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Study · Not a test of the peptide alone · 2011

3 results

VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin.

Rossini L, Hashimoto Y, Suzuki H, Kurita M, Gianfriddo M, Scali C, Roncarati R, Franceschini D, Pollio G, Trabalzini L, Terstappen GC, Matsuoka M, Caricasole A

FASEB journal : official publication of the Federation of American Societies for Experimental Biology10 Mar 2011Cited by 27 (Europe PMC)

PMID21393573 (opens in a new tab)DOI10.1096/fj.10-163535 (opens in a new tab)PepBankPUB-21393573
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    VSTM2L interacted with humanin in both yeast and mammalian cells.

    In plain wordsIn yeast and mammalian cells, a protein called VSTM2L bound to humanin.

    Peptide
    Humanin
    Outcome
    Not applicableVSTM2L binding to humanin
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    VSTM2L interacts with HN in both yeast and mammalian cells

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    VSTM2L colocalized with humanin in distinct brain areas and in primary cultured neurons.

    In plain wordsA protein called VSTM2L was found in the same places as humanin in brain areas and in cultured neurons.

    Peptide
    Humanin
    Outcome
    Not applicableVSTM2L colocalization with humanin
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    VSTM2L colocalizes with HN in distinct brain areas as well as in primary cultured neurons

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    In humanin neuroprotection bioassays, VSTM2L acted as a strong antagonist of humanin neuroprotective activity.

    In plain wordsIn lab tests, the protein VSTM2L strongly blocked the protective effect of humanin on neurons.

    Peptide
    Humanin
    Outcome
    DecreaseHumanin neuroprotection in bioassays
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    When tested in HN neuroprotection bioassays, VSTM2L acts as a strong antagonist of HN neuroprotective activity.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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