GnRH agonist ovulation trigger and hCG-based, progesterone-free luteal support: a proof of concept study.

Kol S, Humaidan P, Itskovitz-Eldor J

Human reproduction (Oxford, England)21 Jul 2011Cited by 35 (Europe PMC)

PMID21784738DOI10.1093/humrep/der220PepBankPUB-21784738

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In normal responders with previous IVF failure, the triptorelin-trigger and hCG-support regimen yielded a mean of 6.7 oocytes.
In plain wordsIn women with previous IVF failure, the triptorelin-trigger and hCG-support regimen yielded a mean of 6.7 eggs.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableOocytes retrieved
Study
n = 15
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Oocytes
6.7
mean
Source sentences
Summary
The mean (± SD) numbers of oocytes and fertilized oocytes were 6.7 (± 2.5) and 3.6 (± 1.7), respectively.
4 context sentences(design, population, supporting numbers)
Summary · context
METHODS Normal responder patients who failed at least one previous IVF attempt, during which a conventional hCG trigger was used, were consecutively enrolled in the study.
Summary · context
A GnRH antagonist-based ovarian stimulation protocol was used in combination with a GnRHa trigger (Triptorelin 0.2 mg).
Summary · context
The luteal phase was supported with a total of two boluses of 1500 IU hCG: on the day of oocyte retrieval and 4 days later.
Summary · context
Neither progesterone nor estradiol was administered for luteal support.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2178473801
02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In normal responders with previous IVF failure, the triptorelin-trigger and hCG-support regimen yielded a mean of 3.6 fertilized oocytes.
In plain wordsIn women with previous IVF failure, the triptorelin-trigger and hCG-support regimen yielded a mean of 3.6 fertilized eggs.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableFertilized oocytes
Study
n = 15
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Fertilized oocytes
3.6
mean
Source sentences
Summary
The mean (± SD) numbers of oocytes and fertilized oocytes were 6.7 (± 2.5) and 3.6 (± 1.7), respectively.
4 context sentences(design, population, supporting numbers)
Summary · context
METHODS Normal responder patients who failed at least one previous IVF attempt, during which a conventional hCG trigger was used, were consecutively enrolled in the study.
Summary · context
A GnRH antagonist-based ovarian stimulation protocol was used in combination with a GnRHa trigger (Triptorelin 0.2 mg).
Summary · context
The luteal phase was supported with a total of two boluses of 1500 IU hCG: on the day of oocyte retrieval and 4 days later.
Summary · context
Neither progesterone nor estradiol was administered for luteal support.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2178473802
03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In normal responders with previous IVF failure, all 15 patients had embryo transfers after the triptorelin-trigger and hCG-support regimen.
In plain wordsIn women with previous IVF failure, all 15 patients had embryo transfers after the triptorelin-trigger and hCG-support regimen.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableEmbryo transfer
Study
n = 15
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Embryo transfers
15 patients
regimen
Source sentences
Summary
All 15 patients had embryo transfers and 11 patients conceived.
4 context sentences(design, population, supporting numbers)
Summary · context
METHODS Normal responder patients who failed at least one previous IVF attempt, during which a conventional hCG trigger was used, were consecutively enrolled in the study.
Summary · context
A GnRH antagonist-based ovarian stimulation protocol was used in combination with a GnRHa trigger (Triptorelin 0.2 mg).
Summary · context
The luteal phase was supported with a total of two boluses of 1500 IU hCG: on the day of oocyte retrieval and 4 days later.
Summary · context
Neither progesterone nor estradiol was administered for luteal support.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2178473803
04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In normal responders with previous IVF failure, 11 patients conceived after the triptorelin-trigger and hCG-support regimen.
In plain wordsIn women with previous IVF failure, 11 patients conceived after the triptorelin-trigger and hCG-support regimen.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableConception
Study
n = 15
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Conceived
11 patients
regimen
Source sentences
Summary
All 15 patients had embryo transfers and 11 patients conceived.
4 context sentences(design, population, supporting numbers)
Summary · context
METHODS Normal responder patients who failed at least one previous IVF attempt, during which a conventional hCG trigger was used, were consecutively enrolled in the study.
Summary · context
A GnRH antagonist-based ovarian stimulation protocol was used in combination with a GnRHa trigger (Triptorelin 0.2 mg).
Summary · context
The luteal phase was supported with a total of two boluses of 1500 IU hCG: on the day of oocyte retrieval and 4 days later.
Summary · context
Neither progesterone nor estradiol was administered for luteal support.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2178473804
