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Study · Animal study (in vivo) · syrian hamster · 2011

5 results

Peripheral kisspeptin reverses short photoperiod-induced gonadal regression in Syrian hamsters by promoting GNRH release.

Ansel L, Bentsen AH, Ancel C, Bolborea M, Klosen P, Mikkelsen JD, Simonneaux V

Reproduction (Cambridge, England)13 Jun 2011Cited by 38 (Europe PMC)

PMID21670127 (opens in a new tab)DOI10.1530/rep-10-0313 (opens in a new tab)PepBankPUB-21670127
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In short-day Syrian hamsters, two daily i.p. injections of Kp54 reactivated testicular activity.

    In plain wordsIn hamsters kept in short days, two daily injections of Kp54 restored testicular activity.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseTesticular activity with two daily i.p. injections
    Study

    Syrian hamstern: not reported in source

    photo-inhibited hamsters kept in short days
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitonealAs given in this study (Syrian hamster).

    Source sentences

    Summary
    Testicular activity of hamsters kept in SD was reactivated by two daily i.p. injections of Kp54
    1 context sentence
    Summary · context
    The aim of this study was to determine if and how peripheral administration of Kp54 could restore gonadal function in photo-inhibited hamsters.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In short-day Syrian hamsters, chronic subcutaneous delivery of Kp54 via mini-pumps did not reactivate testicular activity.

    In plain wordsIn hamsters kept in short days, continuous Kp54 delivery by mini-pump did not restore testicular activity.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeTesticular activity with chronic subcutaneous delivery via mini-pumps
    Study

    Syrian hamstern: not reported in source

    photo-inhibited hamsters kept in short days
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous mini-pump · chronicAs given in this study (Syrian hamster).

    Source sentences

    Summary
    Testicular activity of hamsters kept in SD was reactivated by two daily i.p. injections of Kp54 but not by chronic subcutaneous delivery of the same peptide via mini-pumps.
    1 context sentence
    Summary · context
    The aim of this study was to determine if and how peripheral administration of Kp54 could restore gonadal function in photo-inhibited hamsters.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In short-day Syrian hamsters, acute i.p. injection of Kp54 induced FOS expression in many GNRH neurons and pituitary gonadotrophs.

    In plain wordsIn hamsters kept in short days, one Kp54 injection switched on FOS in many GNRH neurons and pituitary cells.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseFOS expression in GNRH neurons and pituitary gonadotrophs after acute i.p. injection
    Study

    Syrian hamstern: not reported in source

    photo-inhibited hamsters kept in short days
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitoneal · acuteAs given in this study (Syrian hamster).

    Source sentences

    Summary
    Acute i.p. injection of Kp54-induced FOS (c-Fos) expression in a large number of GNRH neurons and pituitary gonadotrophs
    1 context sentence
    Summary · context
    The aim of this study was to determine if and how peripheral administration of Kp54 could restore gonadal function in photo-inhibited hamsters.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In short-day Syrian hamsters, acute i.p. injection of Kp54 strongly increased circulating testosterone.

    In plain wordsIn hamsters kept in short days, one Kp54 injection strongly raised blood testosterone.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseCirculating testosterone after acute i.p. injection
    Study

    Syrian hamstern: not reported in source

    photo-inhibited hamsters kept in short days
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitoneal · acuteAs given in this study (Syrian hamster).

    Source sentences

    Summary
    together with a strong increase in circulating testosterone.
    1 context sentence
    Summary · context
    The aim of this study was to determine if and how peripheral administration of Kp54 could restore gonadal function in photo-inhibited hamsters.

Studies that did not test the peptide alone1

In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-54 (metastin).

  1. 05AnimalNot a test of Kisspeptin-54 (metastin) aloneAnimal study (in vivo)Mechanism

    In short-day Syrian hamsters, preadministration of the GNRH receptor antagonist acyline inhibited the activation of pituitary cells by Kp.

    In plain wordsIn hamsters kept in short days, blocking the GNRH receptor with acyline stopped Kp from activating pituitary cells.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreasePituitary cell activation by Kp with acyline preadministration
    Study

    Syrian hamstern: not reported in source

    photo-inhibited hamsters kept in short days
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    The activation of pituitary cells by Kp was inhibited by preadministration of the GNRH receptor antagonist acyline.
    1 context sentence
    Summary · context
    The aim of this study was to determine if and how peripheral administration of Kp54 could restore gonadal function in photo-inhibited hamsters.

    In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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