Skip to content

Study · Animal study (in vivo) · rat · 2011

5 results

Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness.

Powers SK, Hudson MB, Nelson WB, Talbert EE, Min K, Szeto HH, Kavazis AN, Smuder AJ

Critical care medicine1 Jul 2011Cited by 224 (Europe PMC)

PMID21460706 (opens in a new tab)PMCIDPMC4995067 (opens in a new tab)DOI10.1097/ccm.0b013e3182190b62 (opens in a new tab)PepBankPUB-21460706
Source linkPubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mechanically ventilated rats, SS‑31 protected the diaphragm against ventilation-induced mitochondrial dysfunction compared with saline.

    In plain wordsIn rats on a ventilator, SS‑31 protected the diaphragm's mitochondria compared with saline.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiaphragm mitochondrial dysfunction
    Study

    ratn: not reported in source

    Mechanically ventilated rats
    Comparator
    Mechanically ventilated rats treated with saline
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared to mechanically ventilated animals treated with saline, animals treated with SS-31 were protected against mechanical ventilation-induced mitochondrial dysfunction, oxidative stress, and protease activation in the diaphragm.
    1 context sentence
    Summary · context
    Cause and effect was determined by preventing mechanical ventilation-induced mitochondrial reactive oxygen species emission in the diaphragm of rats using a novel mitochondria-targeted antioxidant (SS-31).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mechanically ventilated rats, SS‑31 protected the diaphragm against ventilation-induced oxidative stress compared with saline.

    In plain wordsIn rats on a ventilator, SS‑31 lowered oxidative stress in the diaphragm compared with saline.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiaphragm oxidative stress
    Study

    ratn: not reported in source

    Mechanically ventilated rats
    Comparator
    Mechanically ventilated rats treated with saline
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared to mechanically ventilated animals treated with saline, animals treated with SS-31 were protected against mechanical ventilation-induced mitochondrial dysfunction, oxidative stress, and protease activation in the diaphragm.
    1 context sentence
    Summary · context
    Cause and effect was determined by preventing mechanical ventilation-induced mitochondrial reactive oxygen species emission in the diaphragm of rats using a novel mitochondria-targeted antioxidant (SS-31).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mechanically ventilated rats, SS‑31 protected the diaphragm against ventilation-induced protease activation compared with saline.

    In plain wordsIn rats on a ventilator, SS‑31 reduced activation of muscle-breaking enzymes in the diaphragm compared with saline.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiaphragm protease activation
    Study

    ratn: not reported in source

    Mechanically ventilated rats
    Comparator
    Mechanically ventilated rats treated with saline
    Outcome group
    Muscle injury and repair · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared to mechanically ventilated animals treated with saline, animals treated with SS-31 were protected against mechanical ventilation-induced mitochondrial dysfunction, oxidative stress, and protease activation in the diaphragm.
    1 context sentence
    Summary · context
    Cause and effect was determined by preventing mechanical ventilation-induced mitochondrial reactive oxygen species emission in the diaphragm of rats using a novel mitochondria-targeted antioxidant (SS-31).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mechanically ventilated rats, SS‑31 protected the diaphragm against ventilation-induced myofiber atrophy.

    In plain wordsIn rats on a ventilator, SS‑31 protected the diaphragm from muscle fibre shrinkage.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiaphragm myofiber atrophy
    Study

    ratn: not reported in source

    Mechanically ventilated rats
    Comparator
    Mechanically ventilated rats treated with saline
    Outcome group
    Muscle injury and repair · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, treatment of animals with the mitochondrial antioxidant also protected the diaphragm against mechanical ventilation-induced myofiber atrophy and contractile dysfunction.
    1 context sentence
    Summary · context
    Cause and effect was determined by preventing mechanical ventilation-induced mitochondrial reactive oxygen species emission in the diaphragm of rats using a novel mitochondria-targeted antioxidant (SS-31).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mechanically ventilated rats, SS‑31 protected the diaphragm against ventilation-induced contractile dysfunction.

    In plain wordsIn rats on a ventilator, SS‑31 protected the diaphragm from losing contraction strength.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiaphragm contractile dysfunction
    Study

    ratn: not reported in source

    Mechanically ventilated rats
    Comparator
    Mechanically ventilated rats treated with saline
    Outcome group
    Muscle injury and repair · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, treatment of animals with the mitochondrial antioxidant also protected the diaphragm against mechanical ventilation-induced myofiber atrophy and contractile dysfunction.
    1 context sentence
    Summary · context
    Cause and effect was determined by preventing mechanical ventilation-induced mitochondrial reactive oxygen species emission in the diaphragm of rats using a novel mitochondria-targeted antioxidant (SS-31).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.