Intraperitoneal kisspeptin-10 administration induces dose-dependent degenerative changes in maturing rat testes.

Ramzan F, Qureshi IZ

Life sciences26 Nov 2010Cited by 29 (Europe PMC)

PMID21112339DOI10.1016/j.lfs.2010.11.019PepBankPUB-21112339

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal male rats, 12 days of kisspeptin‑10 reduced plasma LH at the 1 ng and 1 μg doses.
In plain wordsIn young male rats, 12 days of kisspeptin‑10 lowered blood LH at the 1 ng and 1 μg doses.
Peptide
Kisspeptin-10
Outcome
DecreasePlasma LH concentration
Study
ratn: not reported in source
Prepubertal male rats, 5 weeks old
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1 ng and 1 μg · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
At the end of the treatments plasma LH and testosterone concentrations were reduced significantly at 1ng and 1μg kisspeptin doses (P<0.05; P<0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the effects of 12 days of pulsatile kisspeptin administration on gonadotropins and testosterone release and maturation of immature male gonads.
Summary · context
Kisspeptin-10 was administered intraperitoneally at different dosage concentrations (1 μg, 1 ng, and 10 pg) to 5 weeks old prepubertal male rats, twice daily for 12 days.
Report a problemFND-2111233901
02AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal male rats, 12 days of kisspeptin‑10 reduced plasma testosterone at the 1 ng and 1 μg doses.
In plain wordsIn young male rats, 12 days of kisspeptin‑10 lowered blood testosterone at the 1 ng and 1 μg doses.
Peptide
Kisspeptin-10
Outcome
DecreasePlasma testosterone concentration
Study
ratn: not reported in source
Prepubertal male rats, 5 weeks old
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1 ng and 1 μg · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
At the end of the treatments plasma LH and testosterone concentrations were reduced significantly at 1ng and 1μg kisspeptin doses (P<0.05; P<0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the effects of 12 days of pulsatile kisspeptin administration on gonadotropins and testosterone release and maturation of immature male gonads.
Summary · context
Kisspeptin-10 was administered intraperitoneally at different dosage concentrations (1 μg, 1 ng, and 10 pg) to 5 weeks old prepubertal male rats, twice daily for 12 days.
Report a problemFND-2111233902
03AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal male rats, kisspeptin‑10 decreased the numbers of type A spermatogonia, preleptotene and pachytene spermatocytes, step 7 and elongated spermatids.
In plain wordsIn young male rats, kisspeptin‑10 reduced the numbers of several sperm-forming cell types in the testes.
Peptide
Kisspeptin-10
Outcome
DecreaseGerm cell numbers at stage VII
Study
ratn: not reported in source
Prepubertal male rats, 5 weeks old
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
Type A spermatogonia, preleptotene spermatocytes, pachytene spermatocytes, step 7 spermatids, elongated spermatids
3 context sentences(design, population, supporting numbers)
Summary · context
Spermatogenesis was studied mainly at stage VII of the spermatogenic cycle through light and electron microscopy.
Summary · context
The present study investigated the effects of 12 days of pulsatile kisspeptin administration on gonadotropins and testosterone release and maturation of immature male gonads.
Summary · context
Kisspeptin-10 was administered intraperitoneally at different dosage concentrations (1 μg, 1 ng, and 10 pg) to 5 weeks old prepubertal male rats, twice daily for 12 days.
Report a problemFND-2111233903
04AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal male rats, kisspeptin‑10 decreased daily sperm production.
In plain wordsIn young male rats, kisspeptin‑10 lowered daily sperm production.
Peptide
Kisspeptin-10
Outcome
DecreaseDaily sperm production
Study
ratn: not reported in source
Prepubertal male rats, 5 weeks old
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
daily sperm production decreased significantly (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the effects of 12 days of pulsatile kisspeptin administration on gonadotropins and testosterone release and maturation of immature male gonads.
Summary · context
Kisspeptin-10 was administered intraperitoneally at different dosage concentrations (1 μg, 1 ng, and 10 pg) to 5 weeks old prepubertal male rats, twice daily for 12 days.
Report a problemFND-2111233904
05AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal male rats, kisspeptin‑10 reduced Sertoli cell efficiency at all doses.
In plain wordsIn young male rats, kisspeptin‑10 reduced the efficiency of testis support cells at all doses.
Peptide
Kisspeptin-10
Outcome
DecreaseSertoli cell efficiency
Study
ratn: not reported in source
Prepubertal male rats, 5 weeks old
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 μg, 1 ng and 10 pg · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
Sertoli cell efficiency and total support capacity of Sertoli cells were reduced at all doses (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the effects of 12 days of pulsatile kisspeptin administration on gonadotropins and testosterone release and maturation of immature male gonads.
Summary · context
Kisspeptin-10 was administered intraperitoneally at different dosage concentrations (1 μg, 1 ng, and 10 pg) to 5 weeks old prepubertal male rats, twice daily for 12 days.
