After 72 h, kisspeptin‑10 decreased progesterone secretion by chicken granulosa cells compared with control.

    In plain wordsIn cells from hen ovary follicles, kisspeptin‑10 lowered progesterone release after 72 hours compared with untreated cells.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseProgesterone secretion at 72 h
    Study

    chickenn: not reported in source

    Cultured granulosa cells from preovulatory (F1-F3) follicles of hens
    Comparator
    Untreated control
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 nM · 72 hAs given in this study (chicken).

    Source sentences

    Summary
    while after 72 h of treatment P(4) secretion was markedly decreased by Kp-10 compared to the control group (P<0.05)
    1 context sentence
    Summary · context
    The effect of kisspeptin-10 (Kp-10) on the secretion of progesterone (P(4)) was investigated in cultured granulosa cells from F(1) to F(3) follicles of hens.
  4. 04LabIn vitro (cells)Efficacy outcome

    In F1 and F2/3 granulosa cells, 100 nM kisspeptin‑10 for 24 h increased cell viability.

    In plain wordsIn cells from hen ovary follicles, kisspeptin‑10 at 100 nM raised cell viability after 24 hours.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGranulosa cell viability at 24 h
    Study

    chickenn: not reported in source

    Cultured granulosa cells from preovulatory (F1-F3) follicles of hens
    Comparator
    Untreated control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 nM · 24 hAs given in this study (chicken).

    Source sentences

    Summary
    F(1) and F(2/3) cells treated with 100 nM Kp-10 for 24h showed significantly increased viability (P<0.05)
    1 context sentence
    Summary · context
    The effect of kisspeptin-10 (Kp-10) on the secretion of progesterone (P(4)) was investigated in cultured granulosa cells from F(1) to F(3) follicles of hens.
  5. 05LabIn vitro (cells)Mechanism

    Kisspeptin‑10 at 100 nM for 24 h up-regulated StAR gene expression in F1 and F2/3 granulosa cells.

    In plain wordsIn cells from hen ovary follicles, kisspeptin‑10 raised activity of the StAR gene, which helps make progesterone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseStAR mRNA expression
    Study

    chickenn: not reported in source

    Cultured granulosa cells from preovulatory (F1-F3) follicles of hens
    Comparator
    Untreated control
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 nM · 24 hAs given in this study (chicken).

    Source sentences

    Summary
    Real-time PCR results showed that the gene expression of the steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage (P450scc) and the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) in F(1) and F(2/3) granulosa cells was significantly up-regulated by 24h-100 nM Kp-10 trea…
    1 context sentence
    Summary · context
    The effect of kisspeptin-10 (Kp-10) on the secretion of progesterone (P(4)) was investigated in cultured granulosa cells from F(1) to F(3) follicles of hens.
  6. 06LabIn vitro (cells)Mechanism

    Kisspeptin‑10 at 100 nM for 24 h up-regulated P450scc gene expression in F1 and F2/3 granulosa cells.

    In plain wordsIn cells from hen ovary follicles, kisspeptin‑10 raised activity of the P450scc gene, which helps make progesterone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseP450scc mRNA expression
    Study

    chickenn: not reported in source

    Cultured granulosa cells from preovulatory (F1-F3) follicles of hens
    Comparator
    Untreated control
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 nM · 24 hAs given in this study (chicken).

    Source sentences

    Summary
    Real-time PCR results showed that the gene expression of the steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage (P450scc) and the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) in F(1) and F(2/3) granulosa cells was significantly up-regulated by 24h-100 nM Kp-10 trea…
    1 context sentence
    Summary · context
    The effect of kisspeptin-10 (Kp-10) on the secretion of progesterone (P(4)) was investigated in cultured granulosa cells from F(1) to F(3) follicles of hens.
  7. 07LabIn vitro (cells)Mechanism

    Kisspeptin‑10 at 100 nM for 24 h up-regulated 3β-HSD gene expression in F1 and F2/3 granulosa cells.

    In plain wordsIn cells from hen ovary follicles, kisspeptin‑10 raised activity of the 3β-HSD gene, which helps make progesterone.

    Peptide
    Kisspeptin-10
    Outcome
    Increase3β-HSD mRNA expression
    Study

    chickenn: not reported in source

    Cultured granulosa cells from preovulatory (F1-F3) follicles of hens
    Comparator
    Untreated control
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 nM · 24 hAs given in this study (chicken).

    Source sentences

    Summary
    Real-time PCR results showed that the gene expression of the steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage (P450scc) and the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) in F(1) and F(2/3) granulosa cells was significantly up-regulated by 24h-100 nM Kp-10 trea…
    1 context sentence
    Summary · context
    The effect of kisspeptin-10 (Kp-10) on the secretion of progesterone (P(4)) was investigated in cultured granulosa cells from F(1) to F(3) follicles of hens.
  8. 08LabIn vitro (cells)Mechanism

    Protein content of StAR, P450scc and 3β-HSD did not differ between control and kisspeptin‑10 treated granulosa cells.

    In plain wordsIn cells from hen ovary follicles, kisspeptin‑10 did not change the protein amounts of three progesterone-making enzymes compared with untreated cells.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeStAR, P450scc and 3β-HSD protein content
    Study

    chickenn: not reported in source

    Cultured granulosa cells from preovulatory (F1-F3) follicles of hens
    Comparator
    Untreated control
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, there was no significant difference in StAR, P450scc and 3β-HSD protein content between control and the Kp-10 treated group (P>0.05).
    1 context sentence
    Summary · context
    The effect of kisspeptin-10 (Kp-10) on the secretion of progesterone (P(4)) was investigated in cultured granulosa cells from F(1) to F(3) follicles of hens.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 09LabEndogenous levelIn vitro (cells)Other

    Cultured chicken granulosa cells from F1 to F3 follicles stained for kisspeptin by immunocytochemistry.

    In plain wordsIn cells from hen ovary follicles, staining showed that the cells make the body's own kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin immunostaining in granulosa cells
    Study

    chickenn: not reported in source

    Cultured granulosa cells from preovulatory (F1-F3) follicles of hens
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The results showed that granulosa cells were stained with clear signals for kisspeptin using immunocytochemistry with the specific antibody against Kp-10.
    1 context sentence
    Summary · context
    The effect of kisspeptin-10 (Kp-10) on the secretion of progesterone (P(4)) was investigated in cultured granulosa cells from F(1) to F(3) follicles of hens.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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