Skip to content

Study · Animal study (in vivo) · mouse · 2011

3 results

Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance.

Carter EA, Bonab AA, Goverman J, Paul K, Yerxa J, Tompkins RG, Fischman AJ

International journal of molecular medicine19 Jul 2011Cited by 16 (Europe PMC)

PMID21805045 (opens in a new tab)PMCIDPMC4090514 (opens in a new tab)DOI10.3892/ijmm.2011.752 (opens in a new tab)PepBankPUB-21805045
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with thermal injury, SS31 ameliorated burn-induced insulin resistance, whereas the inactive analogue SS20 did not.

    In plain wordsIn mice with burns, SS31 reduced insulin resistance. An inactive look-alike peptide did not.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseBurn-induced insulin resistance (oral glucose tolerance)
    Study

    mousen: not reported in source

    Mice with thermal injury
    Comparator
    Burned mice without SS31 (and SS20 inactive analogue)
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results of these studies demonstrate that SS31 but not SS20 ameliorated burn-induced insulin resistance.
    1 context sentence
    Summary · context
    Oral glucose tolerance tests (OGTT) were performed in 4 groups of 6 mice with thermal injury with or without pre-treatment with SS31 or SS20 and sham controls.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In burned mice, SS31 treatment markedly reduced the increased 18FDG uptake by brown adipose tissue.

    In plain wordsIn mice with burns, SS31 markedly lowered the raised glucose-tracer uptake in brown fat.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Decrease18FDG uptake by brown adipose tissue in burned mice
    Study

    mousen: not reported in source

    Mice with thermal injury
    Comparator
    Burned mice without SS31
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, SS31 treatment resulted in marked reduction in the increased 18FDG uptake by brown adipose tissue (BAT) in burned
    1 context sentence
    Summary · context
    Oral glucose tolerance tests (OGTT) were performed in 4 groups of 6 mice with thermal injury with or without pre-treatment with SS31 or SS20 and sham controls.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In cold-stressed mice, SS31 treatment did not reduce the increased 18FDG uptake by brown adipose tissue.

    In plain wordsIn cold-stressed mice, SS31 did not lower the raised glucose-tracer uptake in brown fat.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant change18FDG uptake by brown adipose tissue in cold-stressed mice
    Study

    mousen: not reported in source

    Cold-stressed mice
    Comparator
    Cold-stressed mice without SS31
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, SS31 treatment resulted in marked reduction in the increased 18FDG uptake by brown adipose tissue (BAT) in burned but not cold-stressed animals; suggesting that the stressors act by different mechanisms.
    2 context sentences
    Summary · context
    For comparison purposes, groups of 6 cold-stressed mice with and without SS31 treatment were also studied.
    Summary · context
    Oral glucose tolerance tests (OGTT) were performed in 4 groups of 6 mice with thermal injury with or without pre-treatment with SS31 or SS20 and sham controls.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.