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Study · Animal study (in vivo) · mouse · 2011

2 results

De novo cardiomyocytes from within the activated adult heart after injury.

Smart N, Bollini S, Dubé KN, Vieira JM, Zhou B, Davidson S, Yellon D, Riegler J, Price AN, Lythgoe MF, Pu WT, Riley PR

Nature8 Jun 2011Cited by 492 (Europe PMC)

PMID21654746 (opens in a new tab)PMCIDPMC3696525 (opens in a new tab)DOI10.1038/nature10188 (opens in a new tab)PepBankPUB-21654746
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, priming with thymosin beta‑4 led to re-expression of the embryonic epicardial gene Wt1 in activated adult heart progenitor cells after injury.

    In plain wordsIn mice, thymosin beta‑4 priming switched the embryonic gene Wt1 back on in progenitor cells of the injured adult heart.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseWt1 re-expression in adult epicardial progenitors after thymosin beta-4 priming
    Study

    mousen: not reported in source

    adult mouse heart after myocardial infarction
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We reveal a novel genetic label of the activated adult progenitors via re-expression of a key embryonic epicardial gene, Wilm's tumour 1 (Wt1), through priming by thymosin β4, a peptide previously shown to restore vascular potential to adult epicardium-derived progenitor cells with injury.
    1 context sentence
    Summary · context
    Here we demonstrate in mice that the adult heart contains a resident stem or progenitor cell population, which has the potential to contribute bona fide terminally differentiated cardiomyocytes after myocardial infarction.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice after myocardial infarction, embryonic reprogramming of adult epicardial progenitors, primed by thymosin beta‑4, mobilized them and gave rise to de novo cardiomyocytes.

    In plain wordsIn mice, priming of progenitor cells in the injured adult heart with thymosin beta‑4 was followed by the formation of new heart muscle cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseDe novo cardiomyocytes from mobilized epicardial progenitors after thymosin beta-4 priming
    Study

    mousen: not reported in source

    adult mouse heart after myocardial infarction
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cumulative evidence indicates an epicardial origin of the progenitor population, and embryonic reprogramming results in the mobilization of this population and concomitant differentiation to give rise to de novo cardiomyocytes.
    1 context sentence
    Summary · context
    We reveal a novel genetic label of the activated adult progenitors via re-expression of a key embryonic epicardial gene, Wilm's tumour 1 (Wt1), through priming by thymosin β4, a peptide previously shown to restore vascular potential to adult epicardium-derived progenitor cells with injury.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

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