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Study · Animal study (in vivo) · mouse · 2012

4 results

Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes.

Zhou B, Honor LB, Ma Q, Oh JH, Lin RZ, Melero-Martin JM, von Gise A, Zhou P, Hu T, He L, Wu KH, Zhang H, Zhang Y, Pu WT

Journal of molecular and cellular cardiology26 Aug 2011Cited by 97 (Europe PMC)

PMID21907210 (opens in a new tab)PMCIDPMC3664360 (opens in a new tab)DOI10.1016/j.yjmcc.2011.08.020 (opens in a new tab)PepBankPUB-21907210
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice after myocardial infarction, TB4 treatment significantly increased the thickness of the epicardium.

    In plain wordsIn mice after a heart attack, TB4 treatment made the outer heart layer thicker.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEpicardium thickness after MI
    Study

    mousen: not reported in source

    post-myocardial infarction, epicardial lineage tracing
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    we found post-MI TB4 treatment significantly increased the thickness of epicardium and coronary capillary density.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice after myocardial infarction, TB4 treatment significantly increased coronary capillary density.

    In plain wordsIn mice after a heart attack, TB4 treatment increased the density of small heart blood vessels.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCoronary capillary density after MI
    Study

    mousen: not reported in source

    post-myocardial infarction, epicardial lineage tracing
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    we found post-MI TB4 treatment significantly increased the thickness of epicardium and coronary capillary density
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice after myocardial infarction treated with TB4, epicardium-derived cells did not adopt a cardiomyocyte fate.

    In plain wordsIn mice after a heart attack, TB4 did not turn outer heart layer cells into heart muscle cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeEpicardium-derived cells adopting cardiomyocyte fate
    Study

    mousen: not reported in source

    post-myocardial infarction, epicardial lineage tracing
    Outcome group
    Heart repair and regeneration · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, epicardium-derived cells did not adopt cardiomyocyte fate, nor did they migrate into myocardium to become coronary endothelial cells.
    1 context sentence
    Summary · context
    Here we tested if TB4 treatment after MI could reprogram epicardium into cardiomyocytes and augment the epicardium's injury response.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice after myocardial infarction treated with TB4, epicardium-derived cells did not migrate into the myocardium to become coronary endothelial cells.

    In plain wordsIn mice after a heart attack, TB4 did not make outer heart layer cells move into the heart muscle and become blood vessel lining cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeEpicardium-derived cells becoming coronary endothelial cells
    Study

    mousen: not reported in source

    post-myocardial infarction, epicardial lineage tracing
    Outcome group
    Heart repair and regeneration · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, epicardium-derived cells did not adopt cardiomyocyte fate, nor did they migrate into myocardium to become coronary endothelial cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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