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Study · Non-randomized trial · n = 19 · 2011

7 results

Oral lyophylizate formulation of desmopressin: superior pharmacodynamics compared to tablet due to low food interaction.

De Guchtenaere A, Van Herzeele C, Raes A, Dehoorne J, Hoebeke P, Van Laecke E, Vande Walle J

The Journal of urology21 Apr 2011Cited by 34 (Europe PMC)

PMID21511277 (opens in a new tab)DOI10.1016/j.juro.2011.02.039 (opens in a new tab)PepBankPUB-21511277
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In children, desmopressin melt produced lower early diuresis rates than tablets in more than 25% of patients.

    In plain wordsIn children, desmopressin melt produced lower early urine output than tablets in more than 25% of patients.

    Peptide
    Desmopressin
    Outcome
    DecreaseEarly diuresis rate
    Study

    n = 19

    Comparator
    Desmopressin tablet with a standardized meal
    Outcome group
    Urine Production · Kidney and urinary
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Measurements

    Patients with higher diuresis rate on tablet than melt
    > 25%
    early response phase

    Source sentences

    Summary
    In the early response phase more than 25% of patients had a higher diuresis rate with tablet vs melt formulation, reaching statistical significance in the plateau phase (urine collected at hours 3 to 5, p <0.02) and in duration of action (urine collected at hours 5 to 8, p <0.005).
    2 context sentences
    Summary · context
    After achieving maximal diluting capacity a standardized meal was administered, followed by desmopressin tablet (t test) or melt (M-test).
    Summary · context
    Paired data from 4 girls and 15 boys with a mean age of 12.1 years were obtained.
  2. 02HumanNon-randomized trialActivity measurement

    In children, diuresis rates were lower with desmopressin melt than tablets during hours 3 to 5 (p <0.02).

    In plain wordsIn children, desmopressin melt reduced urine output more than tablets during hours 3 to 5.

    Peptide
    Desmopressin
    Outcome
    DecreasePlateau diuresis rate
    Study

    n = 19

    Comparator
    Desmopressin tablet with a standardized meal
    Outcome group
    Urine Production · Kidney and urinary
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Measurements

    P value
    < 0.02
    diuresis rate, plateau phase (hours 3 to 5), tablet vs melt

    Source sentences

    Summary
    In the early response phase more than 25% of patients had a higher diuresis rate with tablet vs melt formulation, reaching statistical significance in the plateau phase (urine collected at hours 3 to 5, p <0.02) and in duration of action (urine collected at hours 5 to 8, p <0.005).
    2 context sentences
    Summary · context
    After achieving maximal diluting capacity a standardized meal was administered, followed by desmopressin tablet (t test) or melt (M-test).
    Summary · context
    Paired data from 4 girls and 15 boys with a mean age of 12.1 years were obtained.
  3. 03HumanNon-randomized trialActivity measurement

    In children, diuresis rates were lower with desmopressin melt than tablets during hours 5 to 8 (p <0.005).

    In plain wordsIn children, desmopressin melt reduced urine output more than tablets during hours 5 to 8.

    Peptide
    Desmopressin
    Outcome
    DecreaseLate diuresis rate
    Study

    n = 19

    Comparator
    Desmopressin tablet with a standardized meal
    Outcome group
    Urine Production · Kidney and urinary
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Measurements

    P value
    < 0.005
    diuresis rate, duration of action (hours 5 to 8), tablet vs melt

    Source sentences

    Summary
    In the early response phase more than 25% of patients had a higher diuresis rate with tablet vs melt formulation, reaching statistical significance in the plateau phase (urine collected at hours 3 to 5, p <0.02) and in duration of action (urine collected at hours 5 to 8, p <0.005).
    2 context sentences
    Summary · context
    After achieving maximal diluting capacity a standardized meal was administered, followed by desmopressin tablet (t test) or melt (M-test).
    Summary · context
    Paired data from 4 girls and 15 boys with a mean age of 12.1 years were obtained.
  4. 04HumanNon-randomized trialActivity measurement

    In children, desmopressin melt showed smaller standard deviations in diuresis rate than tablets.

