[The clinical significance of thymosin β4 expression in human non-small cell lung cancer].

Hou P, Yu M, Song Z, Li S, Wang E, Qiu X

Zhongguo fei ai za zhi = Chinese journal of lung cancer1 Dec 2004Cited by 2 (Europe PMC)

PMID21251403DOI10.3779/j.issn.1009-3419.2004.06.05PepBankPUB-21251403

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In adults with non-small cell lung cancer, thymosin beta4 expression was high positive in lung cancer tissue (76.3%, 58/76) and low positive in normal lung tissue.
In plain wordsIn adults with lung cancer, the body's own thymosin beta4 was found at higher levels in tumor tissue than in normal lung tissue.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTbeta4 expression in lung cancer versus normal lung tissue
Study
n = 76
Comparator
Neighboring noncancerous lung tissue
Outcome group
Tumor growth · Cancer
Measurements
High-positive Tbeta4 expression
76.3%
lung cancer tissue
Source sentences
Summary
Human Tβ4 expression was high positive in lung cancer tissues (76.3%, 58/76) while low positive in normal lung tissues.
2 context sentences(design, population, supporting numbers)
Summary · context
To study the relationship between human thymosin β4 (Tβ4 )expression and biological factors regarding invasion, metastasis and prognosis of human non-small cell lung cancer (NSCLC).
Summary · context
Tβ4 expression was detected in samples of 76 paraffin-embedded specimens with the neighboring noncancerous tissue using anti-Tβ4 IgY antibody (primary antibody) by immunohistochemical staining.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2125140301
02HumanEndogenous levelObservational studyOther
In adults with non-small cell lung cancer, thymosin beta4 expression was positively associated with TNM stage.
In plain wordsIn adults with lung cancer, higher levels of the body's own thymosin beta4 were linked to a more advanced tumor stage.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTbeta4 expression and TNM stage
Study
n = 76
Outcome group
Tumor growth · Cancer
Measurements
r
0.239
TNM stage
Source sentences
Summary
Tβ4 expression was positively associated with TNM stage (r=0.239, P=0.032)
2 context sentences(design, population, supporting numbers)
Summary · context
To study the relationship between human thymosin β4 (Tβ4 )expression and biological factors regarding invasion, metastasis and prognosis of human non-small cell lung cancer (NSCLC).
Summary · context
Tβ4 expression was detected in samples of 76 paraffin-embedded specimens with the neighboring noncancerous tissue using anti-Tβ4 IgY antibody (primary antibody) by immunohistochemical staining.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2125140302
03HumanEndogenous levelObservational studyOther
In adults with non-small cell lung cancer, thymosin beta4 expression was positively associated with lymphatic metastasis.
In plain wordsIn adults with lung cancer, higher levels of the body's own thymosin beta4 were linked to spread to lymph vessels.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTbeta4 expression and lymphatic metastasis
Study
n = 76
Outcome group
Tumor growth · Cancer
Measurements
r
0.243
lymphatic metastasis
Source sentences
Summary
lymphatic metastasis (r=0.243, P=0.029)
2 context sentences(design, population, supporting numbers)
Summary · context
To study the relationship between human thymosin β4 (Tβ4 )expression and biological factors regarding invasion, metastasis and prognosis of human non-small cell lung cancer (NSCLC).
Summary · context
Tβ4 expression was detected in samples of 76 paraffin-embedded specimens with the neighboring noncancerous tissue using anti-Tβ4 IgY antibody (primary antibody) by immunohistochemical staining.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2125140303
04HumanEndogenous levelObservational studyOther
In adults with non-small cell lung cancer, thymosin beta4 expression was positively associated with venous metastasis.
In plain wordsIn adults with lung cancer, higher levels of the body's own thymosin beta4 were linked to spread into veins.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTbeta4 expression and venous metastasis
Study
n = 76
Outcome group
Tumor growth · Cancer
Measurements
r
0.224
venous metastasis
Source sentences
Summary
venous metastasis (r=0.224, P=0.045)
2 context sentences(design, population, supporting numbers)
Summary · context
To study the relationship between human thymosin β4 (Tβ4 )expression and biological factors regarding invasion, metastasis and prognosis of human non-small cell lung cancer (NSCLC).
Summary · context
Tβ4 expression was detected in samples of 76 paraffin-embedded specimens with the neighboring noncancerous tissue using anti-Tβ4 IgY antibody (primary antibody) by immunohistochemical staining.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2125140304
05HumanEndogenous levelObservational studyOther
In adults with non-small cell lung cancer, thymosin beta4 expression was negatively correlated with cell differentiation.
In plain wordsIn adults with lung cancer, higher levels of the body's own thymosin beta4 were linked to less differentiated tumor cells.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTbeta4 expression and cell differentiation
Study
n = 76
Outcome group
Tumor growth · Cancer
Measurements
r
−0.368
cell differentiation
Source sentences
Summary
A negative correlation was found between Tβ4 expression and cell differentiation (r=-0.368, P=0.002)
2 context sentences(design, population, supporting numbers)
Summary · context
To study the relationship between human thymosin β4 (Tβ4 )expression and biological factors regarding invasion, metastasis and prognosis of human non-small cell lung cancer (NSCLC).
Summary · context
Tβ4 expression was detected in samples of 76 paraffin-embedded specimens with the neighboring noncancerous tissue using anti-Tβ4 IgY antibody (primary antibody) by immunohistochemical staining.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2125140305
06HumanEndogenous levelObservational studyOther
In adults with non-small cell lung cancer, patients with high thymosin beta4 expression had a worse prognosis than those with low expression.
In plain wordsIn adults with lung cancer, high levels of the body's own thymosin beta4 were linked to a worse outlook than low levels.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePrognosis by Tbeta4 expression
Study
n = 76
Comparator
Low Tbeta4 expression
Outcome group
Mortality · Cancer
Source sentences
Summary
Patients with high Tβ4 expression had a worse prognosis than those with low Tβ4 expression (P < 0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
To study the relationship between human thymosin β4 (Tβ4 )expression and biological factors regarding invasion, metastasis and prognosis of human non-small cell lung cancer (NSCLC).
Summary · context
Tβ4 expression was detected in samples of 76 paraffin-embedded specimens with the neighboring noncancerous tissue using anti-Tβ4 IgY antibody (primary antibody) by immunohistochemical staining.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2125140306

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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