Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms.

Luque RM, Córdoba-Chacón J, Gahete MD, Navarro VM, Tena-Sempere M, Kineman RD, Castaño JP

Endocrinology5 Jan 2011Cited by 76 (Europe PMC)

PMID21209013PMCIDPMC3198963DOI10.1210/en.2010-1142PepBankPUB-21209013

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

9 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In primary baboon pituitary cell cultures, Kp-10 stimulated LH release in a dose-dependent and time-dependent way.
In plain wordsIn lab-grown baboon pituitary cells, kisspeptin‑10 raised release of luteinizing hormone, more with higher dose and longer time.
Peptide
Kisspeptin-10
Outcome
IncreaseLH release from baboon pituitary cells
Study
baboonn: not reported in source
primary pituitary cell cultures from female baboons (Papio anubis)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
The stimulatory effect of Kp-10 on LH and GH release was dose and time dependent
1 context sentence(design, population, supporting numbers)
Summary · context
We present herein evidence that Kps (specifically Kp-10) can also stimulate LH and GH release in primary pituitary cell cultures prepared from female baboons (Papio anubis), a species that more closely models human physiology.
Report a problemFND-2120901301
02LabIn vitro (cells)Efficacy outcome
In primary baboon pituitary cell cultures, Kp-10 stimulated GH release in a dose-dependent and time-dependent way.
In plain wordsIn lab-grown baboon pituitary cells, kisspeptin‑10 raised release of growth hormone, more with higher dose and longer time.
Peptide
Kisspeptin-10
Outcome
IncreaseGH release from baboon pituitary cells
Study
baboonn: not reported in source
primary pituitary cell cultures from female baboons (Papio anubis)
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
The stimulatory effect of Kp-10 on LH and GH release was dose and time dependent
1 context sentence(design, population, supporting numbers)
Summary · context
We present herein evidence that Kps (specifically Kp-10) can also stimulate LH and GH release in primary pituitary cell cultures prepared from female baboons (Papio anubis), a species that more closely models human physiology.
Report a problemFND-2120901302
03LabIn vitro (cells)Efficacy outcome
In primary baboon pituitary cell cultures, Kp-10 enhanced the LH response to GnRH.
In plain wordsIn lab-grown baboon pituitary cells, kisspeptin‑10 made the luteinizing hormone response to GnRH stronger.
Peptide
Kisspeptin-10
Outcome
IncreaseLH response to GnRH with Kp-10
Study
baboonn: not reported in source
primary pituitary cell cultures from female baboons (Papio anubis)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
enhanced the hormonal responses to their major regulators (GnRH for LH; GHRH/ghrelin for GH)
1 context sentence(design, population, supporting numbers)
Summary · context
We present herein evidence that Kps (specifically Kp-10) can also stimulate LH and GH release in primary pituitary cell cultures prepared from female baboons (Papio anubis), a species that more closely models human physiology.
Report a problemFND-2120901303
04LabIn vitro (cells)Efficacy outcome
In primary baboon pituitary cell cultures, Kp-10 enhanced the GH response to GHRH and ghrelin.
In plain wordsIn lab-grown baboon pituitary cells, kisspeptin‑10 made the growth hormone response to GHRH and ghrelin stronger.
Peptide
Kisspeptin-10
Outcome
IncreaseGH response to GHRH/ghrelin with Kp-10
Study
baboonn: not reported in source
primary pituitary cell cultures from female baboons (Papio anubis)
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
enhanced the hormonal responses to their major regulators (GnRH for LH; GHRH/ghrelin for GH)
1 context sentence(design, population, supporting numbers)
Summary · context
We present herein evidence that Kps (specifically Kp-10) can also stimulate LH and GH release in primary pituitary cell cultures prepared from female baboons (Papio anubis), a species that more closely models human physiology.
Report a problemFND-2120901304
05LabIn vitro (cells)Efficacy outcome
In primary baboon pituitary cell cultures, Kp-10 did not affect release of TSH, FSH, ACTH or prolactin.
In plain wordsIn lab-grown baboon pituitary cells, kisspeptin‑10 did not change release of four other pituitary hormones.
Peptide
Kisspeptin-10
Outcome
No significant changeRelease of TSH, FSH, ACTH and prolactin
Study
baboonn: not reported in source
primary pituitary cell cultures from female baboons (Papio anubis)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
without affecting the release of other pituitary hormones (TSH, FSH, ACTH, prolactin).
1 context sentence(design, population, supporting numbers)
Summary · context
We present herein evidence that Kps (specifically Kp-10) can also stimulate LH and GH release in primary pituitary cell cultures prepared from female baboons (Papio anubis), a species that more closely models human physiology.
Report a problemFND-2120901305
06LabIn vitro (cells)Mechanism
In primary baboon pituitary cells, blockers showed that Kp-10 stimulates LH and GH release through phospholipase C, protein kinase C, MAPK and intracellular Ca(2+) mobilization.
In plain wordsIn lab-grown baboon pituitary cells, kisspeptin‑10 raised hormone release through several known cell signaling steps.
