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Study · Animal study (in vivo) · rat · 2011

8 results

Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury.

Szeto HH, Liu S, Soong Y, Wu D, Darrah SF, Cheng FY, Zhao Z, Ganger M, Tow CY, Seshan SV

Journal of the American Society of Nephrology : JASN5 May 2011Cited by 263 (Europe PMC)

PMID21546574 (opens in a new tab)PMCIDPMC3103724 (opens in a new tab)DOI10.1681/asn.2010080808 (opens in a new tab)PepBankPUB-21546574
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In a rat model of renal ischemia-reperfusion, SS‑31 protected mitochondrial structure and respiration during early reperfusion.

    In plain wordsIn rats with kidney injury from interrupted blood flow, SS‑31 protected the structure and function of mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial structure and respiration during early reperfusion
    Study

    ratn: not reported in source

    Rat ischemia-reperfusion kidney injury
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, in a rat model of ischemia-reperfusion (IR) injury, treatment with SS-31 protected mitochondrial structure and respiration during early reperfusion
  2. 02AnimalAnimal study (in vivo)Mechanism

    In a rat model of renal ischemia-reperfusion, SS‑31 accelerated recovery of ATP.

    In plain wordsIn rats with kidney injury from interrupted blood flow, SS‑31 sped up the recovery of cell energy (ATP).

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseATP recovery
    Study

    ratn: not reported in source

    Rat ischemia-reperfusion kidney injury
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, in a rat model of ischemia-reperfusion (IR) injury, treatment with SS-31 protected mitochondrial structure and respiration during early reperfusion, accelerated recovery of ATP
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In a rat model of renal ischemia-reperfusion, SS‑31 reduced apoptosis and necrosis of tubular cells.

    In plain wordsIn rats with kidney injury from interrupted blood flow, SS‑31 reduced the death of kidney tubule cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTubular cell apoptosis and necrosis
    Study

    ratn: not reported in source

    Rat ischemia-reperfusion kidney injury
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, in a rat model of ischemia-reperfusion (IR) injury, treatment with SS-31 protected mitochondrial structure and respiration during early reperfusion, accelerated recovery of ATP, reduced apoptosis and necrosis of tubular cells
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In a rat model of renal ischemia-reperfusion, SS‑31 abrogated tubular dysfunction.

    In plain wordsIn rats with kidney injury from interrupted blood flow, SS‑31 prevented kidney tubule dysfunction.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTubular dysfunction
    Study

    ratn: not reported in source

    Rat ischemia-reperfusion kidney injury
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, in a rat model of ischemia-reperfusion (IR) injury, treatment with SS-31 protected mitochondrial structure and respiration during early reperfusion, accelerated recovery of ATP, reduced apoptosis and necrosis of tubular cells, and abrogated tubular dysfunction.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In a rat model of renal ischemia-reperfusion, SS‑31 reduced medullary vascular congestion.

    In plain wordsIn rats with kidney injury from interrupted blood flow, SS‑31 reduced blood pooling in the inner kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMedullary vascular congestion
    Study

    ratn: not reported in source

    Rat ischemia-reperfusion kidney injury
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, SS-31 reduced medullary vascular congestion
    1 context sentence
    Summary · context
    Here, in a rat model of ischemia-reperfusion (IR) injury
  6. 06AnimalAnimal study (in vivo)Mechanism

    In a rat model of renal ischemia-reperfusion, SS‑31 decreased IR-mediated oxidative stress.

    In plain wordsIn rats with kidney injury from interrupted blood flow, SS‑31 lowered oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIR-mediated oxidative stress
    Study

    ratn: not reported in source

    Rat ischemia-reperfusion kidney injury
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, SS-31 reduced medullary vascular congestion, decreased IR-mediated oxidative stress
    1 context sentence
    Summary · context
    Here, in a rat model of ischemia-reperfusion (IR) injury
  7. 07AnimalAnimal study (in vivo)Mechanism

    In a rat model of renal ischemia-reperfusion, SS‑31 decreased the inflammatory response.

    In plain wordsIn rats with kidney injury from interrupted blood flow, SS‑31 lowered the inflammatory response.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseInflammatory response
    Study

    ratn: not reported in source

    Rat ischemia-reperfusion kidney injury
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, SS-31 reduced medullary vascular congestion, decreased IR-mediated oxidative stress and the inflammatory response
    1 context sentence
    Summary · context
    Here, in a rat model of ischemia-reperfusion (IR) injury
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In a rat model of renal ischemia-reperfusion, SS‑31 accelerated the proliferation of surviving tubular cells as early as 1 day after reperfusion.

    In plain wordsIn rats with kidney injury from interrupted blood flow, SS‑31 sped up the regrowth of surviving kidney tubule cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseProliferation of surviving tubular cells
    Study

    ratn: not reported in source

    Rat ischemia-reperfusion kidney injury
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · 1 day after reperfusionAs given in this study (rat).

    Source sentences

    Summary
    In addition, SS-31 reduced medullary vascular congestion, decreased IR-mediated oxidative stress and the inflammatory response, and accelerated the proliferation of surviving tubular cells as early as 1 day after reperfusion.
    1 context sentence
    Summary · context
    Here, in a rat model of ischemia-reperfusion (IR) injury

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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