05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialActivity measurement
In normal responders given the triptorelin-trigger and hCG-support regimen, mean serum estradiol was 6607 nmol/l at pregnancy testing.
In plain wordsIn women given the triptorelin-trigger and hCG-support regimen, mean blood estradiol was 6607 nmol/l at pregnancy testing.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableSerum estradiol at pregnancy test
Study
n = 15
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Estradiol
6607 nmol/l
pregnancy test
Source sentences
Summary
On the day of pregnancy test (14 days after retrieval), the mean serum E(2) and progesterone levels were 6607 (± 3789) and 182 (± 50) nmol/l, respectively.
4 context sentences(design, population, supporting numbers)
Summary · context
METHODS Normal responder patients who failed at least one previous IVF attempt, during which a conventional hCG trigger was used, were consecutively enrolled in the study.
Summary · context
A GnRH antagonist-based ovarian stimulation protocol was used in combination with a GnRHa trigger (Triptorelin 0.2 mg).
Summary · context
The luteal phase was supported with a total of two boluses of 1500 IU hCG: on the day of oocyte retrieval and 4 days later.
Summary · context
Neither progesterone nor estradiol was administered for luteal support.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2178473805
06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialActivity measurement
In normal responders given the triptorelin-trigger and hCG-support regimen, mean serum progesterone was 182 nmol/l at pregnancy testing.
In plain wordsIn women given the triptorelin-trigger and hCG-support regimen, mean blood progesterone was 182 nmol/l at pregnancy testing.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableSerum progesterone at pregnancy test
Study
n = 15
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Progesterone
182 nmol/l
pregnancy test
Source sentences
Summary
On the day of pregnancy test (14 days after retrieval), the mean serum E(2) and progesterone levels were 6607 (± 3789) and 182 (± 50) nmol/l, respectively.
4 context sentences(design, population, supporting numbers)
Summary · context
METHODS Normal responder patients who failed at least one previous IVF attempt, during which a conventional hCG trigger was used, were consecutively enrolled in the study.
Summary · context
A GnRH antagonist-based ovarian stimulation protocol was used in combination with a GnRHa trigger (Triptorelin 0.2 mg).
Summary · context
The luteal phase was supported with a total of two boluses of 1500 IU hCG: on the day of oocyte retrieval and 4 days later.
Summary · context
Neither progesterone nor estradiol was administered for luteal support.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2178473806
07HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In normal responders given the triptorelin-trigger and hCG-support regimen, seven pregnancies were ongoing.
In plain wordsIn women given the triptorelin-trigger and hCG-support regimen, seven pregnancies were ongoing.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableOngoing pregnancies
Study
n = 11
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Ongoing pregnancies
7 pregnancies
regimen
Source sentences
Summary
Of the pregnancies, seven are ongoing, while four ended as miscarriages.
4 context sentences(design, population, supporting numbers)
Summary · context
METHODS Normal responder patients who failed at least one previous IVF attempt, during which a conventional hCG trigger was used, were consecutively enrolled in the study.
Summary · context
A GnRH antagonist-based ovarian stimulation protocol was used in combination with a GnRHa trigger (Triptorelin 0.2 mg).
Summary · context
The luteal phase was supported with a total of two boluses of 1500 IU hCG: on the day of oocyte retrieval and 4 days later.
Summary · context
Neither progesterone nor estradiol was administered for luteal support.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2178473807
08HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialSafety outcome
In normal responders given the triptorelin-trigger and hCG-support regimen, four pregnancies ended as miscarriages.
In plain wordsIn women given the triptorelin-trigger and hCG-support regimen, four pregnancies ended as miscarriages.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableMiscarriage
Study
n = 11
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Miscarriages
4 pregnancies
regimen
Source sentences
Summary
Of the pregnancies, seven are ongoing, while four ended as miscarriages.
4 context sentences(design, population, supporting numbers)
Summary · context
METHODS Normal responder patients who failed at least one previous IVF attempt, during which a conventional hCG trigger was used, were consecutively enrolled in the study.
Summary · context
A GnRH antagonist-based ovarian stimulation protocol was used in combination with a GnRHa trigger (Triptorelin 0.2 mg).
Summary · context
The luteal phase was supported with a total of two boluses of 1500 IU hCG: on the day of oocyte retrieval and 4 days later.
Summary · context
Neither progesterone nor estradiol was administered for luteal support.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2178473808

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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