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Study · Measured the body's own peptide · 2011

4 results

β-Thymosins and interstitial lung disease: study of a scleroderma cohort with a one-year follow-up.

De Santis M, Inzitari R, Bosello SL, Peluso G, Fanali C, Iavarone F, Zizzo G, Bocci M, Cabras T, Messana I, Fuso L, Varone F, Pagliari G, Castagnola M, Ferraccioli G

Respiratory research11 Feb 2011Cited by 21 (Europe PMC)

PMID21314931 (opens in a new tab)DOI10.1186/1465-9921-12-22 (opens in a new tab)PepBankPUB-21314931
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In scleroderma patients with interstitial lung disease and in controls, the body's own thymosin beta‑4 was detectable in bronchoalveolar lavage fluid.

    In plain wordsIn people with scleroderma lung disease and in controls, the body's own thymosin beta‑4 was found in lung fluid.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableDetection of thymosin beta-4 in bronchoalveolar lavage fluid
    Study

    n = 61

    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    Thymosin β4, β4 sulfoxide, and β10 were detectable in bronchoalveolar lavage fluid of patients and controls.
    1 context sentence
    Summary · context
    β-thymosins concentrations were determined by reverse phase-high performance liquid chromatography-electrospray-mass spectrometry in the bronchoalveolar lavage fluid of 46 scleroderma patients with lung involvement and of 15 controls.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Bronchoalveolar lavage fluid levels of the body's own thymosin beta‑4 were significantly higher in scleroderma patients with lung involvement than in controls.

    In plain wordsPeople with scleroderma lung disease had higher levels of the body's own thymosin beta‑4 in lung fluid than controls.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta-4 level in bronchoalveolar lavage fluid
    Study

    n = 61

    Comparator
    Controls
    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    Thymosin β4 levels were significantly higher in scleroderma patients than in controls.
    1 context sentence
    Summary · context
    β-thymosins concentrations were determined by reverse phase-high performance liquid chromatography-electrospray-mass spectrometry in the bronchoalveolar lavage fluid of 46 scleroderma patients with lung involvement and of 15 controls.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In scleroderma patients followed for one year, higher levels of the body's own thymosin beta‑4 in lavage fluid seemed to be linked to protection against lung tissue damage.

    In plain wordsIn people with scleroderma, higher natural thymosin beta‑4 levels in lung fluid seemed linked to less lung damage over one year.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableThymosin beta-4 level and lung disease progression at one year
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    In addition, analyzing the progression of scleroderma lung disease at one-year follow-up, we have found that higher thymosin β4 levels seem to have a protective role against lung tissue damage.
    1 context sentence
    Summary · context
    β-thymosins concentrations were determined by reverse phase-high performance liquid chromatography-electrospray-mass spectrometry in the bronchoalveolar lavage fluid of 46 scleroderma patients with lung involvement and of 15 controls.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    Levels of thymosin beta‑4 sulfoxide, an oxidation product of the body's own thymosin beta‑4, were higher in smokers and in scleroderma patients with alveolitis.

    In plain wordsLevels of an oxidized form of the body's own thymosin beta‑4 were higher in smokers and in scleroderma patients with lung inflammation.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta-4 sulfoxide level in smokers and in alveolitis
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    Thymosin β4 sulfoxide levels were higher in the smokers and in the scleroderma patients with alveolitis.
    1 context sentence
    Summary · context
    β-thymosins concentrations were determined by reverse phase-high performance liquid chromatography-electrospray-mass spectrometry in the bronchoalveolar lavage fluid of 46 scleroderma patients with lung involvement and of 15 controls.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

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