Estimation of human effective absorbed dose of 67Ga-cDTPA-gonadorelin based on biodistribution rat data.

Shanehsazzadeh S, Lahooti A, Sadeghi HR, Jalilian AR

Nuclear medicine communications1 Jan 2011Cited by 13 (Europe PMC)

PMID21068688DOI10.1097/mnm.0b013e328340b916PepBankPUB-21068688

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Gonadorelin (GnRH, LHRH).

01AnimalNot a test of Gonadorelin (GnRH, LHRH) aloneAnimal study (in vivo)Pharmacokinetics
In normal rats, 67Ga-cDTPA-GnRH showed high breast uptake.
In plain wordsIn rats, labelled gonadorelin showed high uptake in the breast.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableBreast uptake of 67Ga-cDTPA-GnRH
Study
ratn: not reported in source
Normal rats
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
The biodistribution of 67Ga-cDTPA-GnRH in rats showed high breast uptake and low muscle and blood uptake.
1 context sentence(design, population, supporting numbers)
Summary · context
In this investigation, we estimated the effective absorbed dose of radiation into human organs, after an intravenous administration of gallium-67 (67Ga)-labeled gonadorelin, one of the gonadotropin-releasing hormone (GnRH) agonists, using biodistribution data from injected normal rats.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-2106868806
02AnimalNot a test of Gonadorelin (GnRH, LHRH) aloneAnimal study (in vivo)Pharmacokinetics
In normal rats, 67Ga-cDTPA-GnRH showed low muscle uptake.
In plain wordsIn rats, labelled gonadorelin showed low uptake in muscle.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableMuscle uptake of 67Ga-cDTPA-GnRH
Study
ratn: not reported in source
Normal rats
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
The biodistribution of 67Ga-cDTPA-GnRH in rats showed high breast uptake and low muscle and blood uptake.
1 context sentence(design, population, supporting numbers)
Summary · context
In this investigation, we estimated the effective absorbed dose of radiation into human organs, after an intravenous administration of gallium-67 (67Ga)-labeled gonadorelin, one of the gonadotropin-releasing hormone (GnRH) agonists, using biodistribution data from injected normal rats.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-2106868807
03AnimalNot a test of Gonadorelin (GnRH, LHRH) aloneAnimal study (in vivo)Pharmacokinetics
In normal rats, 67Ga-cDTPA-GnRH showed low blood uptake.
In plain wordsIn rats, labelled gonadorelin showed low uptake in blood.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableBlood uptake of 67Ga-cDTPA-GnRH
Study
ratn: not reported in source
Normal rats
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
The biodistribution of 67Ga-cDTPA-GnRH in rats showed high breast uptake and low muscle and blood uptake.
1 context sentence(design, population, supporting numbers)
Summary · context
In this investigation, we estimated the effective absorbed dose of radiation into human organs, after an intravenous administration of gallium-67 (67Ga)-labeled gonadorelin, one of the gonadotropin-releasing hormone (GnRH) agonists, using biodistribution data from injected normal rats.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-2106868808
04Computer modelNot a test of Gonadorelin (GnRH, LHRH) aloneIn silicoOther
Extrapolated from rat data, a 185-MBq injection of 67Ga-cDTPA-GnRH in humans might give an absorbed dose of 5.26 mGy in the whole body.
In plain wordsA computer estimate from rat data gives a whole-body dose of 5.26 mGy for a 185-MBq injection of labelled gonadorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableEstimated whole-body absorbed dose
Study
n: not reported in source
Dose extrapolation from rat biodistribution data (MIRD)
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Absorbed dose, whole body
5.26 mGy
185-MBq injection
Source sentences
Summary
From rat data we estimated that a 185-MBq injection of 67Ga-cDTPA-GnRH into the humans might result in an estimated absorbed dose of 5.26 mGy in the whole body with the highest effective absorbed dose was in the lungs (2.73 mSv), and the organs that received the next highest doses were the bladder w…
1 context sentence(design, population, supporting numbers)
Summary · context
In this investigation, we estimated the effective absorbed dose of radiation into human organs, after an intravenous administration of gallium-67 (67Ga)-labeled gonadorelin, one of the gonadotropin-releasing hormone (GnRH) agonists, using biodistribution data from injected normal rats.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-2106868801
05Computer modelNot a test of Gonadorelin (GnRH, LHRH) aloneIn silicoOther
Extrapolated from rat data, the lungs would receive the highest effective absorbed dose, 2.73 mSv, after a 185-MBq injection of 67Ga-cDTPA-GnRH.
In plain wordsA computer estimate from rat data gives the lungs the highest dose, 2.73 mSv, from labelled gonadorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableEstimated effective absorbed dose in lungs
Study
n: not reported in source
Dose extrapolation from rat biodistribution data (MIRD)
