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Study · Animal study (in vivo) · rat · 2011

1 result

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway.

Wang P, Xu TY, Guan YF, Tian WW, Viollet B, Rui YC, Zhai QW, Su DF, Miao CY

Annals of neurology19 Jan 2011Cited by 260 (Europe PMC)

PMID21246601 (opens in a new tab)DOI10.1002/ana.22236 (opens in a new tab)PepBankPUB-21246601
Publisher pagePubMedAsk about this study
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental cerebral ischemia, NMN reduced ischemia-induced cerebral injuries.

    In plain wordsIn rats with experimental brain ischemia, NMN reduced brain injuries.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseIschemia-induced cerebral injury
    Study

    ratn: not reported in source

    Experimental cerebral ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Nampt inhibition by a highly-specific Nampt inhibitor, FK866, aggravated brain infarction in experimentally cerebral ischemia rats, whereas Nampt overexpression in local brain and Nampt enzymatic product nicotinamide mononucleotide (NMN) reduced ischemia-induced cerebral injuries.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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