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Study · Not a test of the peptide alone · 2011

4 results

The biological activity of Humanin analogs correlates with structure stabilities in solution.

Arakawa T, Niikura T, Kita Y

International journal of biological macromolecules12 Apr 2011Cited by 8 (Europe PMC)

PMID21510972 (opens in a new tab)DOI10.1016/j.ijbiomac.2011.04.003 (opens in a new tab)PepBankPUB-21510972
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    At 10 degrees C in phosphate buffer and in phosphate-buffered saline, humanin and two analogs showed a similar disordered structure.

    In plain wordsIn lab tests at low temperature, humanin and two altered versions all had a similar loose structure.

    Peptide
    Humanin
    Outcome
    No significant changePeptide structure at 10 C
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    These peptides showed a similar disordered structure at 10°C in 10mM phosphate, pH 6.0. They were also similar in phosphate-buffered saline (PBS) as long as the temperature was kept low at 10°C.
    1 context sentence
    Summary · context
    Here, we have studied the effects of buffer and temperature on the structure of these three HN peptides.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    At 37 degrees C, S14G-HN showed small structure changes, while humanin and the inactive S7A-HN showed much larger changes.

    In plain wordsIn lab tests at body temperature, the most active altered humanin kept its structure, while humanin and an inactive version changed much more.

    Peptide
    Humanin
    Outcome
    MixedStructure change at 37 C
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    However, a large difference was observed in both phosphate buffer and PBS between the peptides, when the temperature was raised to a physiological temperature of 37°C. While S14G-HN showed small changes in both solutions at 37°C, the less active HN and inactive S7A-HN showed much larger changes unde…
    1 context sentence
    Summary · context
    Here, we have studied the effects of buffer and temperature on the structure of these three HN peptides.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    Structure change at 37 degrees C was faster for S7A-HN than for humanin.

    In plain wordsIn lab tests at body temperature, an inactive version of humanin changed structure faster than humanin itself.

    Peptide
    Humanin
    Outcome
    Not applicableSpeed of structure change at 37 C
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    In addition, it appeared that structure change at 37°C was faster for S7A-HN than HN.
    1 context sentence
    Summary · context
    Here, we have studied the effects of buffer and temperature on the structure of these three HN peptides.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    Structure stability at 37 degrees C increased in the order S7A-HN, humanin, S14G-HN, in correlation with their neuroprotective activities.

    In plain wordsIn lab tests, how stable each peptide's structure was matched how strongly it protected neurons.

    Peptide
    Humanin
    Outcome
    Not applicableStructure stability versus neuroprotective activity
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    These results show that the structure stability at 37°C increases in the order of S7A-HN, HN and S14G-HN, in correlation with their neuroprotective activities.
    1 context sentence
    Summary · context
    Here, we have studied the effects of buffer and temperature on the structure of these three HN peptides.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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