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Study · Animal study (in vivo) · rat · 2011

5 results

Kisspeptin activation of supraoptic nucleus neurons in vivo.

Scott V, Brown CH

Endocrinology2 Aug 2011Cited by 38 (Europe PMC)

PMID21810945 (opens in a new tab)DOI10.1210/en.2011-1181 (opens in a new tab)PepBankPUB-21810945
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In anaesthetized female rats, intravenous kisspeptin‑10 increased the firing rate of supraoptic oxytocin neurons.

    In plain wordsIn female rats, kisspeptin‑10 given into a vein made oxytocin-producing brain cells fire faster.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseOxytocin neuron firing rate after intravenous kisspeptin-10
    Study

    ratn: not reported in source

    urethane-anaesthetized female rats, in vivo single unit recording of supraoptic nucleus neurons
    Outcome group
    Brain and neuronal activity · Endocrine and hormones
    Studied dose
    100 μg · intravenousAs given in this study (rat).

    Measurements

    Oxytocin neuron firing rate
    3.7 spikes/sec
    before intravenous kisspeptin-10
    Oxytocin neuron firing rate
    4.7 spikes/sec
    after intravenous kisspeptin-10 100 μg

    Source sentences

    Summary
    Intravenous kisspeptin-10 (100 μg) increased the firing rate of oxytocin neurons from 3.7 ± 0.8 to 4.7 ± 0.8 spikes/sec (P = 0.0004
    1 context sentence
    Summary · context
    Because posterior pituitary hormone secretion is dependent on action potential (spike) discharge, we used in vivo extracellular single unit recording to determine the effects of kisspeptin-10 on supraoptic nucleus neurons in urethane-anaesthetized female rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In anaesthetized female rats, only a quarter of supraoptic vasopressin neurons responded to intravenous kisspeptin‑10, with a short high-frequency burst of firing.

    In plain wordsIn female rats, kisspeptin‑10 given into a vein caused a short burst in only about a quarter of vasopressin-producing brain cells.

    Peptide
    Kisspeptin-10
    Outcome
    MixedVasopressin neuron response to intravenous kisspeptin-10
    Study

    ratn: not reported in source

    urethane-anaesthetized female rats, in vivo single unit recording of supraoptic nucleus neurons
    Outcome group
    Brain and neuronal activity · Endocrine and hormones
    Studied dose
    100 μg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    but only a quarter of vasopressin neurons responded to iv kisspeptin-10, showing a short (15 spikes/sec) burst of firing.
    1 context sentence
    Summary · context
    Because posterior pituitary hormone secretion is dependent on action potential (spike) discharge, we used in vivo extracellular single unit recording to determine the effects of kisspeptin-10 on supraoptic nucleus neurons in urethane-anaesthetized female rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In anaesthetized female rats, intracerebroventricular kisspeptin‑10 did not alter oxytocin neuron firing rate.

    In plain wordsIn female rats, kisspeptin‑10 given into the brain did not change how fast oxytocin-producing cells fire.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeOxytocin neuron firing rate after intracerebroventricular kisspeptin-10
    Study

    ratn: not reported in source

    urethane-anaesthetized female rats, in vivo single unit recording of supraoptic nucleus neurons
    Outcome group
    Brain and neuronal activity · Endocrine and hormones
    Studied dose
    2 and 40 μg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    By contrast, intracerebroventricular kisspeptin-10 (2 and 40 μg) did not alter oxytocin or vasopressin neuron firing rate.
    1 context sentence
    Summary · context
    Because posterior pituitary hormone secretion is dependent on action potential (spike) discharge, we used in vivo extracellular single unit recording to determine the effects of kisspeptin-10 on supraoptic nucleus neurons in urethane-anaesthetized female rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In anaesthetized female rats, intracerebroventricular kisspeptin‑10 did not alter vasopressin neuron firing rate.

    In plain wordsIn female rats, kisspeptin‑10 given into the brain did not change how fast vasopressin-producing cells fire.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeVasopressin neuron firing rate after intracerebroventricular kisspeptin-10
    Study

    ratn: not reported in source

    urethane-anaesthetized female rats, in vivo single unit recording of supraoptic nucleus neurons
    Outcome group
    Brain and neuronal activity · Endocrine and hormones
    Studied dose
    2 and 40 μg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    By contrast, intracerebroventricular kisspeptin-10 (2 and 40 μg) did not alter oxytocin or vasopressin neuron firing rate.
    1 context sentence
    Summary · context
    Because posterior pituitary hormone secretion is dependent on action potential (spike) discharge, we used in vivo extracellular single unit recording to determine the effects of kisspeptin-10 on supraoptic nucleus neurons in urethane-anaesthetized female rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In anaesthetized female rats, intraperitoneal capsaicin, which desensitizes vagal afferents, prevented the intravenous kisspeptin‑10-induced increase of oxytocin neuron firing rate.

    In plain wordsIn female rats, blocking vagus nerve sensing stopped kisspeptin‑10 from speeding up oxytocin-producing cells.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeOxytocin neuron response to intravenous kisspeptin-10 after vagal afferent desensitization
    Study

    ratn: not reported in source

    urethane-anaesthetized female rats, in vivo single unit recording of supraoptic nucleus neurons
    Outcome group
    Brain and neuronal activity · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    To investigate the pathway involved in the peripheral action of kisspeptin-10, we used i.p. capsaicin to desensitize vagal afferents, which prevented the i.v. kisspeptin-10-induced increase of oxytocin neuron firing rate.
    1 context sentence
    Summary · context
    Because posterior pituitary hormone secretion is dependent on action potential (spike) discharge, we used in vivo extracellular single unit recording to determine the effects of kisspeptin-10 on supraoptic nucleus neurons in urethane-anaesthetized female rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:04 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

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