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Study · Not a test of the peptide alone · 2011

3 results

Structure of three Humanin peptides with different activities upon interaction with liposome.

Hirano A, Shiraki K, Niikura T, Arakawa T, Kita Y

International journal of biological macromolecules6 Jan 2011Cited by 6 (Europe PMC)

PMID21215775 (opens in a new tab)DOI10.1016/j.ijbiomac.2010.12.017 (opens in a new tab)PepBankPUB-21215775
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    With DOPG liposome, the S7A and S14G humanin analogs showed a secondary structure indistinguishable from that of humanin.

    In plain wordsIn lab tests with fat-membrane particles, two humanin analogs had the same structure as humanin.

    Peptide
    Humanin
    Outcome
    Not applicableSecondary structure of S7A and S14G analogs with DOPG liposome
    Study

    n: not reported in source

    Synthetic peptides with DOPG liposome
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    These analogs showed a secondary structure indistinguishable from the structure of HN in the presence of DOPG liposome, while unrelated peptides were disordered with and without DOPG.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    Humanin and the analogs, regardless of biological activity, interacted with DOPG liposome and formed an anti-parallel β-sheet structure.

    In plain wordsIn lab tests with fat-membrane particles, humanin and two analogs took the same sheet-like shape, whether or not they were active.

    Peptide
    Humanin
    Outcome
    Not applicableAnti-parallel β-sheet formation of humanin and analogs with DOPG liposome
    Study

    n: not reported in source

    Synthetic peptides with DOPG liposome
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    It thus appeared that HN and the analogs, regardless of the biological activities, have an ability to interact with DOPG liposome and form an anti-parallel β-sheet structure.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    In buffer at physiological temperature, the S14G analog showed greater stability as a disordered structure than wild type humanin and the S7A analog.

    In plain wordsIn lab tests in buffer, the S14G analog kept its loose, disordered shape better than humanin and the S7A analog.

    Peptide
    Humanin
    Outcome
    Not applicableDisordered structure stability of S14G analog in buffer
    Study

    n: not reported in source

    Synthetic peptides with DOPG liposome
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    While the wild type HN and the S7A and S14G analogs were largely disordered in buffer, the S14G analog showed greater stability as a disordered structure in the buffer at a physiological temperature, suggesting that it maintains the disordered structure presumably required for the interaction with t…

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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