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Study · In vitro (cells) · 2011

10 results

Thymosin-β4 (Tβ4) blunts PDGF-dependent phosphorylation and binding of AKT to actin in hepatic stellate cells.

Reyes-Gordillo K, Shah R, Popratiloff A, Fu S, Hindle A, Brody F, Rojkind M

The American journal of pathology1 May 2011Cited by 38 (Europe PMC)

PMID21514425 (opens in a new tab)PMCIDPMC3081167 (opens in a new tab)DOI10.1016/j.ajpath.2011.01.025 (opens in a new tab)PepBankPUB-21514425
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human hepatic stellate cells, thymosin beta‑4 inhibited cell proliferation.

    In plain wordsIn lab-grown human liver stellate cells, thymosin beta‑4 reduced cell growth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseHSC proliferation
    Study

    humann: not reported in source

    Early-passage human hepatic stellate cells (HSC)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Using early passages of human HSC, we showed that Tβ4 inhibited cell proliferation and migration and prevented the expression of PDGF-β receptor (PDGF-βr), α-smooth muscle actin and α1(I) collagen mRNAs.
    1 context sentence
    Summary · context
    In this communication, we investigated whether thymosin-β4 (Tβ4), a chemokine expressed by HSC could prevent PDGF-BB-mediated proliferation and migration of cultured HSC.
  2. 02LabIn vitro (cells)Activity measurement

    In human hepatic stellate cells, thymosin beta‑4 inhibited cell migration.

    In plain wordsIn lab-grown human liver stellate cells, thymosin beta‑4 reduced cell movement.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseHSC migration
    Study

    humann: not reported in source

    Early-passage human hepatic stellate cells (HSC)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Using early passages of human HSC, we showed that Tβ4 inhibited cell proliferation and migration and prevented the expression of PDGF-β receptor (PDGF-βr), α-smooth muscle actin and α1(I) collagen mRNAs.
    1 context sentence
    Summary · context
    In this communication, we investigated whether thymosin-β4 (Tβ4), a chemokine expressed by HSC could prevent PDGF-BB-mediated proliferation and migration of cultured HSC.
  3. 03LabIn vitro (cells)Mechanism

    In human hepatic stellate cells, thymosin beta‑4 prevented expression of the PDGF-beta receptor.

    In plain wordsIn lab-grown human liver stellate cells, thymosin beta‑4 prevented the appearance of the PDGF-beta receptor.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreasePDGF-beta receptor expression
    Study

    humann: not reported in source

    Early-passage human hepatic stellate cells (HSC)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Using early passages of human HSC, we showed that Tβ4 inhibited cell proliferation and migration and prevented the expression of PDGF-β receptor (PDGF-βr), α-smooth muscle actin and α1(I) collagen mRNAs.
    1 context sentence
    Summary · context
    In this communication, we investigated whether thymosin-β4 (Tβ4), a chemokine expressed by HSC could prevent PDGF-BB-mediated proliferation and migration of cultured HSC.
  4. 04LabIn vitro (cells)Mechanism

    In human hepatic stellate cells, thymosin beta‑4 prevented expression of alpha-smooth muscle actin mRNA.

    In plain wordsIn lab-grown human liver stellate cells, thymosin beta‑4 prevented a marker of activated cells from appearing.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseAlpha-smooth muscle actin mRNA
    Study

    humann: not reported in source

    Early-passage human hepatic stellate cells (HSC)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Using early passages of human HSC, we showed that Tβ4 inhibited cell proliferation and migration and prevented the expression of PDGF-β receptor (PDGF-βr), α-smooth muscle actin and α1(I) collagen mRNAs.
    1 context sentence
    Summary · context
    In this communication, we investigated whether thymosin-β4 (Tβ4), a chemokine expressed by HSC could prevent PDGF-BB-mediated proliferation and migration of cultured HSC.
  5. 05LabIn vitro (cells)Mechanism

    In human hepatic stellate cells, thymosin beta‑4 prevented expression of alpha1(I) collagen mRNA.

    In plain wordsIn lab-grown human liver stellate cells, thymosin beta‑4 prevented a collagen gene signal from appearing.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseAlpha1(I) collagen mRNA
    Study

    humann: not reported in source

    Early-passage human hepatic stellate cells (HSC)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Using early passages of human HSC, we showed that Tβ4 inhibited cell proliferation and migration and prevented the expression of PDGF-β receptor (PDGF-βr), α-smooth muscle actin and α1(I) collagen mRNAs.
    1 context sentence
    Summary · context
    In this communication, we investigated whether thymosin-β4 (Tβ4), a chemokine expressed by HSC could prevent PDGF-BB-mediated proliferation and migration of cultured HSC.
  6. 06LabIn vitro (cells)Mechanism

    In human hepatic stellate cells, thymosin beta‑4 inhibited the reappearance of the PDGF-beta receptor after PDGF-BB-dependent degradation.

