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Study · Animal study (in vivo) · rat · 2011

3 results

Quantitative iTRAQ analysis of retinal ganglion cell degeneration after optic nerve crush.

Magharious M, D'Onofrio PM, Hollander A, Zhu P, Chen J, Koeberle PD

Journal of proteome research29 Jun 2011Cited by 35 (Europe PMC)

PMID21627321 (opens in a new tab)DOI10.1021/pr2004055 (opens in a new tab)PepBankPUB-21627321
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with optic nerve crush, intraocular injections of thymosin beta‑4 significantly increased retinal ganglion cell survival by about 3-fold compared with controls.

    In plain wordsIn rats with optic nerve injury, thymosin beta‑4 injected into the eye raised the survival of retinal nerve cells compared with controls.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseRetinal ganglion cell survival after optic nerve injury
    Study

    ratn: not reported in source

    Optic nerve crush
    Comparator
    Controls
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intraocularAs given in this study (rat).

    Source sentences

    Summary
    Intraocular injections of Thymosin-β4 significantly increased RGC survival by ∼ 3-fold compared to controls and enhanced axon regeneration after crush, demonstrating therapeutic potential for CNS insults.
    2 context sentences
    Summary · context
    We examined the effect of exogenous Thymosin-β4 administration on RGC death after optic nerve injury.
    Summary · context
    Here, we performed a large scale iTRAQ proteomic study to identify and quantify proteins of the rat retina at 1, 3, 4, 7, 14, and 21 days after optic nerve crush.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with optic nerve crush, intraocular injections of thymosin beta‑4 enhanced axon regeneration after crush.

    In plain wordsIn rats with optic nerve injury, thymosin beta‑4 injected into the eye improved nerve fiber regrowth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAxon regeneration after optic nerve crush
    Study

    ratn: not reported in source

    Optic nerve crush
    Comparator
    Controls
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated · intraocularAs given in this study (rat).

    Source sentences

    Summary
    Intraocular injections of Thymosin-β4 significantly increased RGC survival by ∼ 3-fold compared to controls and enhanced axon regeneration after crush, demonstrating therapeutic potential for CNS insults.
    2 context sentences
    Summary · context
    We examined the effect of exogenous Thymosin-β4 administration on RGC death after optic nerve injury.
    Summary · context
    Here, we performed a large scale iTRAQ proteomic study to identify and quantify proteins of the rat retina at 1, 3, 4, 7, 14, and 21 days after optic nerve crush.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In rats after optic nerve crush, retinal levels of the body's own thymosin beta‑4 were upregulated early, at 3 days.

    In plain wordsIn rats with optic nerve injury, the body's own thymosin beta‑4 in the retina rose early, at 3 days.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseRetinal Tβ4 protein after optic nerve crush
    Study

    ratn: not reported in source

    Optic nerve crush
    Outcome group
    Neuroprotection · Eye

    Source sentences

    Summary
    Among the differentially expressed proteins, Thymosin-β4 showed an early upregulation at 3 days, the time-point that immediately precedes the induction of RGC apoptosis after injury.
    1 context sentence
    Summary · context
    Here, we performed a large scale iTRAQ proteomic study to identify and quantify proteins of the rat retina at 1, 3, 4, 7, 14, and 21 days after optic nerve crush.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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