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Study · Not a test of the peptide alone · 2011

7 results

Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway.

Tang MC, Chan LC, Yeh YC, Chen CY, Chou TY, Wang WS, Su Y

Cancer letters28 May 2011Cited by 42 (Europe PMC)

PMID21621326 (opens in a new tab)DOI10.1016/j.canlet.2011.05.001 (opens in a new tab)PepBankPUB-21621326
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In SW480 colon cancer cells, Tβ4 overexpression was associated with higher Rac1 activity.

    In plain wordsIn SW480 colon cancer cells with raised Tβ4 gene activity, Rac1 activity was higher.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseRac1 activity in Tβ4-overexpressing cells
    Study

    humann: not reported in source

    SW480 colon cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ(4)-overexpressing SW480 cells.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In SW480 colon cancer cells, Tβ4 overexpression was associated with higher expression of IQGAP1.

    In plain wordsIn SW480 colon cancer cells with raised Tβ4 gene activity, IQGAP1 levels were higher.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseIQGAP1 expression in Tβ4-overexpressing cells
    Study

    humann: not reported in source

    SW480 colon cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ(4)-overexpressing SW480 cells.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In SW480 colon cancer cells, Tβ4 overexpression was associated with higher expression of ILK.

    In plain wordsIn SW480 colon cancer cells with raised Tβ4 gene activity, ILK levels were higher.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseILK expression in Tβ4-overexpressing cells
    Study

    humann: not reported in source

    SW480 colon cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ(4)-overexpressing SW480 cells.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    In SW480 colon cancer cells, Tβ4-overexpressing cells were highly migrated.

    In plain wordsIn SW480 colon cancer cells with raised Tβ4 gene activity, the cells migrated more.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMigration of Tβ4-overexpressing cells
    Study

    humann: not reported in source

    SW480 colon cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ(4)-overexpressing SW480 cells.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In SW480 colon cancer cells, knockdown of Tβ4 reduced ILK protein levels.

    In plain wordsIn lab-grown colon cancer cells, removing thymosin beta‑4 lowered ILK protein.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseILK protein level after Tβ4 knockdown
    Study

    humann: not reported in source

    SW480 colon cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In addition, IQGAP1 formed a complex with ILK and knockdown of Tβ(4) simultaneously reduced ILK and IQGAP1 protein levels as well as their migration ability.
    1 context sentence
    Summary · context
    We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ(4)-overexpressing SW480 cells.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  6. 06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In SW480 colon cancer cells, knockdown of Tβ4 reduced IQGAP1 protein levels.

    In plain wordsIn lab-grown colon cancer cells, removing thymosin beta‑4 lowered IQGAP1 protein.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseIQGAP1 protein level after Tβ4 knockdown
    Study

    humann: not reported in source

    SW480 colon cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In addition, IQGAP1 formed a complex with ILK and knockdown of Tβ(4) simultaneously reduced ILK and IQGAP1 protein levels as well as their migration ability.
    1 context sentence
    Summary · context
    We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ(4)-overexpressing SW480 cells.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  7. 07LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    In SW480 colon cancer cells, knockdown of Tβ4 reduced migration ability.

    In plain wordsIn lab-grown colon cancer cells, removing thymosin beta‑4 reduced cell migration.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCell migration after Tβ4 knockdown
    Study

    humann: not reported in source

    SW480 colon cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In addition, IQGAP1 formed a complex with ILK and knockdown of Tβ(4) simultaneously reduced ILK and IQGAP1 protein levels as well as their migration ability.
    1 context sentence
    Summary · context
    We demonstrated higher Rac1 activities and expression levels of IQGAP1 and ILK in highly migrated Tβ(4)-overexpressing SW480 cells.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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