    In plain wordsIn children, urine output varied less with desmopressin melt than tablets.

    Peptide
    Desmopressin
    Outcome
    DecreaseDiuresis rate variability
    Study

    n = 19

    Comparator
    Desmopressin tablet with a standardized meal
    Outcome group
    Urine Production · Kidney and urinary
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Source sentences

    Summary
    For desmopressin melt smaller standard deviations in diuresis rate were remarkable.
    2 context sentences
    Summary · context
    After achieving maximal diluting capacity a standardized meal was administered, followed by desmopressin tablet (t test) or melt (M-test).
    Summary · context
    Paired data from 4 girls and 15 boys with a mean age of 12.1 years were obtained.
  5. 05HumanNon-randomized trialActivity measurement

    In children, early concentrating capacity did not differ significantly between desmopressin formulations.

    In plain wordsIn children, early urine concentration did not differ significantly between desmopressin formulations.

    Peptide
    Desmopressin
    Outcome
    No significant changeEarly concentrating capacity
    Study

    n = 19

    Comparator
    Desmopressin tablet with a standardized meal
    Outcome group
    Urine Production · Kidney and urinary
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Source sentences

    Summary
    Concentrating capacity demonstrated no significant differences between formulations in the early response phase, in contrast to the plateau phase (p <0.036) and duration of action (p <0.001).
    2 context sentences
    Summary · context
    After achieving maximal diluting capacity a standardized meal was administered, followed by desmopressin tablet (t test) or melt (M-test).
    Summary · context
    Paired data from 4 girls and 15 boys with a mean age of 12.1 years were obtained.
  6. 06HumanNon-randomized trialActivity measurement

    In children, concentrating capacity differed between desmopressin formulations in the plateau phase (p <0.036).

    In plain wordsIn children, urine concentration differed between desmopressin formulations in the plateau phase.

    Peptide
    Desmopressin
    Outcome
    Direction not reportedPlateau concentrating capacity
    Study

    n = 19

    Comparator
    Desmopressin tablet with a standardized meal
    Outcome group
    Urine Production · Kidney and urinary
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Measurements

    P value
    < 0.036
    concentrating capacity, plateau phase, tablet vs melt

    Source sentences

    Summary
    Concentrating capacity demonstrated no significant differences between formulations in the early response phase, in contrast to the plateau phase (p <0.036) and duration of action (p <0.001).
    2 context sentences
    Summary · context
    After achieving maximal diluting capacity a standardized meal was administered, followed by desmopressin tablet (t test) or melt (M-test).
    Summary · context
    Paired data from 4 girls and 15 boys with a mean age of 12.1 years were obtained.
  7. 07HumanNon-randomized trialActivity measurement

    In children, concentrating capacity differed between desmopressin formulations during the duration-of-action phase (p <0.001).

    In plain wordsIn children, late urine concentration differed between desmopressin formulations.

    Peptide
    Desmopressin
    Outcome
    Direction not reportedLate concentrating capacity
    Study

    n = 19

    Comparator
    Desmopressin tablet with a standardized meal
    Outcome group
    Urine Production · Kidney and urinary
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Measurements

    P value
    < 0.001
    concentrating capacity, duration of action, tablet vs melt

    Source sentences

    Summary
    Concentrating capacity demonstrated no significant differences between formulations in the early response phase, in contrast to the plateau phase (p <0.036) and duration of action (p <0.001).
    2 context sentences
    Summary · context
    After achieving maximal diluting capacity a standardized meal was administered, followed by desmopressin tablet (t test) or melt (M-test).
    Summary · context
    Paired data from 4 girls and 15 boys with a mean age of 12.1 years were obtained.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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