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Study · Ex vivo tissue · rat · 2011

8 results

The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.

Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH

Journal of applied physiology (Bethesda, Md. : 1985)28 Oct 2010Cited by 101 (Europe PMC)

PMID21030672 (opens in a new tab)DOI10.1152/japplphysiol.00945.2010 (opens in a new tab)PepBankPUB-21030672
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In tendon explants, BPC‑157 significantly accelerated the outgrowth of tendon fibroblasts.

    In plain wordsIn lab tests on tendon tissue, BPC‑157 sped up the growth of cells out of the tissue.

    Peptide
    BPC-157
    Outcome
    IncreaseOutgrowth of tendon fibroblasts from explants
    Study

    n: not reported in source

    tendon explants
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants.
    1 context sentence
    Summary · context
    The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined.
  2. 02LabIn vitro (cells)Mechanism

    In cultured tendon fibroblasts from rat Achilles tendon, BPC‑157 did not directly affect cell proliferation.

    In plain wordsIn cells, BPC‑157 did not directly change how fast tendon cells multiplied.

    Peptide
    BPC-157
    Outcome
    No significant changeTendon fibroblast proliferation (MTT assay)
    Study

    ratn: not reported in source

    tendon fibroblasts
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay.
  3. 03LabIn vitro (cells)Efficacy outcome

    In tendon fibroblasts, survival of BPC‑157-treated cells was significantly increased under H2O2 stress.

    In plain wordsIn cells, BPC‑157 increased the survival of tendon cells under stress.

    Peptide
    BPC-157
    Outcome
    IncreaseFibroblast survival under H2O2 stress
    Study

    ratn: not reported in source

    tendon fibroblasts
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the survival of BPC 157-treated cells was significantly increased under the H(2)O(2) stress.
  4. 04LabIn vitro (cells)Efficacy outcome

    In tendon fibroblasts, BPC‑157 markedly increased migration in a dose-dependent manner.

    In plain wordsIn cells, BPC‑157 increased the movement of tendon cells, more at higher doses.

    Peptide
    BPC-157
    Outcome
    IncreaseFibroblast migration (transwell assay)
    Study

    ratn: not reported in source

    tendon fibroblasts
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay.
  5. 05LabIn vitro (cells)Efficacy outcome

    In tendon fibroblasts, BPC‑157 dose dependently accelerated spreading on culture dishes.

    In plain wordsIn cells, BPC‑157 sped up the spreading of tendon cells, more at higher doses.

    Peptide
    BPC-157
    Outcome
    IncreaseFibroblast spreading on culture dishes
    Study

    ratn: not reported in source

    tendon fibroblasts
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes.
  6. 06LabIn vitro (cells)Mechanism

    In tendon fibroblasts, F-actin formation was induced by BPC‑157 treatment.

    In plain wordsIn cells, BPC‑157 increased formation of a cell skeleton protein.

    Peptide
    BPC-157
    Outcome
    IncreaseF-actin formation
    Study

    ratn: not reported in source

    tendon fibroblasts
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts.
  7. 07LabIn vitro (cells)Mechanism

    In tendon fibroblasts, BPC‑157 dose dependently increased the phosphorylation of FAK and paxillin.

    In plain wordsIn cells, BPC‑157 increased activation of two movement-related proteins, more at higher doses.

    Peptide
    BPC-157
    Outcome
    IncreaseFAK and paxillin phosphorylation
    Study

    ratn: not reported in source

    tendon fibroblasts
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered.
  8. 08LabIn vitro (cells)Mechanism

    In tendon fibroblasts, the total amounts of FAK and paxillin protein were unaltered by BPC‑157.

    In plain wordsIn cells, BPC‑157 did not change the total amount of two movement-related proteins.

    Peptide
    BPC-157
    Outcome
    No significant changeTotal FAK and paxillin protein
    Study

    ratn: not reported in source

    tendon fibroblasts
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while the total amounts of protein was unaltered.
    1 context sentence
    Summary · context
    The protein expression and activation of FAK and paxillin were determined by Western blot analysis

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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