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Study · In vitro (cells) · mouse · 2011

2 results

Haploinsufficiency in the prometastasis Kiss1 receptor Gpr54 delays breast tumor initiation, progression, and lung metastasis.

Cho SG, Wang Y, Rodriguez M, Tan K, Zhang W, Luo J, Li D, Liu M

Cancer research18 Aug 2011Cited by 38 (Europe PMC)

PMID21852382 (opens in a new tab)PMCIDPMC4949591 (opens in a new tab)DOI10.1158/0008-5472.can-11-0329 (opens in a new tab)PepBankPUB-21852382
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In primary mouse mammary tumor cells, kisspeptin‑10 activation of Kiss1r resulted in RhoA activation through the Gαq-p63RhoGEF pathway.

    In plain wordsIn mouse breast tumor cells in the lab, kisspeptin‑10 switched on the RhoA signal.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseRhoA activation
    Study

    mousen: not reported in source

    Primary tumor cells from PyMT/Kiss1r(+/+) mice
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kiss1r activation in these cells, resulting from the addition of its ligand Kisspeptin-10, resulted in RhoA activation and RhoA-dependent gene expression through the Gαq-p63RhoGEF signaling pathway.
    1 context sentence
    Summary · context
    To confirm these effects and assess possible contributions of endogenous ligands, we isolated primary tumor cells from PyMT/Kiss1r(+/+) and PyMT/Kiss1r(+/-) mice and compared their phenotypes by in vitro and in vivo assays.
  2. 02LabIn vitro (cells)Mechanism

    In primary mouse mammary tumor cells, kisspeptin‑10 activation of Kiss1r resulted in RhoA-dependent gene expression.

    In plain wordsIn mouse breast tumor cells in the lab, kisspeptin‑10 raised the activity of genes controlled by RhoA.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseRhoA-dependent gene expression
    Study

    mousen: not reported in source

    Primary tumor cells from PyMT/Kiss1r(+/+) mice
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kiss1r activation in these cells, resulting from the addition of its ligand Kisspeptin-10, resulted in RhoA activation and RhoA-dependent gene expression through the Gαq-p63RhoGEF signaling pathway.
    1 context sentence
    Summary · context
    To confirm these effects and assess possible contributions of endogenous ligands, we isolated primary tumor cells from PyMT/Kiss1r(+/+) and PyMT/Kiss1r(+/-) mice and compared their phenotypes by in vitro and in vivo assays.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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