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Study · Animal study (in vivo) · 2011

4 results

Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy.

Min K, Smuder AJ, Kwon OS, Kavazis AN, Szeto HH, Powers SK

Journal of applied physiology (Bethesda, Md. : 1985)4 Aug 2011Cited by 224 (Europe PMC)

PMID21817113 (opens in a new tab)PMCIDPMC3220313 (opens in a new tab)DOI10.1152/japplphysiol.00591.2011 (opens in a new tab)PepBankPUB-21817113
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In immobilized skeletal muscle, a mitochondrial-targeted antioxidant (SS‑31) attenuated the increase in mitochondrial ROS production.

    In plain wordsIn animals with an immobilized limb, SS‑31 reduced the rise in mitochondrial reactive oxygen species in muscle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseImmobilization-induced mitochondrial ROS production
    Study

    n: not reported in source

    Limb immobilization (14 days) skeletal muscle
    Comparator
    Immobilization without SS-31
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, treatment with a mitochondrial-targeted antioxidant attenuated the inactivity-induced increase in mitochondrial ROS production
    1 context sentence
    Summary · context
    Cause-and-effect was determined by administration of a novel mitochondrial-targeted antioxidant (SS-31) to prevent immobilization-induced mitochondrial ROS production in skeletal muscle fibers.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In immobilized skeletal muscle, SS‑31 prevented oxidative stress.

    In plain wordsIn animals with an immobilized limb, SS‑31 prevented oxidative stress in muscle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseImmobilization-induced oxidative stress
    Study

    n: not reported in source

    Limb immobilization (14 days) skeletal muscle
    Comparator
    Immobilization without SS-31
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, treatment with a mitochondrial-targeted antioxidant attenuated the inactivity-induced increase in mitochondrial ROS production and prevented oxidative stress
    1 context sentence
    Summary · context
    Cause-and-effect was determined by administration of a novel mitochondrial-targeted antioxidant (SS-31) to prevent immobilization-induced mitochondrial ROS production in skeletal muscle fibers.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In immobilized skeletal muscle, SS‑31 prevented protease activation.

    In plain wordsIn animals with an immobilized limb, SS‑31 prevented activation of muscle-breaking enzymes.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseImmobilization-induced protease activation
    Study

    n: not reported in source

    Limb immobilization (14 days) skeletal muscle
    Comparator
    Immobilization without SS-31
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, treatment with a mitochondrial-targeted antioxidant attenuated the inactivity-induced increase in mitochondrial ROS production and prevented oxidative stress, protease activation
    1 context sentence
    Summary · context
    Cause-and-effect was determined by administration of a novel mitochondrial-targeted antioxidant (SS-31) to prevent immobilization-induced mitochondrial ROS production in skeletal muscle fibers.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized skeletal muscle, SS‑31 prevented myofiber atrophy.

    In plain wordsIn animals with an immobilized limb, SS‑31 prevented shrinking of muscle fibres.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseImmobilization-induced myofiber atrophy
    Study

    n: not reported in source

    Limb immobilization (14 days) skeletal muscle
    Comparator
    Immobilization without SS-31
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, treatment with a mitochondrial-targeted antioxidant attenuated the inactivity-induced increase in mitochondrial ROS production and prevented oxidative stress, protease activation, and myofiber atrophy
    1 context sentence
    Summary · context
    Cause-and-effect was determined by administration of a novel mitochondrial-targeted antioxidant (SS-31) to prevent immobilization-induced mitochondrial ROS production in skeletal muscle fibers.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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