Peptide
Kisspeptin-10
Outcome
Not applicableSignaling pathways of Kp-10 for LH and GH release (involved)
Study
baboonn: not reported in source
primary pituitary cell cultures from female baboons (Papio anubis)
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Use of pharmacological intracellular signaling blockers indicated Kp-10 signals through phospholipase C, protein kinase C, MAPK, and intracellular Ca(2+) mobilization
1 context sentence(design, population, supporting numbers)
Summary · context
We present herein evidence that Kps (specifically Kp-10) can also stimulate LH and GH release in primary pituitary cell cultures prepared from female baboons (Papio anubis), a species that more closely models human physiology.
Report a problemFND-2120901306
07LabIn vitro (cells)Mechanism
In primary baboon pituitary cells, blockers showed that Kp-10 does not act through adenylyl cyclase, protein kinase A, extracellular Ca(2+) influx through L-type channels, or nitric oxide synthase.
In plain wordsIn lab-grown baboon pituitary cells, kisspeptin‑10 did not use four other signaling steps to raise hormone release.
Peptide
Kisspeptin-10
Outcome
No significant changeSignaling pathways of Kp-10 for LH and GH release (not involved)
Study
baboonn: not reported in source
primary pituitary cell cultures from female baboons (Papio anubis)
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
but not adenylyl cyclase, protein kinase A, extracellular Ca(2+) influx (through L-type channels), or nitric oxide synthase, to stimulate both LH and GH release.
1 context sentence(design, population, supporting numbers)
Summary · context
We present herein evidence that Kps (specifically Kp-10) can also stimulate LH and GH release in primary pituitary cell cultures prepared from female baboons (Papio anubis), a species that more closely models human physiology.
Report a problemFND-2120901307
08LabIn vitro (cells)Mechanism
In primary baboon pituitary cells, blockade of mTOR or PI3K activity fully abolished the stimulatory effect of Kp-10 on LH release.
In plain wordsIn lab-grown baboon pituitary cells, blocking two signaling enzymes fully stopped the kisspeptin‑10 rise in luteinizing hormone release.
Peptide
Kisspeptin-10
Outcome
DecreaseEffect of mTOR or PI3K blockade on Kp-10 stimulated LH release
Study
baboonn: not reported in source
primary pituitary cell cultures from female baboons (Papio anubis)
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
blockade of mammalian target of rapamycin or phosphoinositol 3-kinase activity fully abolished the stimulatory effect of Kp-10 on LH but not GH release.
1 context sentence(design, population, supporting numbers)
Summary · context
We present herein evidence that Kps (specifically Kp-10) can also stimulate LH and GH release in primary pituitary cell cultures prepared from female baboons (Papio anubis), a species that more closely models human physiology.
Report a problemFND-2120901308
09LabIn vitro (cells)Mechanism
In primary baboon pituitary cells, blockade of mTOR or PI3K activity did not abolish the stimulatory effect of Kp-10 on GH release.
In plain wordsIn lab-grown baboon pituitary cells, blocking two signaling enzymes did not stop the kisspeptin‑10 rise in growth hormone release.
Peptide
Kisspeptin-10
Outcome
No significant changeEffect of mTOR or PI3K blockade on Kp-10 stimulated GH release
Study
baboonn: not reported in source
primary pituitary cell cultures from female baboons (Papio anubis)
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
blockade of mammalian target of rapamycin or phosphoinositol 3-kinase activity fully abolished the stimulatory effect of Kp-10 on LH but not GH release.
1 context sentence(design, population, supporting numbers)
Summary · context
We present herein evidence that Kps (specifically Kp-10) can also stimulate LH and GH release in primary pituitary cell cultures prepared from female baboons (Papio anubis), a species that more closely models human physiology.
Report a problemFND-2120901309

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

10LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Efficacy outcome
In primary baboon pituitary cells, estradiol enhanced the relative LH response to Kp-10, alone or combined with GnRH.
In plain wordsIn lab-grown baboon pituitary cells, estradiol made the luteinizing hormone response to kisspeptin‑10 stronger.
Peptide
Kisspeptin-10
Outcome
IncreaseEffect of estradiol on the LH response to Kp-10
Study
baboonn: not reported in source
primary pituitary cell cultures from female baboons (Papio anubis)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Of note, estradiol enhanced the relative LH response to Kp-10, alone or in combination with GnRH.
1 context sentence(design, population, supporting numbers)
Summary · context
We present herein evidence that Kps (specifically Kp-10) can also stimulate LH and GH release in primary pituitary cell cultures prepared from female baboons (Papio anubis), a species that more closely models human physiology.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2120901310

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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