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Study · Animal study (in vivo) · rat · 2011

4 results

[Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia].

Zarubina IV, Shabanov PD

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2011Cited by 1 (Europe PMC)

PMID21476278 (opens in a new tab)PepBankPUB-21476278
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ischemic rats with different hypoxia resistance, cortagen accelerated recovery of disturbed individual behavior.

    In plain wordsIn rats with brain ischemia and different hypoxia resistance, cortagen accelerated behavioral recovery.

    Peptide
    Cortagen (AEDP)
    Outcome
    IncreaseRecovery of individual behavior
    Study

    ratn: not reported in source

    Chronic brain ischemia in high- and low-hypoxia-resistant rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The polypeptide drug cortexin and the synthetic peptide drug cortagen accelerate the recovery of disturbed individual behavior of ischemic rats with different resistance to hypoxia (high and low resistant rats).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ischemic rats with high or low hypoxia resistance, Cortexin accelerated recovery of disturbed individual behavior.

    In plain wordsIn rats with brain ischemia and different resistance to low oxygen, Cortexin accelerated recovery of disturbed behavior.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseRecovery of individual behavior
    Study

    ratn: not reported in source

    Chronic brain ischemia in rats with high or low resistance to hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The polypeptide drug cortexin and the synthetic peptide drug cortagen accelerate the recovery of disturbed individual behavior of ischemic rats with different resistance to hypoxia (high and low resistant rats).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with chronic brain ischemia, Cortexin prevented excessive activation of lipid peroxidation in brain tissue.

    In plain wordsIn rats with chronic brain ischemia, Cortexin prevented excessive lipid peroxidation in brain tissue.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseLipid peroxidation
    Study

    ratn: not reported in source

    Chronic brain ischemia in rats with high or low resistance to hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, both drugs prevented an excessive activation of lipid peroxidation and a decrease in the antioxidant activity in the brain tissues.
    1 context sentence
    Summary · context
    The polypeptide drug cortexin and the synthetic peptide drug cortagen accelerate the recovery of disturbed individual behavior of ischemic rats with different resistance to hypoxia (high and low resistant rats).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with chronic brain ischemia, Cortexin prevented a decrease in brain tissue antioxidant activity.

    In plain wordsIn rats with chronic brain ischemia, Cortexin prevented a decrease in brain antioxidant activity.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseAntioxidant activity
    Study

    ratn: not reported in source

    Chronic brain ischemia in rats with high or low resistance to hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, both drugs prevented an excessive activation of lipid peroxidation and a decrease in the antioxidant activity in the brain tissues.
    1 context sentence
    Summary · context
    The polypeptide drug cortexin and the synthetic peptide drug cortagen accelerate the recovery of disturbed individual behavior of ischemic rats with different resistance to hypoxia (high and low resistant rats).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    21 Oct 2026, 17:05 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

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