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Study · Non-randomized trial · n = 6 · 2011

7 results

Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.

George JT, Veldhuis JD, Roseweir AK, Newton CL, Faccenda E, Millar RP, Anderson RA

The Journal of clinical endocrinology and metabolism1 Jun 2011Cited by 127 (Europe PMC)

PMID21632807 (opens in a new tab)PMCIDPMC3380939 (opens in a new tab)DOI10.1210/jc.2011-0089 (opens in a new tab)PepBankPUB-21632807
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy men, intravenous bolus kisspeptin‑10 caused a rapid, dose-dependent rise in serum LH, with maximal stimulation at 1 μg/kg.

    In plain wordsIn healthy men, kisspeptin‑10 injections raised blood LH, most at 1 μg/kg.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum LH after bolus kisspeptin-10 at 1 μg/kg
    Study

    n = 6

    Comparator
    Baseline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 μg/kg · intravenousAs given in this study (human).

    Measurements

    LH
    4.1 IU/liter
    baseline
    LH
    12.4 IU/liter
    30 min after 1 μg/kg

    Source sentences

    Summary
    Intravenous bolus kisspeptin-10 resulted in a rapid and dose-dependent rise in serum LH concentration, with maximal stimulation at 1 μg/kg (4.1 ± 0.4 to 12.4 ± 1.7 IU/liter at 30 min, P < 0.001, n = 6).
    1 context sentence
    Summary · context
    The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 μg/kg) and vehicle to healthy men.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy men, a 22.5 h infusion of kisspeptin‑10 at 4 μg/kg/h increased mean LH.

    In plain wordsIn healthy men, a 22.5 hour kisspeptin‑10 infusion raised average blood LH.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMean LH during 22.5 h kisspeptin-10 infusion
    Study

    n = 4

    Comparator
    Baseline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    4 μg/kg/h · intravenous · 22.5 hAs given in this study (human).

    Measurements

    Mean LH
    5.4 IU/liter
    baseline
    Mean LH
    20.8 IU/liter
    4 μg/kg/h infusion

    Source sentences

    Summary
    Infusion of kisspeptin-10 at 4 μg/kg · h for 22.5 h elicited an increase in LH from a mean of 5.4 ± 0.7 to 20.8 ± 4.9 IU/liter (n = 4; P < 0.05)
    2 context sentences
    Summary · context
    Effects on LH pulse frequency and size were determined by deconvolution analysis during infusion of kisspeptin-10 for up to 22.5 h.
    Summary · context
    The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 μg/kg) and vehicle to healthy men.
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy men, a 22.5 h infusion of kisspeptin‑10 at 4 μg/kg/h increased serum testosterone.

    In plain wordsIn healthy men, a 22.5 hour kisspeptin‑10 infusion raised blood testosterone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum testosterone during 22.5 h kisspeptin-10 infusion
    Study

    n = 4

    Comparator
    Baseline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    4 μg/kg/h · intravenous · 22.5 hAs given in this study (human).

    Measurements

    Testosterone
    16.6 nmol/liter
    baseline
    Testosterone
    24 nmol/liter
    4 μg/kg/h infusion

    Source sentences

    Summary
    serum testosterone increased from 16.6 ± 2.4 to 24.0 ± 2.5 nmol/liter (P < 0.001).
    2 context sentences
    Summary · context
    Effects on LH pulse frequency and size were determined by deconvolution analysis during infusion of kisspeptin-10 for up to 22.5 h.
    Summary · context
    The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 μg/kg) and vehicle to healthy men.
  4. 04HumanNon-randomized trialEfficacy outcome

    In healthy men, kisspeptin‑10 infusion at 1.5 μg/kg/h increased mean LH.

    In plain wordsIn healthy men, a lower dose kisspeptin‑10 infusion raised average blood LH.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMean LH during lower dose kisspeptin-10 infusion
    Study

    n = 4

    Comparator
    Baseline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1.5 μg/kg/h · intravenousAs given in this study (human).

    Measurements

    Mean LH
    5.2 IU/liter
    baseline
    Mean LH
    14.1 IU/liter
    1.5 μg/kg/h infusion

    Source sentences

    Summary
    a lower dose infusion of kisspeptin-10 (1.5 μg/kg · h) increased mean LH from 5.2 ± 0.8 to 14.1 ± 1.7 IU/liter (n = 4; P < 0.01)
    2 context sentences
    Summary · context
    Effects on LH pulse frequency and size were determined by deconvolution analysis during infusion of kisspeptin-10 for up to 22.5 h.
    Summary · context
    The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 μg/kg) and vehicle to healthy men.
  5. 05HumanNon-randomized trialEfficacy outcome

    In healthy men, kisspeptin‑10 infusion at 1.5 μg/kg/h increased LH pulse frequency.

    In plain wordsIn healthy men, a lower dose kisspeptin‑10 infusion made LH pulses more frequent.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH pulse frequency during lower dose infusion
    Study

    n = 4

    Comparator
    Baseline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1.5 μg/kg/h · intravenousAs given in this study (human).

    Measurements

    LH pulse frequency
    0.7 pulses/h
    baseline
    LH pulse frequency
    1 pulses/h
    1.5 μg/kg/h infusion

    Source sentences

    Summary
    increased LH pulse frequency from 0.7 ± 0.1 to 1.0 ± 0.2 pulses/h (P < 0.05)
    2 context sentences
    Summary · context
    Effects on LH pulse frequency and size were determined by deconvolution analysis during infusion of kisspeptin-10 for up to 22.5 h.
    Summary · context
    The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 μg/kg) and vehicle to healthy men.
  6. 06HumanNon-randomized trialEfficacy outcome

    In healthy men, kisspeptin‑10 infusion at 1.5 μg/kg/h increased LH secretory burst mass.

    In plain wordsIn healthy men, a lower dose kisspeptin‑10 infusion increased the size of each LH release burst.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH secretory burst mass during lower dose infusion
    Study

    n = 4

    Comparator
    Baseline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1.5 μg/kg/h · intravenousAs given in this study (human).

    Measurements

    LH secretory burst mass
    3.9 IU/liter
    baseline
    LH secretory burst mass
    12.8 IU/liter
    1.5 μg/kg/h infusion

    Source sentences

    Summary
    secretory burst mass from 3.9 ± 0.4 to 12.8 ± 2.6 IU/liter (P < 0.05).
    2 context sentences
    Summary · context
    Effects on LH pulse frequency and size were determined by deconvolution analysis during infusion of kisspeptin-10 for up to 22.5 h.
    Summary · context
    The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 μg/kg) and vehicle to healthy men.
  7. 07HumanNon-randomized trialEfficacy outcome

    In healthy men, a 3 μg/kg kisspeptin‑10 bolus elicited a smaller LH response than a 1 μg/kg bolus.

    In plain wordsIn healthy men, a 3 μg/kg kisspeptin‑10 injection raised LH less than a 1 μg/kg injection.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseLH response to 3 μg/kg vs 1 μg/kg bolus
    Study

    n: not reported in source

    Comparator
    1 μg/kg bolus
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    3 μg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Administration of 3 μg/kg elicited a reduced response vs. 1 μg/kg (P < 0.05).
    1 context sentence
    Summary · context
    The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 μg/kg) and vehicle to healthy men.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 3NCT03315325

Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in Men

Quaid-e-Azam Universityn = 158 Aug 2014 to 5 Mar 2015

Sterility, Reproductive

Trial pageClinicalTrials.govUpdated 23 Oct 2017

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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