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Study · Animal study (in vivo) · rat · 2011

9 results

[Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats].

Mendzheritskiĭ AM, Karantysh GV, Ivonina KO

Advances in gerontology = Uspekhi gerontologii1 Jan 2011Cited by 1 (Europe PMC)

PMID21809624 (opens in a new tab)PepBankPUB-21809624
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, Pinealon before carotid artery occlusion increased behavioral dream.

    In plain wordsIn rats, Pinealon before carotid artery occlusion increased the behavior described as behavioral dream.

    Peptide
    Pinealon
    Outcome
    IncreaseBehavioral dream
    Study

    ratn: not reported in source

    Old rats with carotid artery occlusion
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Under Pinealon before occlusion of carotid arteries, behavioral dream has been increased and a position-finding behavior, a motivational behavior and a motor performance have been reduced.
    1 context sentence
    Summary · context
    The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, Pinealon before carotid artery occlusion reduced position-finding behavior.

    In plain wordsIn rats, Pinealon before carotid artery occlusion reduced position-finding behavior.

    Peptide
    Pinealon
    Outcome
    DecreasePosition-finding behavior
    Study

    ratn: not reported in source

    Old rats with carotid artery occlusion
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Under Pinealon before occlusion of carotid arteries, behavioral dream has been increased and a position-finding behavior, a motivational behavior and a motor performance have been reduced.
    1 context sentence
    Summary · context
    The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, Pinealon before carotid artery occlusion reduced motivational behavior.

    In plain wordsIn rats, Pinealon before carotid artery occlusion reduced motivational behavior.

    Peptide
    Pinealon
    Outcome
    DecreaseMotivational behavior
    Study

    ratn: not reported in source

    Old rats with carotid artery occlusion
    Outcome group
    Locomotor and behavioral activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Under Pinealon before occlusion of carotid arteries, behavioral dream has been increased and a position-finding behavior, a motivational behavior and a motor performance have been reduced.
    1 context sentence
    Summary · context
    The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, Pinealon before carotid artery occlusion reduced motor performance.

    In plain wordsIn rats, Pinealon before carotid artery occlusion reduced motor performance.

    Peptide
    Pinealon
    Outcome
    DecreaseMotor performance
    Study

    ratn: not reported in source

    Old rats with carotid artery occlusion
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Under Pinealon before occlusion of carotid arteries, behavioral dream has been increased and a position-finding behavior, a motivational behavior and a motor performance have been reduced.
    1 context sentence
    Summary · context
    The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In false-operated old rats, Pinealon moderately increased brain caspase-3 activity.

    In plain wordsIn false-operated rats, Pinealon moderately increased brain caspase activity.

    Peptide
    Pinealon
    Outcome
    IncreaseCaspase-3 activity in false-operated animals
    Study

    ratn: not reported in source

    False-operated old rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At introduction of Pinealon activity of caspase-3 moderately raises in false-operated animals and in a model of occlusion of carotid arteries.
    1 context sentence
    Summary · context
    The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In old rats with carotid artery occlusion, Pinealon moderately increased brain caspase-3 activity.

    In plain wordsIn rats with carotid artery occlusion, Pinealon moderately increased brain caspase activity.

    Peptide
    Pinealon
    Outcome
    IncreaseCaspase-3 activity after carotid artery occlusion
    Study

    ratn: not reported in source

    Old rats with carotid artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At introduction of Pinealon activity of caspase-3 moderately raises in false-operated animals and in a model of occlusion of carotid arteries.
    1 context sentence
    Summary · context
    The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, Cortexin before carotid artery occlusion increased behavioral dream time.

    In plain wordsIn rats, Cortexin before carotid artery blockage increased the reported behavioral dream time.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseBehavioral dream time
    Study

    ratn: not reported in source

    Old rats with carotid artery occlusion
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The rats that were introduced Cortexin before carotid arteries occlusion demonstrated the raise of behavioral dream time.
    1 context sentence
    Summary · context
    The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted.

Studies that did not test the peptide alone2

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 08AnimalNot a test of Pinealon aloneAnimal study (in vivo)Efficacy outcome

    In rats with modeled carotid artery occlusion, short peptides including Pinealon increased survival without a separate Pinealon estimate.

    In plain wordsIn rats with carotid artery occlusion, short peptides including Pinealon increased survival without a separate Pinealon result.

    Peptide
    Pinealon
    Outcome
    IncreaseSurvival rate
    Study

    ratn: not reported in source

    Old rats with carotid artery occlusion
    Outcome group
    Mortality · Whole body

    Source sentences

    Summary
    It is shown that introduction of short peptides promotes a survival rate of the animals that have modeled occlusion of carotid arteries.
    1 context sentence
    Summary · context
    The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted.

    In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pinealon.

  2. 09AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Efficacy outcome

    In old rats with carotid artery occlusion, short peptides promoted survival, without a separate Cortexin result.

    In plain wordsIn rats with blocked carotid arteries, short peptides improved survival. The abstract gives no separate Cortexin result.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseSurvival
    Study

    ratn: not reported in source

    Old rats with carotid artery occlusion
    Outcome group
    Mortality · Nervous system and cognition

    Source sentences

    Summary
    It is shown that introduction of short peptides promotes a survival rate of the animals that have modeled occlusion of carotid arteries.
    1 context sentence
    Summary · context
    The comparative research of effect of Pinealon and Cortexin on behavior and activity of caspase-3 in a brain of old rats in a model of carotid arteries occlusion was conducted.

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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