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Study · In vitro (cells) · bovine · 2010

5 results

Protection of thymosin beta-4 on corneal endothelial cells from UVB-induced apoptosis.

Ho JH, Su Y, Chen KH, Lee OK

The Chinese journal of physiology1 Jun 2010Cited by 10 (Europe PMC)

PMID21793328 (opens in a new tab)DOI10.4077/cjp.2010.amh091 (opens in a new tab)PepBankPUB-21793328
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In bovine corneal endothelial cells, thymosin beta‑4 diminished the reactive oxygen species level elicited by UVB.

    In plain wordsIn cells, thymosin beta‑4 lowered the reactive oxygen species that UVB light caused in cow corneal cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseReactive oxygen species level after UVB
    Study

    bovinen: not reported in source

    Bovine corneal endothelial (BCE) cells
    Outcome group
    Oxidative stress · Eye
    Studied dose
    1 microg/mlAs given in this study (bovine).

    Source sentences

    Summary
    we found that Tbeta4 diminished the reactive oxygen species level in BCE cells elicited by UVB.
    1 context sentence
    Summary · context
    In this study, 1 microg/ml of Tbeta4 was added to BCE cells 2 h before low (12.5 mj/cm2) or high dosage (100 mj/cm2) UVB exposure.
  2. 02LabIn vitro (cells)Efficacy outcome

    In bovine corneal endothelial cells, thymosin beta‑4 protected viability under low-dose UVB exposure.

    In plain wordsIn cells, thymosin beta‑4 helped cow corneal cells stay alive after a low dose of UVB light.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCell viability after low-dose UVB
    Study

    bovinen: not reported in source

    Bovine corneal endothelial (BCE) cells
    Outcome group
    Cell viability and death · Eye
    Studied dose
    1 microg/mlAs given in this study (bovine).

    Source sentences

    Summary
    However, the protection of viability by Tbeta4 could only be detected under low-dose UVB exposure.
    1 context sentence
    Summary · context
    In this study, 1 microg/ml of Tbeta4 was added to BCE cells 2 h before low (12.5 mj/cm2) or high dosage (100 mj/cm2) UVB exposure.
  3. 03LabIn vitro (cells)Efficacy outcome

    In bovine corneal endothelial cells, protection of viability by thymosin beta‑4 was not detected under high-dose UVB exposure.

    In plain wordsIn cells, thymosin beta‑4 did not protect cow corneal cells from a high dose of UVB light.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCell viability after high-dose UVB
    Study

    bovinen: not reported in source

    Bovine corneal endothelial (BCE) cells
    Outcome group
    Cell viability and death · Eye
    Studied dose
    1 microg/mlAs given in this study (bovine).

    Source sentences

    Summary
    However, the protection of viability by Tbeta4 could only be detected under low-dose UVB exposure.
    1 context sentence
    Summary · context
    In this study, 1 microg/ml of Tbeta4 was added to BCE cells 2 h before low (12.5 mj/cm2) or high dosage (100 mj/cm2) UVB exposure.
  4. 04LabIn vitro (cells)Efficacy outcome

    In bovine corneal endothelial cells, thymosin beta‑4 protected against low-dose UVB-induced apoptosis, shown by caspase-9 activity and annexin V/propidium iodine staining.

    In plain wordsIn cells, thymosin beta‑4 protected cow corneal cells from cell death by a low dose of UVB light.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseApoptosis after low-dose UVB
    Study

    bovinen: not reported in source

    Bovine corneal endothelial (BCE) cells
    Outcome group
    Cell viability and death · Eye
    Studied dose
    1 microg/mlAs given in this study (bovine).

    Source sentences

    Summary
    Moreover, both caspase-9 activity and annexin V/propidium iodine staining demonstrated that Tbeta4 only protected BCE cells from low-dose UVB-induced apoptosis but not high-dose UVB-induced necrosis.
    1 context sentence
    Summary · context
    In this study, 1 microg/ml of Tbeta4 was added to BCE cells 2 h before low (12.5 mj/cm2) or high dosage (100 mj/cm2) UVB exposure.
  5. 05LabIn vitro (cells)Efficacy outcome

    In bovine corneal endothelial cells, thymosin beta‑4 did not protect against high-dose UVB-induced necrosis.

    In plain wordsIn cells, thymosin beta‑4 did not protect cow corneal cells from cell death by a high dose of UVB light.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeNecrosis after high-dose UVB
    Study

    bovinen: not reported in source

    Bovine corneal endothelial (BCE) cells
    Outcome group
    Cell viability and death · Eye
    Studied dose
    1 microg/mlAs given in this study (bovine).

    Source sentences

    Summary
    Moreover, both caspase-9 activity and annexin V/propidium iodine staining demonstrated that Tbeta4 only protected BCE cells from low-dose UVB-induced apoptosis but not high-dose UVB-induced necrosis.
    1 context sentence
    Summary · context
    In this study, 1 microg/ml of Tbeta4 was added to BCE cells 2 h before low (12.5 mj/cm2) or high dosage (100 mj/cm2) UVB exposure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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