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Study · Animal study (in vivo) · mouse · 2012

5 results

Carnosine treatment largely prevents alterations of renal carnosine metabolism in diabetic mice.

Peters V, Schmitt CP, Zschocke J, Gross ML, Brismar K, Forsberg E

Amino acids11 Aug 2011Cited by 49 (Europe PMC)

PMID21833769 (opens in a new tab)DOI10.1007/s00726-011-1046-4 (opens in a new tab)PepBankPUB-21833769
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In diabetic mice, carnosine substantially decreased renal CN1 activity compared with untreated mice.

    In plain wordsIn diabetic mice, carnosine decreased kidney CN1 activity compared with untreated mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal CN1 activity
    Study

    mousen: not reported in source

    db/db diabetic mice
    Comparator
    Untreated db/db mice
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated · 4 weeksAs given in this study (mouse).

    Measurements

    Renal CN1 activity
    0.32 μmol/mg/h
    untreated db/db
    Renal CN1 activity
    0.05 μmol/mg/h
    treated db/db
    P value
    < 0.01
    comparison

    Source sentences

    Summary
    Carnosine treatment for 4 weeks substantially decreased renal CN1 activity in diabetic mice (0.32±0.3 in non-treated db/db vs. 0.05±0.05 μmol/mg/h in treated db/db mice; p<0.01) close to normal activities.
    1 context sentence
    Summary · context
    We now investigated the renal carnosinase metabolism in db/db mice.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In diabetic mice, carnosine significantly increased renal anserine concentrations compared with untreated mice.

    In plain wordsIn diabetic mice, carnosine increased kidney anserine concentrations compared with untreated mice.

    Peptide
    L-carnosine
    Outcome
    IncreaseRenal anserine concentration
    Study

    mousen: not reported in source

    db/db diabetic mice
    Comparator
    Untreated db/db mice
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    Dose not stated · 4 weeksAs given in this study (mouse).

    Measurements

    Renal anserine
    0.24 μmol/mg/h
    untreated db/db
    Renal anserine
    5.7 μmol/mg/h
    treated db/db

    Source sentences

    Summary
    Renal anserine concentrations increased significantly (0.24±0.2 in non-treated db/db vs. 5.7±1.2 μmol/mg/h in treated db/db mice; p<0.01)
    1 context sentence
    Summary · context
    We now investigated the renal carnosinase metabolism in db/db mice.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In diabetic mice, carnosine did not significantly change renal carnosine concentrations compared with untreated mice.

    In plain wordsIn diabetic mice, carnosine did not significantly change kidney carnosine concentrations compared with untreated mice.

    Peptide
    L-carnosine
    Outcome
    No significant changeRenal carnosine concentration
    Study

    mousen: not reported in source

    db/db diabetic mice
    Comparator
    Untreated db/db mice
    Outcome group
    Pharmacokinetics · Kidney and urinary
    Studied dose
    Dose not stated · 4 weeksAs given in this study (mouse).

    Measurements

    Renal carnosine
    53 nmol/mg protein
    untreated
    Renal carnosine
    61 nmol/mg protein
    treated

    Source sentences

    Summary
    while carnosine concentrations remained unaltered (53±6.4 in non-treated vs. 61±15 nmol/mg protein in treated db/db mice; p=n.s.).
    1 context sentence
    Summary · context
    We now investigated the renal carnosinase metabolism in db/db mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, carnosine halved proteinuria.

    In plain wordsIn diabetic mice, carnosine halved urinary protein loss compared with untreated mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseProteinuria
    Study

    mousen: not reported in source

    db/db diabetic mice
    Comparator
    Untreated db/db mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Further, carnosine treatment halved proteinuria and reduced vascular permeability to one-fifth in db/db mice.
    1 context sentence
    Summary · context
    We now investigated the renal carnosinase metabolism in db/db mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, carnosine reduced vascular permeability to one-fifth.

    In plain wordsIn diabetic mice, carnosine reduced blood vessel permeability to one-fifth compared with untreated mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseVascular permeability
    Study

    mousen: not reported in source

    db/db diabetic mice
    Comparator
    Untreated db/db mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Further, carnosine treatment halved proteinuria and reduced vascular permeability to one-fifth in db/db mice.
    1 context sentence
    Summary · context
    We now investigated the renal carnosinase metabolism in db/db mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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