In rats given diclofenac, BPC‑157 given intraperitoneally or per-orally was strongly effective and antagonized the gastrointestinal, liver and brain toxicity.
In plain wordsIn rats given diclofenac, BPC‑157 strongly reduced the damage to the gut, liver and brain.
- Peptide
- BPC-157
- Outcome
- DecreaseDiclofenac-induced gastrointestinal, liver and brain toxicity
- Study
ratn: not reported in source
Diclofenac toxicity (12.5 mg/kg intraperitoneally, daily for 3 days)- Outcome group
- Adverse events · Whole body
- Studied dose
- 10 µg/kg, 10 ng/kg (intraperitoneal); 0.16 µg/mL, 0.16 ng/mL (drinking water) · intraperitoneal or per-oral (drinking water) · Throughout the entire experimentAs given in this study (rat).
Source sentences
Already considered a drug that can reverse the toxic side effects of NSAIDs, BPC 157 (10 μg/kg, 10 ng/kg) was strongly effective throughout the entire experiment when given (i) intraperitoneally immediately after diclofenac or (ii) per-orally in drinking water (0.16 μg/mL, 0.16 ng/mL).
2 context sentences(design, population, supporting numbers)
The very extensive antagonization of diclofenac toxicity
This peptide was given to antagonize combined gastrointestinal, liver, and brain toxicity induced by diclofenac (12.5mg/kg intraperitoneally, once daily for 3 days) in rats.