Skip to content

Study · Animal study (in vivo) · rhesus monkey (macaca mulatta) · 2011

4 results

Evidence from the agonadal juvenile male rhesus monkey (Macaca mulatta) for the view that the action of neurokinin B to trigger gonadotropin-releasing hormone release is upstream from the kisspeptin receptor.

Ramaswamy S, Seminara SB, Plant TM

Neuroendocrinology10 Aug 2011Cited by 102 (Europe PMC)

PMID21832818 (opens in a new tab)PMCIDPMC3238032 (opens in a new tab)DOI10.1159/000329045 (opens in a new tab)PepBankPUB-21832818
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In agonadal juvenile male monkeys, continuous kisspeptin‑10 infusion desensitized the kisspeptin receptor; a bolus of kisspeptin‑10 then failed to elicit GnRH release.

    In plain wordsIn monkeys, a long kisspeptin‑10 infusion stopped the body from responding to a further kisspeptin‑10 dose with GnRH release.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseGnRH response to kisspeptin-10 bolus during continuous kisspeptin-10 infusion
    Study

    rhesus monkey (Macaca mulatta)n = 3

    Agonadal juvenile male monkeys with GnRH-primed pituitary
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 μg/h · intravenous infusion · 99 hoursAs given in this study (rhesus monkey (Macaca mulatta)).

    Source sentences

    Summary
    During the last 4 h of continuous kisspeptin-10 infusion, desensitization of KISS1R was confirmed by failure of an i.v. bolus of kisspeptin-10 to elicit GnRH release.
    2 context sentences
    Summary · context
    In the first experiment (n = 3), the kisspeptin receptor (KISS1R) was desensitized by a continuous 99-hour i.v. infusion of kisspeptin-10 (100 μg/h).
    Summary · context
    To address the hierarchy of the NKB and kisspeptin signaling pathways that are essential for GnRH release, two experiments were conducted using agonadal, juvenile male monkeys. Pituitary responsiveness to GnRH was first heightened by a pulsatile GnRH infusion to use the in situ pituitary as a bioassay for GnRH release.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In agonadal juvenile male monkeys, kisspeptin receptor desensitization by kisspeptin‑10 was associated with a markedly blunted GnRH response to senktide.

    In plain wordsIn monkeys, after kisspeptin‑10 infusion, the GnRH response to the neurokinin B agonist senktide was much weaker.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseGnRH response to senktide after kisspeptin receptor desensitization
    Study

    rhesus monkey (Macaca mulatta)n = 3

    Agonadal juvenile male monkeys with GnRH-primed pituitary
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 μg/h · intravenous infusion · 99 hoursAs given in this study (rhesus monkey (Macaca mulatta)).

    Source sentences

    Summary
    Desensitization of KISS1R was associated with a markedly blunted GnRH response to senktide.
    2 context sentences
    Summary · context
    In the first experiment (n = 3), the kisspeptin receptor (KISS1R) was desensitized by a continuous 99-hour i.v. infusion of kisspeptin-10 (100 μg/h).
    Summary · context
    To address the hierarchy of the NKB and kisspeptin signaling pathways that are essential for GnRH release, two experiments were conducted using agonadal, juvenile male monkeys. Pituitary responsiveness to GnRH was first heightened by a pulsatile GnRH infusion to use the in situ pituitary as a bioassay for GnRH release.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In agonadal juvenile male monkeys, the GnRH response to senktide was progressively restored during the 72 h after continuous kisspeptin‑10 ended.

    In plain wordsIn monkeys, the GnRH response to senktide came back step by step over 72 hours after kisspeptin‑10 infusion stopped.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseRecovery of GnRH response to senktide after kisspeptin-10 infusion ended
    Study

    rhesus monkey (Macaca mulatta)n = 3

    Agonadal juvenile male monkeys with GnRH-primed pituitary
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 μg/h · intravenous infusion · 99 hoursAs given in this study (rhesus monkey (Macaca mulatta)).

    Source sentences

    Summary
    The response to senktide was progressively restored during the 72 h following termination of continuous kisspeptin-10.
    2 context sentences
    Summary · context
    In the first experiment (n = 3), the kisspeptin receptor (KISS1R) was desensitized by a continuous 99-hour i.v. infusion of kisspeptin-10 (100 μg/h).
    Summary · context
    To address the hierarchy of the NKB and kisspeptin signaling pathways that are essential for GnRH release, two experiments were conducted using agonadal, juvenile male monkeys. Pituitary responsiveness to GnRH was first heightened by a pulsatile GnRH infusion to use the in situ pituitary as a bioassay for GnRH release.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 04AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism

    In agonadal juvenile male monkeys, desensitization of the neurokinin 3 receptor by senktide left the ability of kisspeptin to stimulate GnRH unimpaired.

    In plain wordsIn monkeys, blocking the neurokinin B receptor with senktide did not reduce the GnRH response to kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeGnRH response to kisspeptin after NK3R desensitization by senktide
    Study

    rhesus monkey (Macaca mulatta)n = 2

    Agonadal juvenile male monkeys with GnRH-primed pituitary
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    While a bolus of senktide during the last 3 h of continuous senktide administration failed to elicit GnRH release, thus confirming desensitization of NK3R, the ability of kisspeptin to stimulate GnRH was unimpaired.
    2 context sentences
    Summary · context
    An analogous design was employed in the second experiment (n = 2) to desensitize the NKB receptor (neurokinin 3 receptor, NK3R) by administration of a continuous 48-hour i.v. infusion of senktide (200 μg/h).
    Summary · context
    To address the hierarchy of the NKB and kisspeptin signaling pathways that are essential for GnRH release, two experiments were conducted using agonadal, juvenile male monkeys. Pituitary responsiveness to GnRH was first heightened by a pulsatile GnRH infusion to use the in situ pituitary as a bioassay for GnRH release.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.