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Study · Randomized controlled trial · 2010

5 results

Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones in women with hypothalamic amenorrhea.

Jayasena CN, Nijher GM, Abbara A, Murphy KG, Lim A, Patel D, Mehta A, Todd C, Donaldson M, Trew GH, Ghatei MA, Bloom SR, Dhillo WS

Clinical pharmacology and therapeutics27 Oct 2010Cited by 86 (Europe PMC)

PMID20980998 (opens in a new tab)DOI10.1038/clpt.2010.204 (opens in a new tab)PepBankPUB-20980998
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In women with hypothalamic amenorrhea, twice-daily kisspeptin‑54 injections gradually reduced the LH response.

    In plain wordsIn women with hypothalamic amenorrhea, twice-daily kisspeptin‑54 gradually weakened the body's LH response.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseLH responsiveness with twice-daily KP-54
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When KP-54 was administered twice daily, responsiveness to luteinizing hormone (LH) diminished gradually, whereas responsiveness to follicle-stimulating hormone (FSH) was nearly abolished by day 2.
    1 context sentence
    Summary · context
    We determined the time course of desensitization to twice-daily KP-54 injections, compared the effects of twice-daily and twice-weekly administration regimens of KP-54, and studied the effects of long-term twice-weekly administration of KP-54 on the release of reproductive hormones in women with HA.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women with hypothalamic amenorrhea, twice-daily kisspeptin‑54 injections nearly abolished the FSH response by day 2.

    In plain wordsIn women with hypothalamic amenorrhea, twice-daily kisspeptin‑54 almost removed the FSH response by day 2.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseFSH responsiveness with twice-daily KP-54
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When KP-54 was administered twice daily, responsiveness to luteinizing hormone (LH) diminished gradually, whereas responsiveness to follicle-stimulating hormone (FSH) was nearly abolished by day 2.
    1 context sentence
    Summary · context
    We determined the time course of desensitization to twice-daily KP-54 injections, compared the effects of twice-daily and twice-weekly administration regimens of KP-54, and studied the effects of long-term twice-weekly administration of KP-54 on the release of reproductive hormones in women with HA.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women with hypothalamic amenorrhea, twice-weekly kisspeptin‑54 caused only partial desensitization, while twice-daily dosing caused complete tolerance.

    In plain wordsIn women with hypothalamic amenorrhea, twice-weekly kisspeptin‑54 weakened the response only in part. Twice-daily dosing removed it fully.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseDesensitization with twice-weekly KP-54
    Study

    n: not reported in source

    Comparator
    Twice-daily KP-54
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Twice-weekly KP-54 administration resulted in only partial desensitization, in contrast to the complete tolerance achieved with twice-daily administration.
    1 context sentence
    Summary · context
    We determined the time course of desensitization to twice-daily KP-54 injections, compared the effects of twice-daily and twice-weekly administration regimens of KP-54, and studied the effects of long-term twice-weekly administration of KP-54 on the release of reproductive hormones in women with HA.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In women with hypothalamic amenorrhea, 8 weeks of twice-weekly kisspeptin‑54 injections raised reproductive hormone levels compared with saline.

    In plain wordsIn women with hypothalamic amenorrhea, twice-weekly kisspeptin‑54 for 8 weeks raised reproductive hormone levels more than saline.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseReproductive hormone levels after 8 weeks of twice-weekly KP-54
    Study

    n: not reported in source

    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    Women with HA who were treated with twice-weekly KP-54 injections had significantly elevated levels of reproductive hormones after 8 weeks as compared with treatment with saline.
    1 context sentence
    Summary · context
    We determined the time course of desensitization to twice-daily KP-54 injections, compared the effects of twice-daily and twice-weekly administration regimens of KP-54, and studied the effects of long-term twice-weekly administration of KP-54 on the release of reproductive hormones in women with HA.
  5. 05HumanRandomized controlled trialSafety outcome

    In women with hypothalamic amenorrhea, no adverse effects were observed with kisspeptin‑54.

    In plain wordsIn women with hypothalamic amenorrhea, researchers saw no side effects with kisspeptin‑54.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeAdverse effects
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No adverse effects were observed.
    1 context sentence
    Summary · context
    We determined the time course of desensitization to twice-daily KP-54 injections, compared the effects of twice-daily and twice-weekly administration regimens of KP-54, and studied the effects of long-term twice-weekly administration of KP-54 on the release of reproductive hormones in women with HA.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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