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Study · Animal study (in vivo) · mouse · 2011

5 results

Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function.

Caton PW, Kieswich J, Yaqoob MM, Holness MJ, Sugden MC

Diabetologia8 Sept 2011Cited by 116 (Europe PMC)

PMID21901281 (opens in a new tab)DOI10.1007/s00125-011-2288-0 (opens in a new tab)PepBankPUB-21901281
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In fructose-rich diet-fed mice, NMN lowered islet Il1b expression.

    In plain wordsIn mice fed a fructose-rich diet, NMN lowered islet Il1b expression.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseIslet Il1b expression
    Study

    mousen: not reported in source

    Fructose-rich diet-fed mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN administration lowered Il1b expression and restored suppressed insulin secretion in FRD-fed mice.
    1 context sentence
    Summary · context
    Acute effects of NMN on cytokine-mediated islet dysfunction were examined in islets incubated with TNFα and IL1β, and in mice fed a fructose-rich diet (FRD) for 16 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In fructose-rich diet-fed mice, NMN restored suppressed insulin secretion.

    In plain wordsIn mice fed a fructose-rich diet, NMN restored suppressed insulin release.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseInsulin secretion
    Study

    mousen: not reported in source

    Fructose-rich diet-fed mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN administration lowered Il1b expression and restored suppressed insulin secretion in FRD-fed mice.
    1 context sentence
    Summary · context
    Acute effects of NMN on cytokine-mediated islet dysfunction were examined in islets incubated with TNFα and IL1β, and in mice fed a fructose-rich diet (FRD) for 16 weeks.
  3. 03AnimalOther designMechanism

    In mouse islet dysfunction experiments, changes in islet function corresponded with changes in markers of islet function and differentiation.

    In plain wordsIn mouse experiments, changes in islet function occurred with changes in markers of islet function and differentiation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedMarkers of islet function and differentiation
    Study

    mousen: not reported in source

    Mouse islet dysfunction experiments
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The changes in islet function corresponded with changes in key markers of islet function and differentiation.
    1 context sentence
    Summary · context
    Acute effects of NMN on cytokine-mediated islet dysfunction were examined in islets incubated with TNFα and IL1β, and in mice fed a fructose-rich diet (FRD) for 16 weeks.
  4. 04LabEx vivo tissueEfficacy outcome

    In mouse islets cultured with pro-inflammatory cytokines, NMN restored insulin secretion.

    In plain wordsIn lab tests of mouse islets exposed to inflammatory cytokines, NMN restored insulin release.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseInsulin secretion
    Study

    mousen: not reported in source

    Islets cultured with TNFα and IL1β
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN also restored insulin secretion in islets cultured with pro-inflammatory cytokines.
    1 context sentence
    Summary · context
    Acute effects of NMN on cytokine-mediated islet dysfunction were examined in islets incubated with TNFα and IL1β, and in mice fed a fructose-rich diet (FRD) for 16 weeks.

Studies that did not test the peptide alone1

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 05AnimalNot a test of NMN (nicotinamide mononucleotide) aloneOther designMechanism

    In mouse islet dysfunction experiments, sirtuin 1 inhibition partially blocked the anti-inflammatory effects of NMN.

    In plain wordsIn mouse experiments, blocking sirtuin 1 partly blocked the anti-inflammatory effects of NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSirtuin 1 dependence of anti-inflammatory effects
    Study

    mousen: not reported in source

    Mouse islet dysfunction experiments
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    The anti-inflammatory effects of NMN were partially blocked by inhibition of sirtuin 1.
    1 context sentence
    Summary · context
    Acute effects of NMN on cytokine-mediated islet dysfunction were examined in islets incubated with TNFα and IL1β, and in mice fed a fructose-rich diet (FRD) for 16 weeks.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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