Report a problemFND-2111233905
06AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal male rats, kisspeptin‑10 reduced the total support capacity of Sertoli cells at all doses.
In plain wordsIn young male rats, kisspeptin‑10 reduced the support capacity of testis support cells at all doses.
Peptide
Kisspeptin-10
Outcome
DecreaseTotal support capacity of Sertoli cells
Study
ratn: not reported in source
Prepubertal male rats, 5 weeks old
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 μg, 1 ng and 10 pg · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
Sertoli cell efficiency and total support capacity of Sertoli cells were reduced at all doses (P<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the effects of 12 days of pulsatile kisspeptin administration on gonadotropins and testosterone release and maturation of immature male gonads.
Summary · context
Kisspeptin-10 was administered intraperitoneally at different dosage concentrations (1 μg, 1 ng, and 10 pg) to 5 weeks old prepubertal male rats, twice daily for 12 days.
Report a problemFND-2111233906
07AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal male rats, the meiotic index decreased with kisspeptin‑10 at the 1 μg dose only.
In plain wordsIn young male rats, kisspeptin‑10 lowered a measure of sperm cell division only at the 1 μg dose.
Peptide
Kisspeptin-10
Outcome
DecreaseMeiotic index
Study
ratn: not reported in source
Prepubertal male rats, 5 weeks old
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 μg · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
Meiotic index decreased (P<0.05) at 1 μg dose only
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the effects of 12 days of pulsatile kisspeptin administration on gonadotropins and testosterone release and maturation of immature male gonads.
Summary · context
Kisspeptin-10 was administered intraperitoneally at different dosage concentrations (1 μg, 1 ng, and 10 pg) to 5 weeks old prepubertal male rats, twice daily for 12 days.
Report a problemFND-2111233907
08AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal male rats, the coefficient of mitosis increased with kisspeptin‑10 at the 1 ng and 1 μg doses.
In plain wordsIn young male rats, kisspeptin‑10 raised a measure of cell division at the 1 ng and 1 μg doses.
Peptide
Kisspeptin-10
Outcome
IncreaseCoefficient of mitosis
Study
ratn: not reported in source
Prepubertal male rats, 5 weeks old
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 ng and 1 μg · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
whereas coefficient of mitosis increased at 1 ng and 1 μg (P<0.01) kisspeptin doses.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the effects of 12 days of pulsatile kisspeptin administration on gonadotropins and testosterone release and maturation of immature male gonads.
Summary · context
Kisspeptin-10 was administered intraperitoneally at different dosage concentrations (1 μg, 1 ng, and 10 pg) to 5 weeks old prepubertal male rats, twice daily for 12 days.
Report a problemFND-2111233908
09AnimalAnimal study (in vivo)Safety outcome
In prepubertal male rats, kisspeptin‑10 caused degeneration of seminiferous tubules with tubular necrosis, giant cells, vacuolization and widened lumen.
In plain wordsIn young male rats, kisspeptin‑10 damaged the sperm-forming tubes of the testes.
Peptide
Kisspeptin-10
Outcome
IncreaseSeminiferous tubule degeneration (histology)
Study
ratn: not reported in source
Prepubertal male rats, 5 weeks old
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
Histologically, degeneration of seminiferous tubules was evident showing tubular necrosis, multinucleated giant cell formation, intratubular vacuolization, widened lumen and deshaped germ cells.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the effects of 12 days of pulsatile kisspeptin administration on gonadotropins and testosterone release and maturation of immature male gonads.
Summary · context
Kisspeptin-10 was administered intraperitoneally at different dosage concentrations (1 μg, 1 ng, and 10 pg) to 5 weeks old prepubertal male rats, twice daily for 12 days.
Report a problemFND-2111233909
10AnimalAnimal study (in vivo)Safety outcome
In prepubertal male rats, kisspeptin‑10 caused ultrastructural changes: thin basal laminae, enlarged intratubular spaces, abnormal acrosomes and disrupted germ cells.
In plain wordsIn young male rats, kisspeptin‑10 changed the fine structure of the testes and disrupted sperm-forming cells.
Peptide
Kisspeptin-10
Outcome
IncreaseTestis ultrastructural changes
Study
ratn: not reported in source
Prepubertal male rats, 5 weeks old
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
Marked ultrastructural changes characterized by thin basal laminae, enlarged intratubular spaces, abnormal acrosome and disrupted germ cells were noticeable.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study investigated the effects of 12 days of pulsatile kisspeptin administration on gonadotropins and testosterone release and maturation of immature male gonads.
Summary · context
Kisspeptin-10 was administered intraperitoneally at different dosage concentrations (1 μg, 1 ng, and 10 pg) to 5 weeks old prepubertal male rats, twice daily for 12 days.
Report a problemFND-2111233910

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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