Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers.

Allen J, Bradley RD

Journal of alternative and complementary medicine (New York, N.Y.)1 Sept 2011Cited by 110 (Europe PMC)

PMID21875351PMCIDPMC3162377DOI10.1089/acm.2010.0716PepBankPUB-21875351

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialMechanism
In healthy adults, oral glutathione did not significantly change urinary F2-isoprostanes versus placebo at week 4.
In plain wordsIn healthy adults, oral glutathione did not significantly change urinary F2-isoprostanes versus placebo.
Peptide
Glutathione
Outcome
No significant changeUrinary F2-isoprostanes
Study
n = 39
Comparator
Placebo
Analysis
Primary
Outcome group
Oxidative stress · Whole body
Studied dose
500 mg twice daily · oral · 4 weeksAs given in this study (human).
Measurements
P value
0.38
between groups
Creatinine-standardized urinary F2-isoprostanes change
0 ng/mg creatinine
First source-listed group at week 4, treatment assignment unspecified
Reported ± uncertainty for Creatinine-standardized urinary F2-isoprostanes change (type unspecified)
0.1 ng/mg creatinine
First source-listed group at week 4, treatment assignment unspecified, parent value 0.0 ng/mg creatinine
Creatinine-standardized urinary F2-isoprostanes change
0 ng/mg creatinine
Second source-listed group at week 4, treatment assignment unspecified
Reported ± uncertainty for Creatinine-standardized urinary F2-isoprostanes change (type unspecified)
0.1 ng/mg creatinine
Second source-listed group at week 4, treatment assignment unspecified, parent value 0.0 ng/mg creatinine
Source sentences
Summary
Changes in creatinine standardized F2-isoP (ng/mg creatinine) (0.0±0.1 versus 0.0±0.1, p=0.38) and 8-OHdG (μg/g creatinine) (-0.2±3.3 versus 1.0±3.2, p=0.27) were nonsignificant between groups at week 4.
3 context sentences(design, population, supporting numbers)
Summary · context
This was a randomized, double-blind, placebo-controlled clinical trial.
Summary · context
Forty (40) adult volunteers without acute or chronic disease participated in this study.
Summary · context
Oral GSH supplementation (500 mg twice daily) was given to the volunteers for 4 weeks.
Report a problemFND-2187535101
02HumanRandomized controlled trialMechanism
In healthy adults, oral glutathione did not significantly change urinary 8-OHdG versus placebo at week 4.
In plain wordsIn healthy adults, oral glutathione did not significantly change urinary 8-OHdG versus placebo.
Peptide
Glutathione
Outcome
No significant changeUrinary 8-OHdG
Study
n = 39
Comparator
Placebo
Analysis
Primary
Outcome group
Oxidative stress · Whole body
Studied dose
500 mg twice daily · oral · 4 weeksAs given in this study (human).
Measurements
P value
0.27
between groups
Creatinine-standardized urinary 8-OHdG change
−0.2 μg/g creatinine
First source-listed group at week 4, treatment assignment unspecified
Reported ± uncertainty for Creatinine-standardized urinary 8-OHdG change (type unspecified)
3.3 μg/g creatinine
First source-listed group at week 4, treatment assignment unspecified, parent value -0.2 μg/g creatinine
Creatinine-standardized urinary 8-OHdG change
1 μg/g creatinine
Second source-listed group at week 4, treatment assignment unspecified
Reported ± uncertainty for Creatinine-standardized urinary 8-OHdG change (type unspecified)
3.2 μg/g creatinine
Second source-listed group at week 4, treatment assignment unspecified, parent value 1.0 μg/g creatinine
Source sentences
Summary
Changes in creatinine standardized F2-isoP (ng/mg creatinine) (0.0±0.1 versus 0.0±0.1, p=0.38) and 8-OHdG (μg/g creatinine) (-0.2±3.3 versus 1.0±3.2, p=0.27) were nonsignificant between groups at week 4.
3 context sentences(design, population, supporting numbers)
Summary · context
This was a randomized, double-blind, placebo-controlled clinical trial.
Summary · context
Forty (40) adult volunteers without acute or chronic disease participated in this study.
Summary · context
