Bone loss in ovariectomized rats: dominant role for estrogen but apparently not for FSH.

Rouach V, Katzburg S, Koch Y, Stern N, Somjen D

Journal of cellular biochemistry1 Jan 2011Cited by 22 (Europe PMC)

PMID21053364DOI10.1002/jcb.22908PepBankPUB-21053364

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats treated with decapeptyl, serum FSH was suppressed.
In plain wordsIn rats with removed ovaries, decapeptyl suppressed FSH levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFSH suppression
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · injection · 10 weeksAs given in this study (rat).
Source sentences
Summary
In decapeptyl treated OVX rats, FSH and LH levels were suppressed, the organization of growth plate and the trabecular bone were disrupted, and there were fewer proliferative and chondroblastic cells and a large adipocytes population in bone marrow, but an increased trabecular bone volume (TBV).
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
Report a problemFND-2105336401
02AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats treated with decapeptyl, serum LH was suppressed.
In plain wordsIn rats with removed ovaries, decapeptyl suppressed LH levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH suppression
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · injection · 10 weeksAs given in this study (rat).
Source sentences
Summary
In decapeptyl treated OVX rats, FSH and LH levels were suppressed, the organization of growth plate and the trabecular bone were disrupted, and there were fewer proliferative and chondroblastic cells and a large adipocytes population in bone marrow, but an increased trabecular bone volume (TBV).
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
Report a problemFND-2105336402
03AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats treated with decapeptyl, trabecular bone volume increased.
In plain wordsIn rats with removed ovaries, trabecular bone volume increased during decapeptyl treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseTrabecular bone volume
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · injection · 10 weeksAs given in this study (rat).
Source sentences
Summary
In decapeptyl treated OVX rats, FSH and LH levels were suppressed, the organization of growth plate and the trabecular bone were disrupted, and there were fewer proliferative and chondroblastic cells and a large adipocytes population in bone marrow, but an increased trabecular bone volume (TBV).
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
Report a problemFND-2105336408

Studies that did not test the peptide alone9

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

04AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats treated with decapeptyl, growth plate organization was disrupted.
In plain wordsIn rats with removed ovaries, growth plate organization was disrupted during decapeptyl treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableGrowth plate organization
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In decapeptyl treated OVX rats, FSH and LH levels were suppressed, the organization of growth plate and the trabecular bone were disrupted, and there were fewer proliferative and chondroblastic cells and a large adipocytes population in bone marrow, but an increased trabecular bone volume (TBV).
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2105336403
05AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats treated with decapeptyl, trabecular bone organization was disrupted.
In plain wordsIn rats with removed ovaries, trabecular bone organization was disrupted during decapeptyl treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableTrabecular bone organization
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In decapeptyl treated OVX rats, FSH and LH levels were suppressed, the organization of growth plate and the trabecular bone were disrupted, and there were fewer proliferative and chondroblastic cells and a large adipocytes population in bone marrow, but an increased trabecular bone volume (TBV).
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2105336404
06AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats treated with decapeptyl, fewer proliferative cells were observed.
In plain wordsIn rats with removed ovaries, fewer proliferative cells were observed during decapeptyl treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseProliferative cells
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In decapeptyl treated OVX rats, FSH and LH levels were suppressed, the organization of growth plate and the trabecular bone were disrupted, and there were fewer proliferative and chondroblastic cells and a large adipocytes population in bone marrow, but an increased trabecular bone volume (TBV).
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2105336405
07AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats treated with decapeptyl, fewer chondroblastic cells were observed.
In plain wordsIn rats with removed ovaries, fewer cartilage-forming cells were observed during decapeptyl treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseChondroblastic cells
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In decapeptyl treated OVX rats, FSH and LH levels were suppressed, the organization of growth plate and the trabecular bone were disrupted, and there were fewer proliferative and chondroblastic cells and a large adipocytes population in bone marrow, but an increased trabecular bone volume (TBV).
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2105336406
08AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats treated with decapeptyl, bone marrow contained a large adipocyte population.
In plain wordsIn rats with removed ovaries, bone marrow contained many fat cells during decapeptyl treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableBone marrow adipocytes
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In decapeptyl treated OVX rats, FSH and LH levels were suppressed, the organization of growth plate and the trabecular bone were disrupted, and there were fewer proliferative and chondroblastic cells and a large adipocytes population in bone marrow, but an increased trabecular bone volume (TBV).
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2105336407
09AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, estradiol plus decapeptyl suppressed FSH levels.
In plain wordsIn rats with removed ovaries, estradiol plus decapeptyl suppressed FSH levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFSH with combined treatment
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In the E(2) + decapeptyl treatment, FSH and LH levels were suppressed, with partially restored growth plate architecture and improved TBV.
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2105336409
10AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, estradiol plus decapeptyl suppressed LH levels.
In plain wordsIn rats with removed ovaries, estradiol plus decapeptyl suppressed LH levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH with combined treatment
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In the E(2) + decapeptyl treatment, FSH and LH levels were suppressed, with partially restored growth plate architecture and improved TBV.
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2105336410
11AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, estradiol plus decapeptyl partially restored growth plate architecture.
In plain wordsIn rats with removed ovaries, estradiol plus decapeptyl partially restored growth plate structure.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableGrowth plate architecture with combined treatment
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In the E(2) + decapeptyl treatment, FSH and LH levels were suppressed, with partially restored growth plate architecture and improved TBV.
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2105336411
12AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, estradiol plus decapeptyl improved trabecular bone volume.
In plain wordsIn rats with removed ovaries, estradiol plus decapeptyl improved trabecular bone volume.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableTrabecular bone volume with combined treatment
Study
ratn: not reported in source
Ovariectomized Wistar-derived female rats
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In the E(2) + decapeptyl treatment, FSH and LH levels were suppressed, with partially restored growth plate architecture and improved TBV.
1 context sentence(design, population, supporting numbers)
Summary · context
Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2105336412

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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