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Effective absorbed dose, lungs
2.73 mSv
185-MBq injection
Source sentences
Summary
From rat data we estimated that a 185-MBq injection of 67Ga-cDTPA-GnRH into the humans might result in an estimated absorbed dose of 5.26 mGy in the whole body with the highest effective absorbed dose was in the lungs (2.73 mSv), and the organs that received the next highest doses were the bladder w…
1 context sentence(design, population, supporting numbers)
Summary · context
In this investigation, we estimated the effective absorbed dose of radiation into human organs, after an intravenous administration of gallium-67 (67Ga)-labeled gonadorelin, one of the gonadotropin-releasing hormone (GnRH) agonists, using biodistribution data from injected normal rats.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-2106868802
06Computer modelNot a test of Gonadorelin (GnRH, LHRH) aloneIn silicoOther
Extrapolated from rat data, the bladder wall would receive an effective absorbed dose of 1.59 mSv after a 185-MBq injection of 67Ga-cDTPA-GnRH.
In plain wordsA computer estimate from rat data gives the bladder wall 1.59 mSv from labelled gonadorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableEstimated effective absorbed dose in bladder wall
Study
n: not reported in source
Dose extrapolation from rat biodistribution data (MIRD)
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Effective absorbed dose, bladder wall
1.59 mSv
185-MBq injection
Source sentences
Summary
From rat data we estimated that a 185-MBq injection of 67Ga-cDTPA-GnRH into the humans might result in an estimated absorbed dose of 5.26 mGy in the whole body with the highest effective absorbed dose was in the lungs (2.73 mSv), and the organs that received the next highest doses were the bladder w…
1 context sentence(design, population, supporting numbers)
Summary · context
In this investigation, we estimated the effective absorbed dose of radiation into human organs, after an intravenous administration of gallium-67 (67Ga)-labeled gonadorelin, one of the gonadotropin-releasing hormone (GnRH) agonists, using biodistribution data from injected normal rats.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-2106868803
07Computer modelNot a test of Gonadorelin (GnRH, LHRH) aloneIn silicoOther
Extrapolated from rat data, the liver would receive an effective absorbed dose of 0.80 mSv after a 185-MBq injection of 67Ga-cDTPA-GnRH.
In plain wordsA computer estimate from rat data gives the liver 0.80 mSv from labelled gonadorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableEstimated effective absorbed dose in liver
Study
n: not reported in source
Dose extrapolation from rat biodistribution data (MIRD)
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Effective absorbed dose, liver
0.8 mSv
185-MBq injection
Source sentences
Summary
From rat data we estimated that a 185-MBq injection of 67Ga-cDTPA-GnRH into the humans might result in an estimated absorbed dose of 5.26 mGy in the whole body with the highest effective absorbed dose was in the lungs (2.73 mSv), and the organs that received the next highest doses were the bladder w…
1 context sentence(design, population, supporting numbers)
Summary · context
In this investigation, we estimated the effective absorbed dose of radiation into human organs, after an intravenous administration of gallium-67 (67Ga)-labeled gonadorelin, one of the gonadotropin-releasing hormone (GnRH) agonists, using biodistribution data from injected normal rats.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-2106868804
08Computer modelNot a test of Gonadorelin (GnRH, LHRH) aloneIn silicoOther
Extrapolated from rat data, the bone marrow would receive an effective absorbed dose of 0.52 mSv after a 185-MBq injection of 67Ga-cDTPA-GnRH.
In plain wordsA computer estimate from rat data gives bone marrow 0.52 mSv from labelled gonadorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableEstimated effective absorbed dose in bone marrow
Study
n: not reported in source
Dose extrapolation from rat biodistribution data (MIRD)
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Effective absorbed dose, bone marrow
0.52 mSv
185-MBq injection
Source sentences
Summary
From rat data we estimated that a 185-MBq injection of 67Ga-cDTPA-GnRH into the humans might result in an estimated absorbed dose of 5.26 mGy in the whole body with the highest effective absorbed dose was in the lungs (2.73 mSv), and the organs that received the next highest doses were the bladder w…
1 context sentence(design, population, supporting numbers)
Summary · context
In this investigation, we estimated the effective absorbed dose of radiation into human organs, after an intravenous administration of gallium-67 (67Ga)-labeled gonadorelin, one of the gonadotropin-releasing hormone (GnRH) agonists, using biodistribution data from injected normal rats.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-2106868805

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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