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Study · In vitro (cells) · 2011

2 results

Kisspeptin-10 elicits triphasic cytosolic calcium responses in immortalized GT1-7 GnRH neurones.

Ozcan M, Alcin E, Ayar A, Yilmaz B, Sandal S, Kelestimur H

Neuroscience letters27 Jan 2011Cited by 26 (Europe PMC)

PMID21276835 (opens in a new tab)DOI10.1016/j.neulet.2011.01.054 (opens in a new tab)PepBankPUB-21276835
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In GT1-7 GnRH neurons, kisspeptin‑10 caused a triphasic change in intracellular free calcium: a small increase, then a decrease, then an increase.

    In plain wordsIn cells, kisspeptin‑10 caused calcium inside nerve cells to rise a little, then fall, then rise again.

    Peptide
    Kisspeptin-10
    Outcome
    MixedIntracellular free calcium response
    Study

    n: not reported in source

    Immortalized GT1-7 GnRH neurones
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kisspeptin-10 caused a triphasic change characterized by an initial small increase followed by a significant decrease and increase in intracellular free calcium concentrations ([Ca(2+)](i)).
    1 context sentence
    Summary · context
    Therefore, the pattern of kisspeptin-induced intracellular signaling and the role of PKC in the intracellular signaling cascade were investigated by fluorescence calcium imaging using the immortalized GnRH-secreting GT1-7 hypothalamic neurons.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 02LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In GT1-7 GnRH neurons, pre-treatment with a protein kinase C inhibitor significantly attenuated the kisspeptin‑10-induced calcium changes.

    In plain wordsIn cells, blocking protein kinase C reduced the calcium changes that kisspeptin‑10 caused.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCalcium response with protein kinase C inhibitor pre-treatment
    Study

    n: not reported in source

    Immortalized GT1-7 GnRH neurones
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    The changes in [Ca(2+)](i) were significantly attenuated by pre-treatment with protein kinase C inhibitor.
    1 context sentence
    Summary · context
    Therefore, the pattern of kisspeptin-induced intracellular signaling and the role of PKC in the intracellular signaling cascade were investigated by fluorescence calcium imaging using the immortalized GnRH-secreting GT1-7 hypothalamic neurons.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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