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Study · Animal study (in vivo) · mouse · 2011

8 results

Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice.

Stengel A, Wang L, Goebel-Stengel M, Taché Y

Neuroreport1 Mar 2011Cited by 84 (Europe PMC)

PMID21386700 (opens in a new tab)PMCIDPMC3063509 (opens in a new tab)DOI10.1097/wnr.0b013e32834558df (opens in a new tab)PepBankPUB-21386700
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intracerebroventricular kisspeptin‑10 at 0.3 μg inhibited the feeding response to an overnight fast by 50% during the 2-3 h period after injection.

    In plain wordsIn mice, a low dose of kisspeptin‑10 in the brain cut eating after a fast by half.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseFeeding response to overnight fast, 2-3 h postinjection
    Study

    mousen: not reported in source

    mice, automated feeding monitoring
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.3 μg/mouse · intracerebroventricularAs given in this study (mouse).

    Measurements

    Inhibition of feeding response
    50%
    0.3 μg/mouse

    Source sentences

    Summary
    Kisspeptin-10 (0.3, 1, and 3 μg/mouse) dose-dependently inhibited the feeding response to an overnight fast by 50, 95, and 90% respectively, during the 2-3 h period postinjection.
    1 context sentence
    Summary · context
    We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intracerebroventricular kisspeptin‑10 at 1 μg inhibited the feeding response to an overnight fast by 95% during the 2-3 h period after injection.

    In plain wordsIn mice, a middle dose of kisspeptin‑10 in the brain almost stopped eating after a fast.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseFeeding response to overnight fast, 2-3 h postinjection
    Study

    mousen: not reported in source

    mice, automated feeding monitoring
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 μg/mouse · intracerebroventricularAs given in this study (mouse).

    Measurements

    Inhibition of feeding response
    95%
    1 μg/mouse

    Source sentences

    Summary
    Kisspeptin-10 (0.3, 1, and 3 μg/mouse) dose-dependently inhibited the feeding response to an overnight fast by 50, 95, and 90% respectively, during the 2-3 h period postinjection.
    1 context sentence
    Summary · context
    We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intracerebroventricular kisspeptin‑10 at 3 μg inhibited the feeding response to an overnight fast by 90% during the 2-3 h period after injection.

    In plain wordsIn mice, a higher dose of kisspeptin‑10 in the brain almost stopped eating after a fast.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseFeeding response to overnight fast, 2-3 h postinjection
    Study

    mousen: not reported in source

    mice, automated feeding monitoring
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    3 μg/mouse · intracerebroventricularAs given in this study (mouse).

    Measurements

    Inhibition of feeding response
    90%
    3 μg/mouse

    Source sentences

    Summary
    Kisspeptin-10 (0.3, 1, and 3 μg/mouse) dose-dependently inhibited the feeding response to an overnight fast by 50, 95, and 90% respectively, during the 2-3 h period postinjection.
    1 context sentence
    Summary · context
    We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intracerebroventricular kisspeptin‑10 at 1 μg reduced 4-h cumulative food intake by 28%.

    In plain wordsIn mice, kisspeptin‑10 given into the brain lowered food eaten over four hours.

    Peptide
    Kisspeptin-10
    Outcome
    Decrease4-h cumulative food intake, intracerebroventricular
    Study

    mousen: not reported in source

    mice, automated feeding monitoring
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 μg/mouse · intracerebroventricularAs given in this study (mouse).

    Measurements

    Reduction in 4-h cumulative food intake
    28%
    1 μg/mouse

    Source sentences

    Summary
    The 1μg/mouse dose reduced the 4-h cumulative food intake by 28%
    1 context sentence
    Summary · context
    We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intraperitoneal kisspeptin‑10 at 10 μg did not reduce 4-h cumulative food intake.

    In plain wordsIn mice, kisspeptin‑10 injected into the belly did not lower food eaten over four hours.

    Peptide
    Kisspeptin-10
    Outcome
    No significant change4-h cumulative food intake, intraperitoneal
    Study

    mousen: not reported in source

    mice, automated feeding monitoring
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    10 μg/mouse · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    whereas intraperitoneal injection (10 μg/mouse) did not.
    1 context sentence
    Summary · context
    We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice, the reduced 4-h food intake after intracerebroventricular kisspeptin‑10 was due to reduced meal frequency.

    In plain wordsIn mice, kisspeptin‑10 in the brain lowered food intake because mice ate fewer meals.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseMeal frequency over 4 h
    Study

    mousen: not reported in source

    mice, automated feeding monitoring
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 μg/mouse · intracerebroventricularAs given in this study (mouse).

    Measurements

    Meal frequency change
    −45 %/4 h
    1 μg/mouse

    Source sentences

    Summary
    The decreased 4-h food intake was due to reduced meal frequency (-45%/4 h)
    2 context sentences
    Summary · context
    The 1μg/mouse dose reduced the 4-h cumulative food intake by 28%
    Summary · context
    We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intracerebroventricular kisspeptin‑10 did not alter meal size.

    In plain wordsIn mice, kisspeptin‑10 in the brain did not change how much they ate in each meal.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeMeal size
    Study

    mousen: not reported in source

    mice, automated feeding monitoring
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 μg/mouse · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    whereas meal size and gastric emptying were not altered.
    2 context sentences
    Summary · context
    The 1μg/mouse dose reduced the 4-h cumulative food intake by 28%
    Summary · context
    We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intracerebroventricular kisspeptin‑10 did not alter gastric emptying.

    In plain wordsIn mice, kisspeptin‑10 in the brain did not change how fast the stomach emptied.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeGastric emptying
    Study

    mousen: not reported in source

    mice, automated feeding monitoring
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 μg/mouse · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    whereas meal size and gastric emptying were not altered.
    2 context sentences
    Summary · context
    The 1μg/mouse dose reduced the 4-h cumulative food intake by 28%
    Summary · context
    We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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