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Study · Animal study (in vivo) · mouse · 2008

7 results

Protective effect of carnosine against cisplatin-induced nephrotoxicity in mice.

Fouad AA, Morsy MA, Gomaa W

Environmental toxicology and pharmacology22 Oct 2007Cited by 39 (Europe PMC)

PMID21783865 (opens in a new tab)DOI10.1016/j.etap.2007.10.026 (opens in a new tab)PepBankPUB-21783865
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with cisplatin-induced renal damage, carnosine significantly reduced elevated blood urea nitrogen.

    In plain wordsIn mice with cisplatin-induced kidney damage, carnosine significantly reduced elevated blood urea nitrogen.

    Peptide
    L-carnosine
    Outcome
    DecreaseBlood urea nitrogen
    Study

    mousen: not reported in source

    cisplatin-induced acute renal damage
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    10 mg/kg/day · intraperitoneal · six consecutive daysAs given in this study (mouse).

    Source sentences

    Summary
    The results revealed that carnosine treatment significantly reduced blood urea nitrogen and serum creatinine levels elevated by cisplatin administration.
    2 context sentences
    Summary · context
    The nephroprotective effect of the natural antioxidant carnosine was evaluated in mice with cisplatin-induced acute renal damage, in which generation of reactive oxygen species plays a major role.
    Summary · context
    Carnosine was administered for six consecutive days in a dose of 10mg/kg/day, i.p., starting 3 days before cisplatin injection.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with cisplatin-induced renal damage, carnosine significantly reduced elevated serum creatinine.

    In plain wordsIn mice with cisplatin-induced kidney damage, carnosine significantly reduced elevated blood creatinine.

    Peptide
    L-carnosine
    Outcome
    DecreaseSerum creatinine
    Study

    mousen: not reported in source

    cisplatin-induced acute renal damage
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    10 mg/kg/day · intraperitoneal · six consecutive daysAs given in this study (mouse).

    Source sentences

    Summary
    The results revealed that carnosine treatment significantly reduced blood urea nitrogen and serum creatinine levels elevated by cisplatin administration.
    2 context sentences
    Summary · context
    The nephroprotective effect of the natural antioxidant carnosine was evaluated in mice with cisplatin-induced acute renal damage, in which generation of reactive oxygen species plays a major role.
    Summary · context
    Carnosine was administered for six consecutive days in a dose of 10mg/kg/day, i.p., starting 3 days before cisplatin injection.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, carnosine significantly attenuated the cisplatin-induced increase in renal cortical malondialdehyde.

    In plain wordsIn mice, carnosine significantly reduced the increase in kidney malondialdehyde caused by cisplatin.

    Peptide
    L-carnosine
    Outcome
    DecreaseMalondialdehyde
    Study

    mousen: not reported in source

    cisplatin-induced acute renal damage
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    10 mg/kg/day · intraperitoneal · six consecutive daysAs given in this study (mouse).

    Source sentences

    Summary
    Also, carnosine significantly attenuated cisplatin-induced increase in malondialdehyde and decrease in reduced glutathione, and catalase and superoxide dismutase activities in renal cortical homogenates.
    2 context sentences
    Summary · context
    The nephroprotective effect of the natural antioxidant carnosine was evaluated in mice with cisplatin-induced acute renal damage, in which generation of reactive oxygen species plays a major role.
    Summary · context
    Carnosine was administered for six consecutive days in a dose of 10mg/kg/day, i.p., starting 3 days before cisplatin injection.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, carnosine significantly attenuated the cisplatin-induced decrease in renal cortical reduced glutathione.

    In plain wordsIn mice, carnosine significantly reduced the loss of kidney reduced glutathione caused by cisplatin.

    Peptide
    L-carnosine
    Outcome
    IncreaseReduced glutathione
    Study

    mousen: not reported in source

    cisplatin-induced acute renal damage
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    10 mg/kg/day · intraperitoneal · six consecutive daysAs given in this study (mouse).

    Source sentences

    Summary
    Also, carnosine significantly attenuated cisplatin-induced increase in malondialdehyde and decrease in reduced glutathione, and catalase and superoxide dismutase activities in renal cortical homogenates.
    2 context sentences
    Summary · context
    The nephroprotective effect of the natural antioxidant carnosine was evaluated in mice with cisplatin-induced acute renal damage, in which generation of reactive oxygen species plays a major role.
    Summary · context
    Carnosine was administered for six consecutive days in a dose of 10mg/kg/day, i.p., starting 3 days before cisplatin injection.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, carnosine significantly attenuated the cisplatin-induced decrease in renal cortical catalase activity.

    In plain wordsIn mice, carnosine significantly reduced the loss of kidney catalase activity caused by cisplatin.

    Peptide
    L-carnosine
    Outcome
    IncreaseCatalase activity
    Study

    mousen: not reported in source

    cisplatin-induced acute renal damage
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    10 mg/kg/day · intraperitoneal · six consecutive daysAs given in this study (mouse).

    Source sentences

    Summary
    Also, carnosine significantly attenuated cisplatin-induced increase in malondialdehyde and decrease in reduced glutathione, and catalase and superoxide dismutase activities in renal cortical homogenates.
    2 context sentences
    Summary · context
    The nephroprotective effect of the natural antioxidant carnosine was evaluated in mice with cisplatin-induced acute renal damage, in which generation of reactive oxygen species plays a major role.
    Summary · context
    Carnosine was administered for six consecutive days in a dose of 10mg/kg/day, i.p., starting 3 days before cisplatin injection.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice, carnosine significantly attenuated the cisplatin-induced decrease in renal cortical superoxide dismutase activity.

    In plain wordsIn mice, carnosine significantly reduced the loss of kidney superoxide dismutase activity caused by cisplatin.

    Peptide
    L-carnosine
    Outcome
    IncreaseSuperoxide dismutase activity
    Study

    mousen: not reported in source

    cisplatin-induced acute renal damage
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    10 mg/kg/day · intraperitoneal · six consecutive daysAs given in this study (mouse).

    Source sentences

    Summary
    Also, carnosine significantly attenuated cisplatin-induced increase in malondialdehyde and decrease in reduced glutathione, and catalase and superoxide dismutase activities in renal cortical homogenates.
    2 context sentences
    Summary · context
    The nephroprotective effect of the natural antioxidant carnosine was evaluated in mice with cisplatin-induced acute renal damage, in which generation of reactive oxygen species plays a major role.
    Summary · context
    Carnosine was administered for six consecutive days in a dose of 10mg/kg/day, i.p., starting 3 days before cisplatin injection.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice, carnosine markedly ameliorated cisplatin-induced renal tubular necrosis.

    In plain wordsIn mice, carnosine markedly reduced kidney tubular tissue death caused by cisplatin.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal tubular necrosis
    Study

    mousen: not reported in source

    cisplatin-induced acute renal damage
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    10 mg/kg/day · intraperitoneal · six consecutive daysAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, histopathological examination and scoring showed that carnosine markedly ameliorated cisplatin-induced renal tubular necrosis.
    2 context sentences
    Summary · context
    The nephroprotective effect of the natural antioxidant carnosine was evaluated in mice with cisplatin-induced acute renal damage, in which generation of reactive oxygen species plays a major role.
    Summary · context
    Carnosine was administered for six consecutive days in a dose of 10mg/kg/day, i.p., starting 3 days before cisplatin injection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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