    In plain wordsIn lab-grown human liver stellate cells, thymosin beta‑4 stopped the PDGF-beta receptor from coming back after PDGF-BB removed it.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreasePDGF-beta receptor reappearance after PDGF-BB degradation
    Study

    humann: not reported in source

    Early-passage human hepatic stellate cells (HSC)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 also inhibited the reappearance of PDGF-βr after its PDGF-BB-dependent degradation.
    1 context sentence
    Summary · context
    In this communication, we investigated whether thymosin-β4 (Tβ4), a chemokine expressed by HSC could prevent PDGF-BB-mediated proliferation and migration of cultured HSC.
  7. 07LabIn vitro (cells)Mechanism

    In human hepatic stellate cells, the PDGF-dependent events blocked by thymosin beta‑4 were associated with inhibition of AKT phosphorylation at T308 and S473.

    In plain wordsIn lab-grown human liver stellate cells, thymosin beta‑4 was linked to less AKT activation by phosphorylation.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseAKT phosphorylation at T308 and S473
    Study

    humann: not reported in source

    Early-passage human hepatic stellate cells (HSC)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These PDGF-dependent events were associated with the inhibition of AKT phosphorylation at both T308 and S473 amino acid residues.
    2 context sentences
    Title · context
    Thymosin-β4 (Tβ4) blunts PDGF-dependent phosphorylation and binding of AKT to actin in hepatic stellate cells.
    Summary · context
    In this communication, we investigated whether thymosin-β4 (Tβ4), a chemokine expressed by HSC could prevent PDGF-BB-mediated proliferation and migration of cultured HSC.
  8. 08LabIn vitro (cells)Mechanism

    In human hepatic stellate cells, the lack of AKT phosphorylation with thymosin beta‑4 was not due to inhibition of PDGF-beta receptor phosphorylation or activation of PI3K, PDK1 or mTOR.

    In plain wordsIn lab-grown human liver stellate cells, thymosin beta‑4 did not reduce AKT activation by blocking these upstream steps.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changePDGF-beta receptor phosphorylation, PI3K, PDK1 and mTOR activation
    Study

    humann: not reported in source

    Early-passage human hepatic stellate cells (HSC)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The lack of AKT phosphorylation was not due to the inhibition of PDGF-βr phosphorylation, the activation of phosphoinositide 3-kinase (PI3K), pyruvate dehydrogenase kinase isozyme 1 (PDK1), and mammalian target of rapamycin (mTOR).
    2 context sentences
    Title · context
    Thymosin-β4 (Tβ4) blunts PDGF-dependent phosphorylation and binding of AKT to actin in hepatic stellate cells.
    Summary · context
    In this communication, we investigated whether thymosin-β4 (Tβ4), a chemokine expressed by HSC could prevent PDGF-BB-mediated proliferation and migration of cultured HSC.
  9. 09LabIn vitro (cells)Mechanism

    In human hepatic stellate cells, thymosin beta‑4 prevented the PDGF-BB-induced binding of AKT to actin.

    In plain wordsIn lab-grown human liver stellate cells, thymosin beta‑4 stopped AKT from binding to actin after PDGF-BB.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreasePDGF-BB-induced AKT binding to actin
    Study

    humann: not reported in source

    Early-passage human hepatic stellate cells (HSC)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that PDGF-BB induced AKT binding to actin, and that Tβ4 prevented this effect.
    1 context sentence
    Summary · context
    In this communication, we investigated whether thymosin-β4 (Tβ4), a chemokine expressed by HSC could prevent PDGF-BB-mediated proliferation and migration of cultured HSC.
  10. 10LabIn vitro (cells)Mechanism

    In freshly isolated hepatic stellate cells in culture, thymosin beta‑4 prevented activation.

    In plain wordsIn lab-grown liver stellate cells freshly isolated from tissue, thymosin beta‑4 prevented the cells from becoming activated.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseActivation of freshly isolated HSC in culture
    Study

    n: not reported in source

    Freshly isolated HSC cultured in DMEM with 10% fetal bovine serum
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 also prevented the activation of freshly isolated HSC cultured in the presence of Dulbecco's modified Eagle's medium or Dulbecco's minimal essential medium containing 10% fetal bovine serum.
    1 context sentence
    Summary · context
    In this communication, we investigated whether thymosin-β4 (Tβ4), a chemokine expressed by HSC could prevent PDGF-BB-mediated proliferation and migration of cultured HSC.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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