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Study · Animal study (in vivo) · rat · 2011

8 results

Carnosine pretreatment protects against hypoxia-ischemia brain damage in the neonatal rat model.

Zhang X, Song L, Cheng X, Yang Y, Luan B, Jia L, Xu F, Zhang Z

European journal of pharmacology16 Jun 2011Cited by 48 (Europe PMC)

PMID21693116 (opens in a new tab)DOI10.1016/j.ejphar.2011.06.003 (opens in a new tab)PepBankPUB-21693116
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with hypoxia-ischemia, carnosine pretreatment significantly reduced infarct volume.

    In plain wordsIn neonatal rats with hypoxia-ischemia, carnosine pretreatment reduced infarct volume.

    Peptide
    L-carnosine
    Outcome
    DecreaseInfarct volume
    Study

    ratn: not reported in source

    Neonatal hypoxia-ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that pretreatment with carnosine significantly reduced the infarct volume and the number of terminal-deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells in the hypoxia-ischemia brain.
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal day 7 (P7).
    Summary · context
    Carnosine (250 mg/kg) was administered intraperitoneally, 30 min prior to hypoxia-ischemia induction.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with hypoxia-ischemia, carnosine pretreatment significantly reduced TUNEL-positive cells.

    In plain wordsIn neonatal rats with hypoxia-ischemia, carnosine pretreatment reduced cells with a marker of cell death.

    Peptide
    L-carnosine
    Outcome
    DecreaseTUNEL-positive cells
    Study

    ratn: not reported in source

    Neonatal hypoxia-ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that pretreatment with carnosine significantly reduced the infarct volume and the number of terminal-deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells in the hypoxia-ischemia brain.
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal day 7 (P7).
    Summary · context
    Carnosine (250 mg/kg) was administered intraperitoneally, 30 min prior to hypoxia-ischemia induction.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with hypoxia-ischemia, carnosine inhibited apoptosis-inducing factor mRNA expression.

    In plain wordsIn rats with hypoxia-ischemia, carnosine reduced expression of the apoptosis-inducing factor gene.

    Peptide
    L-carnosine
    Outcome
    DecreaseApoptosis-inducing factor mRNA
    Study

    ratn: not reported in source

    Neonatal hypoxia-ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine also inhibited mRNA expression of apoptosis-inducing factor(AIF) and caspase-3, which was accompanied by an increase in superoxide dismutase(SOD)activity and a decrease in the malondialdehyde(MDA)level in carnosine-treated rats.
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal day 7 (P7).
    Summary · context
    Carnosine (250 mg/kg) was administered intraperitoneally, 30 min prior to hypoxia-ischemia induction.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with hypoxia-ischemia, carnosine inhibited caspase-3 mRNA expression.

    In plain wordsIn rats with hypoxia-ischemia, carnosine reduced expression of the caspase-3 gene.

    Peptide
    L-carnosine
    Outcome
    DecreaseCaspase-3 mRNA
    Study

    ratn: not reported in source

    Neonatal hypoxia-ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine also inhibited mRNA expression of apoptosis-inducing factor(AIF) and caspase-3, which was accompanied by an increase in superoxide dismutase(SOD)activity and a decrease in the malondialdehyde(MDA)level in carnosine-treated rats.
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal day 7 (P7).
    Summary · context
    Carnosine (250 mg/kg) was administered intraperitoneally, 30 min prior to hypoxia-ischemia induction.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with hypoxia-ischemia, carnosine increased superoxide dismutase activity.

    In plain wordsIn rats with hypoxia-ischemia, carnosine increased superoxide dismutase activity.

    Peptide
    L-carnosine
    Outcome
    IncreaseSuperoxide dismutase activity
    Study

    ratn: not reported in source

    Neonatal hypoxia-ischemia
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine also inhibited mRNA expression of apoptosis-inducing factor(AIF) and caspase-3, which was accompanied by an increase in superoxide dismutase(SOD)activity and a decrease in the malondialdehyde(MDA)level in carnosine-treated rats.
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal day 7 (P7).
    Summary · context
    Carnosine (250 mg/kg) was administered intraperitoneally, 30 min prior to hypoxia-ischemia induction.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with hypoxia-ischemia, carnosine decreased malondialdehyde levels.

    In plain wordsIn rats with hypoxia-ischemia, carnosine decreased malondialdehyde levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseMalondialdehyde level
    Study

    ratn: not reported in source

    Neonatal hypoxia-ischemia
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine also inhibited mRNA expression of apoptosis-inducing factor(AIF) and caspase-3, which was accompanied by an increase in superoxide dismutase(SOD)activity and a decrease in the malondialdehyde(MDA)level in carnosine-treated rats.
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal day 7 (P7).
    Summary · context
    Carnosine (250 mg/kg) was administered intraperitoneally, 30 min prior to hypoxia-ischemia induction.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with hypoxia-ischemia, carnosine improved spatial learning ability.

    In plain wordsIn rats with hypoxia-ischemia, carnosine improved spatial learning.

    Peptide
    L-carnosine
    Outcome
    IncreaseSpatial learning
    Study

    ratn: not reported in source

    Neonatal hypoxia-ischemia
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, carnosine also improved the spatial learning and memory abilities of rats declined due to hypoxia-ischemia.
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal day 7 (P7).
    Summary · context
    Carnosine (250 mg/kg) was administered intraperitoneally, 30 min prior to hypoxia-ischemia induction.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with hypoxia-ischemia, carnosine improved memory ability.

    In plain wordsIn rats with hypoxia-ischemia, carnosine improved memory.

    Peptide
    L-carnosine
    Outcome
    IncreaseMemory
    Study

    ratn: not reported in source

    Neonatal hypoxia-ischemia
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, carnosine also improved the spatial learning and memory abilities of rats declined due to hypoxia-ischemia.
    2 context sentences
    Summary · context
    Hypoxia-ischemia was induced in rats on postnatal day 7 (P7).
    Summary · context
    Carnosine (250 mg/kg) was administered intraperitoneally, 30 min prior to hypoxia-ischemia induction.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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