Skip to content

Study · Animal study (in vivo) · rat · 2011

3 results

Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus.

Biagini G, Torsello A, Marinelli C, Gualtieri F, Vezzali R, Coco S, Bresciani E, Locatelli V

European journal of pharmacology2 Sept 2011Cited by 28 (Europe PMC)

PMID21914437 (opens in a new tab)DOI10.1016/j.ejphar.2011.08.020 (opens in a new tab)PepBankPUB-21914437
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats given pilocarpine, hexarelin pretreatment prevented progression to status epilepticus.

    In plain wordsIn rats given a seizure-inducing drug, hexarelin pretreatment stopped seizures from progressing to continuous seizures.

    Peptide
    Hexarelin
    Outcome
    DecreaseProgression to status epilepticus (pilocarpine)
    Study

    ratn: not reported in source

    pilocarpine- or kainate-induced status epilepticus
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    330 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    Hexarelin and EP-80317 were both able to prevent progression to status epilepticus in pilocarpine-treated rats (P<0.05).
    2 context sentences
    Summary · context
    Firstly, in three independent experiments, before receiving pilocarpine (380 mg/kg, i.p.), rats were pretreated with one among ghrelin (1.5mg/kg), desacyl-ghrelin (1.5mg/kg), hexarelin (330 μg/kg), EP-80317 (330 μg/kg), JMV-1843 (330 μg/kg), JMV-2959 (330 μg/kg) or saline.
    Summary · context
    In this study we aimed to characterize the anticonvulsive activity of ghrelin and other growth hormone secretagogue receptor 1a (GHSR(1a)) ligands in rats exposed to status epilepticus induced by pilocarpine or kainate.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats given kainate, hexarelin pretreatment did not change latency to status epilepticus.

    In plain wordsIn rats given a seizure-inducing drug, hexarelin pretreatment did not delay the start of continuous seizures.

    Peptide
    Hexarelin
    Outcome
    No significant changeLatency to status epilepticus (kainate)
    Study

    ratn: not reported in source

    pilocarpine- or kainate-induced status epilepticus
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    330 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    whereas hexarelin and EP-80317 did not display any effect.
    2 context sentences
    Summary · context
    Secondly, in the fourth experiment, rats were pretreated with i.p. ghrelin, desacyl-ghrelin, hexarelin, EP-80317 or saline, followed by kainate (15 mg/kg, i.p.).
    Summary · context
    In this study we aimed to characterize the anticonvulsive activity of ghrelin and other growth hormone secretagogue receptor 1a (GHSR(1a)) ligands in rats exposed to status epilepticus induced by pilocarpine or kainate.

Studies that did not test the peptide alone1

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 03AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Efficacy outcome

    In rats given pilocarpine, almost all GHSR(1a) ligands pooled, hexarelin among those tested, prevented mortality, which occurred only with saline or JMV-2959.

    In plain wordsIn rats given a seizure-inducing drug, almost all tested ligands of this receptor prevented death. Results were not reported for hexarelin alone.

    Peptide
    Hexarelin
    Outcome
    DecreasePilocarpine-induced mortality across GHSR(1a) ligands
    Study

    ratn: not reported in source

    pilocarpine- or kainate-induced status epilepticus
    Outcome group
    Mortality · Nervous system and cognition

    Source sentences

    Summary
    Almost all GHSR(1a) ligands prevented pilocarpine-induced mortality, which was observed only in rats pretreated with saline or JMV-2959.
    1 context sentence
    Summary · context
    In this study we aimed to characterize the anticonvulsive activity of ghrelin and other growth hormone secretagogue receptor 1a (GHSR(1a)) ligands in rats exposed to status epilepticus induced by pilocarpine or kainate.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.