Oral GSH supplementation (500 mg twice daily) was given to the volunteers for 4 weeks.
Report a problemFND-2187535102
03HumanRandomized controlled trialMechanism
In healthy adults, erythrocyte reduced glutathione remained unchanged with oral glutathione versus placebo.
In plain wordsIn healthy adults, red blood cell reduced glutathione remained unchanged with oral glutathione versus placebo.
Peptide
Glutathione
Outcome
No significant changeErythrocyte reduced glutathione
Study
n = 39
Comparator
Placebo
Outcome group
Oxidative stress · Whole body
Studied dose
500 mg twice daily · oral · 4 weeksAs given in this study (human).
Source sentences
Summary
Total reduced, oxidized, and ratio measures of GSH status were also unchanged.
4 context sentences(design, population, supporting numbers)
Summary · context
Changes in erythrocyte GSH concentrations, including total reduced glutathione (GSH), oxidized glutathione (GSSG), and their ratio (GSH:GSSG) were also measured by tandem liquid chromatography/mass spectrometry.
Summary · context
This was a randomized, double-blind, placebo-controlled clinical trial.
Summary · context
Forty (40) adult volunteers without acute or chronic disease participated in this study.
Summary · context
Oral GSH supplementation (500 mg twice daily) was given to the volunteers for 4 weeks.
Report a problemFND-2187535103
04HumanRandomized controlled trialMechanism
In healthy adults, erythrocyte oxidized glutathione remained unchanged with oral glutathione versus placebo.
In plain wordsIn healthy adults, red blood cell oxidized glutathione remained unchanged with oral glutathione versus placebo.
Peptide
Glutathione
Outcome
No significant changeErythrocyte oxidized glutathione
Study
n = 39
Comparator
Placebo
Outcome group
Oxidative stress · Whole body
Studied dose
500 mg twice daily · oral · 4 weeksAs given in this study (human).
Source sentences
Summary
Total reduced, oxidized, and ratio measures of GSH status were also unchanged.
4 context sentences(design, population, supporting numbers)
Summary · context
Changes in erythrocyte GSH concentrations, including total reduced glutathione (GSH), oxidized glutathione (GSSG), and their ratio (GSH:GSSG) were also measured by tandem liquid chromatography/mass spectrometry.
Summary · context
This was a randomized, double-blind, placebo-controlled clinical trial.
Summary · context
Forty (40) adult volunteers without acute or chronic disease participated in this study.
Summary · context
Oral GSH supplementation (500 mg twice daily) was given to the volunteers for 4 weeks.
Report a problemFND-2187535104
05HumanRandomized controlled trialMechanism
In healthy adults, erythrocyte GSH:GSSG ratio remained unchanged with oral glutathione versus placebo.
In plain wordsIn healthy adults, the red blood cell reduced-to-oxidized glutathione ratio remained unchanged with oral glutathione versus placebo.
Peptide
Glutathione
Outcome
No significant changeErythrocyte GSH:GSSG ratio
Study
n = 39
Comparator
Placebo
Outcome group
Oxidative stress · Whole body
Studied dose
500 mg twice daily · oral · 4 weeksAs given in this study (human).
Source sentences
Summary
Total reduced, oxidized, and ratio measures of GSH status were also unchanged.
4 context sentences(design, population, supporting numbers)
Summary · context
Changes in erythrocyte GSH concentrations, including total reduced glutathione (GSH), oxidized glutathione (GSSG), and their ratio (GSH:GSSG) were also measured by tandem liquid chromatography/mass spectrometry.
Summary · context
This was a randomized, double-blind, placebo-controlled clinical trial.
Summary · context
Forty (40) adult volunteers without acute or chronic disease participated in this study.
Summary · context
Oral GSH supplementation (500 mg twice daily) was given to the volunteers for 4 weeks.
Report a problemFND-2187535105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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