The effects of kisspeptin-54 on blood pressure in humans and plasma kisspeptin concentrations in hypertensive diseases of pregnancy.

Nijher GM, Chaudhri OB, Ramachandran R, Murphy KG, Zac-Varghese SE, Fowler A, Chinthapalli K, Patterson M, Thompson EL, Williamson C, Kumar S, Ghatei MA, Bloom SR, Dhillo WS

British journal of clinical pharmacology1 Nov 2010Cited by 27 (Europe PMC)

PMID21039761PMCIDPMC2997307DOI10.1111/j.1365-2125.2010.03746.xPepBankPUB-21039761

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

2 results from studies that gave the peptide. 2 results from people.

01HumanNon-randomized trialSafety outcome
In healthy men and women, kisspeptin‑54 administration was not associated with significant changes in blood pressure.
In plain wordsIn healthy men and women, kisspeptin‑54 was not linked to changes in blood pressure.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeBlood pressure after kisspeptin-54
Study
n: not reported in source
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Administration of kisspeptin was not associated with significant changes in HR or BP in healthy men or women.
1 context sentence(design, population, supporting numbers)
Summary · context
However, data were also collected on BP and HR for 4h post administration of kisspeptin-54.
Report a problemFND-2103976101
02HumanNon-randomized trialSafety outcome
In healthy men and women, kisspeptin‑54 administration was not associated with significant changes in heart rate.
In plain wordsIn healthy men and women, kisspeptin‑54 was not linked to changes in heart rate.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeHeart rate after kisspeptin-54
Study
n: not reported in source
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Administration of kisspeptin was not associated with significant changes in HR or BP in healthy men or women.
1 context sentence(design, population, supporting numbers)
Summary · context
However, data were also collected on BP and HR for 4h post administration of kisspeptin-54.
Report a problemFND-2103976102

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

03HumanEndogenous levelObservational studyOther
In pregnant women, natural plasma kisspeptin-IR did not differ significantly between those with hypertensive diseases of pregnancy and normotensive controls.
In plain wordsIn pregnant women, the body's own kisspeptin levels did not differ between those with high blood pressure and those without.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changePlasma kisspeptin-IR in hypertensive diseases of pregnancy
Study
n = 105
Comparator
Normotensive pregnant controls
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
No significant differences in plasma kisspeptin-IR concentrations were observed between women with hypertensive diseases of pregnancy and normotensive pregnant controls
1 context sentence(design, population, supporting numbers)
Summary · context
Blood samples were taken from 105 women in the third trimester of pregnancy (27 women with hypertensive diseases of pregnancy and 78 controls).
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2103976105
04HumanEndogenous levelObservational studyOther
In healthy pregnant women, natural plasma kisspeptin concentration did not correlate significantly with blood pressure.
In plain wordsIn healthy pregnant women, the body's own kisspeptin levels were not linked to blood pressure.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeCorrelation of plasma kisspeptin with blood pressure in healthy pregnancy
Study
n = 78
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
There was no significant correlation between plasma kisspeptin concentration and BP in healthy pregnant women or in those with hypertensive diseases of pregnancy.
1 context sentence(design, population, supporting numbers)
Summary · context
Blood samples were taken from 105 women in the third trimester of pregnancy (27 women with hypertensive diseases of pregnancy and 78 controls).
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2103976103
05HumanEndogenous levelObservational studyOther
In women with hypertensive diseases of pregnancy, natural plasma kisspeptin concentration did not correlate significantly with blood pressure.
In plain wordsIn women with high blood pressure in pregnancy, the body's own kisspeptin levels were not linked to blood pressure.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeCorrelation of plasma kisspeptin with blood pressure in hypertensive pregnancy
Study
n = 27
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
There was no significant correlation between plasma kisspeptin concentration and BP in healthy pregnant women or in those with hypertensive diseases of pregnancy.
1 context sentence(design, population, supporting numbers)
Summary · context
Blood samples were taken from 105 women in the third trimester of pregnancy (27 women with hypertensive diseases of pregnancy and 78 controls).
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2103976104
06HumanEndogenous levelObservational studyOther
In pregnant women, natural plasma kisspeptin-IR in pregnancy-induced hypertension did not differ significantly from normotensive controls.
In plain wordsIn pregnant women, the body's own kisspeptin levels with pregnancy-induced high blood pressure did not differ from controls.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changePlasma kisspeptin-IR in pregnancy-induced hypertension
Study
n: not reported in source
Comparator
Normotensive pregnant controls
Outcome group
Blood pressure · Cardiovascular
Measurements
Plasma kisspeptin-IR
2696 pmol/l
pregnancy-induced hypertension
Plasma kisspeptin-IR
2878 pmol/l
controls
Source sentences
Summary
plasma kisspeptin concentrations ±SE: controls 2878 ± 157pmol l(-1) ; pregnancy-induced hypertension 2696 ± 299pmoll(-1) (95% CI vs. controls -514, 878pmoll(-1) ); pre-eclampsia 3519 ± 357 (95% CI vs. controls -1644, 362pmoll(-1) ).
1 context sentence(design, population, supporting numbers)
Summary · context
Blood samples were taken from 105 women in the third trimester of pregnancy (27 women with hypertensive diseases of pregnancy and 78 controls).
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2103976106
07HumanEndogenous levelObservational studyOther
In pregnant women, natural plasma kisspeptin-IR in pre-eclampsia did not differ significantly from normotensive controls.
In plain wordsIn pregnant women, the body's own kisspeptin levels with pre-eclampsia did not differ from controls.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changePlasma kisspeptin-IR in pre-eclampsia
Study
n: not reported in source
Comparator
Normotensive pregnant controls
Outcome group
Blood pressure · Cardiovascular
Measurements
Plasma kisspeptin-IR
3519 pmol/l
pre-eclampsia
Plasma kisspeptin-IR
2878 pmol/l
controls
Source sentences
Summary
plasma kisspeptin concentrations ±SE: controls 2878 ± 157pmol l(-1) ; pregnancy-induced hypertension 2696 ± 299pmoll(-1) (95% CI vs. controls -514, 878pmoll(-1) ); pre-eclampsia 3519 ± 357 (95% CI vs. controls -1644, 362pmoll(-1) ).
1 context sentence(design, population, supporting numbers)
Summary · context
Blood samples were taken from 105 women in the third trimester of pregnancy (27 women with hypertensive diseases of pregnancy and 78 controls).
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2103976107

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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