Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging.

Babizhayev MA, Deyev AI, Savel'yeva EL, Lankin VZ, Yegorov YE

The Journal of dermatological treatment14 Jul 2011Cited by 18 (Europe PMC)

PMID21756141DOI10.3109/09546634.2010.521812PepBankPUB-21756141

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

01HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In study participants, the Can-C Plus formulation significantly improved investigated skin parameters versus placebo during supplementation.
In plain wordsThe Can-C Plus formulation improved investigated skin parameters compared with placebo.
Peptide
L-carnosine
Outcome
Direction not reportedInvestigated skin parameters
Study
n = 42
Comparator
Placebo
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
During oral supplementation with stabilized from enzymatic hydrolysis carnosine (Can-C Plus® formulation), the skin parameters investigated showed a continuous and significant improvement in the active group during the 3 months of supplementation as compared to placebo.
1 context sentence(design, population, supporting numbers)
Summary · context
A 4-month randomized, double-blind, controlled study was undertaken including 42 subjects where the oral supplement of non-hydrolized carnosine (Can-C Plus® formulation) was tested against placebo for 3 months followed by a 1-month supplement-free period for both groups to assess lasting effects.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2175614101
02HumanNot a test of L-carnosine aloneRandomized controlled trialSafety outcome
In study participants, no treatment-related side effects were reported with the carnosine formulation.
In plain wordsNo treatment-related side effects were reported with the carnosine formulation.
Peptide
L-carnosine
Outcome
Not applicableTreatment-related side effects
Study
n = 42
Outcome group
Adverse events · Whole body
Source sentences
Summary
No treatment-related side effects were reported.
1 context sentence(design, population, supporting numbers)
Summary · context
A 4-month randomized, double-blind, controlled study was undertaken including 42 subjects where the oral supplement of non-hydrolized carnosine (Can-C Plus® formulation) was tested against placebo for 3 months followed by a 1-month supplement-free period for both groups to assess lasting effects.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2175614104
03HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In study participants, visual assessment showed improved overall skin appearance with the carnosine formulation.
In plain wordsVisual assessment showed improved skin appearance with the carnosine formulation.
Peptide
L-carnosine
Outcome
Direction not reportedOverall skin appearance
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Visual investigation showed improvement of the overall skin appearance and a reduction of fine lines.
1 context sentence(design, population, supporting numbers)
Summary · context
A 4-month randomized, double-blind, controlled study was undertaken including 42 subjects where the oral supplement of non-hydrolized carnosine (Can-C Plus® formulation) was tested against placebo for 3 months followed by a 1-month supplement-free period for both groups to assess lasting effects.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2175614102
04HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In study participants, visual assessment showed fewer fine lines with the carnosine formulation.
In plain wordsVisual assessment showed fewer fine lines with the carnosine formulation.
Peptide
L-carnosine
Outcome
DecreaseFine lines
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Visual investigation showed improvement of the overall skin appearance and a reduction of fine lines.
1 context sentence(design, population, supporting numbers)
Summary · context
A 4-month randomized, double-blind, controlled study was undertaken including 42 subjects where the oral supplement of non-hydrolized carnosine (Can-C Plus® formulation) was tested against placebo for 3 months followed by a 1-month supplement-free period for both groups to assess lasting effects.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2175614103
05LabNot a test of L-carnosine aloneIn vitro (cell-free)Activity measurement
In biochemical models, patented formulations including stabilized carnosine demonstrated transglycating activities.
In plain wordsIn lab tests, patented formulations including stabilized carnosine showed transglycating activity.
Peptide
L-carnosine
Outcome
Not applicableTransglycating activity
Study
n: not reported in source
Biochemical and model systems
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Carnosine stabilized from enzymatic hydrolysis, carcinine and leucyl-histidylhydrazide in patented formulations thereof, demonstrate the Schiff bases' transglycating activities concomitant with glycation site specific antioxidant activities
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2175614105
06LabNot a test of L-carnosine aloneIn vitro (cell-free)Activity measurement
In biochemical models, patented formulations including stabilized carnosine demonstrated glycation site specific antioxidant activities.
In plain wordsIn lab tests, patented formulations including stabilized carnosine showed antioxidant activity at glycation sites.
Peptide
L-carnosine
Outcome
Not applicableGlycation site specific antioxidant activity
Study
n: not reported in source
Biochemical and model systems
Outcome group
Oxidative stress · Pharmacology
Source sentences
Summary
Carnosine stabilized from enzymatic hydrolysis, carcinine and leucyl-histidylhydrazide in patented formulations thereof, demonstrate the Schiff bases' transglycating activities concomitant with glycation site specific antioxidant activities
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2175614106
07LabNot a test of L-carnosine aloneIn vitro (cell-free)Activity measurement
Patented formulations including stabilized carnosine showed protection of proprietary antioxidant enzymes in skin aging and diabetes lesions.
In plain wordsIn lab tests, patented formulations including stabilized carnosine showed protection of antioxidant enzymes.
Peptide
L-carnosine
Outcome
Not applicableAntioxidant enzyme protection
Study
n: not reported in source
Biochemical and model systems
Outcome group
Oxidative stress · Skin and wound
Source sentences
Summary
Carnosine stabilized from enzymatic hydrolysis, carcinine and leucyl-histidylhydrazide in patented formulations thereof, demonstrate the Schiff bases' transglycating activities concomitant with glycation site specific antioxidant activities and protection of proprietary antioxidant enzymes in the sk…
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2175614107

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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